Use of a Target‐Mediated Drug Disposition Model to Predict the Human Pharmacokinetics and Target Occupancy of GC 1118, an Anti‐epidermal Growth Factor Receptor Antibody

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.12675 ◽

2016 ◽

Vol 120 (3) ◽

pp. 243-249 ◽

Author(s):

Wan‐Su Park ◽

Seunghoon Han ◽

Jongtae Lee ◽

Taegon Hong ◽

Jonghwa Won ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Drug Disposition ◽

Growth Factor Receptor ◽

Human Pharmacokinetics ◽

Receptor Antibody ◽

Target Mediated Drug Disposition ◽

Epidermal Growth ◽

Disposition Model

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Application of target-mediated drug disposition model to predict human pharmacokinetics and target occupancy of GC1118, an anti-epidermal growth factor receptor antibody

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2016.10.344 ◽

2017 ◽

Vol 32 (1) ◽

pp. S89

Author(s):

Wan-Su Park ◽

Seunghoon Han ◽

Jongtae Lee ◽

Taegon Hong ◽

Dong-Seok Yim

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Drug Disposition ◽

Growth Factor Receptor ◽

Human Pharmacokinetics ◽

Receptor Antibody ◽

Target Mediated Drug Disposition ◽

Epidermal Growth ◽

Disposition Model

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Panitumumab, a Monoclonal Anti–Epidermal Growth Factor Receptor Antibody in Colorectal Cancer: Another One or the One?: Table 1.

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-0065 ◽

2007 ◽

Vol 13 (16) ◽

pp. 4664-4666 ◽

Author(s):

Wells A. Messersmith ◽

Manuel Hidalgo

Keyword(s):

Colorectal Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Antibody ◽

Epidermal Growth ◽

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Association between serum ligands and the skin toxicity of anti‐epidermal growth factor receptor antibody in metastatic colorectal cancer

Cancer Science ◽

10.1111/cas.12642 ◽

2015 ◽

Vol 106 (5) ◽

pp. 604-610 ◽

Author(s):

Naoki Takahashi ◽

Yasuhide Yamada ◽

Koh Furuta ◽

Kengo Nagashima ◽

Akiko Kubo ◽

...

Keyword(s):

Colorectal Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Metastatic Colorectal Cancer ◽

Growth Factor Receptor ◽

Skin Toxicity ◽

Receptor Antibody ◽

Epidermal Growth

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Follicular Toxic Effects of Chimeric Anti-Epidermal Growth Factor Receptor Antibody Cetuximab Used to Treat Human Solid Tumors

Archives of Dermatology ◽

10.1001/archderm.138.1.129 ◽

2002 ◽

Vol 138 (1) ◽

pp. 129-131 ◽

Author(s):

A. Kimyai-Asadi

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Solid Tumors ◽

Growth Factor Receptor ◽

Toxic Effects ◽

Receptor Antibody ◽

Human Solid Tumors ◽

Epidermal Growth

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Oncogenic Activation of the RAS/RAF Signaling Pathway Impairs the Response of Metastatic Colorectal Cancers to Anti–Epidermal Growth Factor Receptor Antibody Therapies

Yearbook of Oncology ◽

10.1016/s1040-1741(08)79105-x ◽

2008 ◽

Vol 2008 ◽

pp. 323-324

Author(s):

M.S. Gordon

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Signaling Pathway ◽

Growth Factor Receptor ◽

Colorectal Cancers ◽

Receptor Antibody ◽

Epidermal Growth

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Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3182398e69 ◽

2012 ◽

Vol 7 (2) ◽

pp. 272-280 ◽

Author(s):

Tadaaki Yamada ◽

Shinji Takeuchi ◽

Kenji Kita ◽

Hideaki Bando ◽

Takahiro Nakamura ◽

...

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Hepatocyte Growth Factor ◽

Growth Factor Receptor ◽

Receptor Antibody ◽

Epidermal Growth ◽

Hepatocyte Growth

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Enhanced tumor retention of radioiodinated anti-epidermal growth factor receptor antibody using novel bifunctional iodination linker for radioimmunotherapy

Oncology Reports ◽

10.3892/or.2016.4706 ◽

2016 ◽

Vol 35 (6) ◽

pp. 3159-3168 ◽

Author(s):

EUN JUNG KIM ◽

BYOUNG SOO KIM ◽

DAN BEE CHOI ◽

SUNG-GIL CHI ◽

TAE HYUN CHOI

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Antibody ◽

Epidermal Growth ◽

Tumor Retention

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Inhibitory effect of anti-epidermal growth factor receptor antibody on a human gastric cancer

Cancer ◽

10.1002/(sici)1097-0142(19960415)77:8+<1639::aid-cncr9>3.0.co;2-8 ◽

1996 ◽

Vol 77 (S8) ◽

pp. 1639-1645

Author(s):

Tadashi Teramoto ◽

Masahiko Onda ◽

Akira Tokunaga ◽

Goro Asano

Keyword(s):

Gastric Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Inhibitory Effect ◽

Human Gastric Cancer ◽

Receptor Antibody ◽

Epidermal Growth

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Biomarkers for Predicting the Efficacy of Anti-Epidermal Growth Factor Receptor Antibody in the Treatment of Colorectal Cancer

Digestion ◽

10.1159/000356202 ◽

2014 ◽

Vol 89 (1) ◽

pp. 18-23 ◽

Author(s):

Yasuyuki Okada ◽

Hiroshi Miyamoto ◽

Takahiro Goji ◽

Tetsuji Takayama

Keyword(s):

Colorectal Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Antibody ◽

Epidermal Growth

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Immunohistochemical Investigations with a Monoclonal Anti-Epidermal Growth Factor Receptor Antibody in Supratentorial Tumors in Children

Advances in Neurosurgery - Intracranial Angiomas Neurosurgical Intensive Care Supratentorial Tumors in Children ◽

10.1007/978-3-642-76182-9_35 ◽

1991 ◽

pp. 180-183

Author(s):

J. Behnke ◽

H. Ludwig ◽

G. A. Luckenbach ◽

B. Rama ◽

E. Markakis

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Antibody ◽

Epidermal Growth ◽

Supratentorial Tumors

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