scholarly journals Is ECT a viable option to treat depression in older adults with bipolar disorder who are vulnerable to cognitive side effects?

2020 ◽  
Author(s):  
Machteld A. J. T. Blanken ◽  
Mardien L. Oudega ◽  
Sigfried N. T. M. Schouws ◽  
Jeroen S. Zanten ◽  
Jennifer R. Gatchel ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Side Effects ◽  
Viable Option ◽  
Cognitive Side Effects

scholarly journals Utilization of Medications With Cognitive Impairment Side Effects and the Implications for Older Adults’ Cognitive Function

2020 ◽  
Vol 32 (9) ◽  
pp. 1165-1177 ◽  
Author(s):  
Duy Do ◽  
Jason Schnittker
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Side Effects ◽  
Word Learning ◽  
Memory Loss ◽  
Digit Symbol ◽  
Digit Symbol Substitution ◽  
Symbol Substitution ◽  
Cognitive Side Effects

Objectives: Many medications have cognitive impairment, memory loss, amnesia, or dementia as side effects (“cognitive side effects” hereafter), but little is known about trends in the prevalence of these medications or their implications for population-level cognitive impairment. Method: We use data from the National Health and Nutrition Examination Survey (1999–2016) to describe trends in the use of medications with cognitive side effects among adults aged 60+ ( N = 16,937) and their implications for cognitive functioning (measured using word learning and recall, animal fluency, and digit symbol substitution assessments). Results: Between 1999 to 2000 and 2015 to 2016, the prevalence of older adults taking one, two, and at least three medications with cognitive side effects increased by 10.2%, 57.3%, and 298.7%, respectively. Compared to non-users, respondents who simultaneously used three or more medications with cognitive side effects scored 0.22 to 0.27 standard deviations lower in word learning and recall ( p = .02), digit symbol substitution ( p < .01), and the average standardized score of the three assessments ( p < .001). Limitation: Dosage of medications associated with cognitive side effects was not measured. Discussion: Concurrent use of medications with cognitive side effects among older adults has increased dramatically over the past two decades. The use of such medications is associated with cognitive impairment and may explain for disparities in cognitive function across subgroups. These findings highlight the need for cognitive screenings among patients who consume medications with cognitive side effects. They also highlight the synergic effects of polypharmacy and potential drug-drug interactions that result in cognitive deficits.

scholarly journals Clinical Characteristics of Bipolar Disorder Patients with Mood Stabilizer-Induced Cognitive Side Effects findings from the REAP-BD Survey in Korea

2020 ◽  
Vol 59 (3) ◽  
pp. 277
Author(s):  
Hihyun Shin ◽  
Jin Hee Choi ◽  
Hyungseok So ◽  
Hayun Choi ◽  
Yong Chon Park ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Clinical Characteristics ◽  
Mood Stabilizer ◽  
Cognitive Side Effects

Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice

1999 ◽  
Vol 14 ◽  
pp. 167-171 ◽  
Author(s):  
A Honig ◽  
B M G Arts ◽  
R W H M Ponds ◽  
W J Riedel
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Qualitative Analysis ◽  
Daily Practice ◽  
Cognitive Side Effects

scholarly journals Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Eric Cretaz ◽  
André R. Brunoni ◽  
Beny Lafer
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Mood Disorders ◽  
Bipolar Depression ◽  
Eligibility Criteria ◽  
Magnetic Seizure Therapy ◽  
Antidepressant Effects ◽  
Depressive Episodes ◽  
Cognitive Side Effects ◽  
Review Current

Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valuable tool in the treatment of mood disorders, such as major depressive disorder (MDD) and bipolar disorder. Our aim is to review current literature on MST.Methods. OVID and MEDLINE databases were used to systematically search for clinical studies on MST. The terms “magnetic seizure therapy,” “depression,” and “bipolar” were employed.Results. Out of 74 studies, 8 met eligibility criteria. There was considerable variability in the methods employed and samples sizes were small, limiting the generalization of the results. All studies focused on depressive episodes, but few included patients with bipolar disorder. The studies found reported significant antidepressant effects, with remission rates ranging from 30% to 40%. No significant cognitive side effects related to MST were found, with a better cognitive profile when compared to ECT. Conclusion. MST was effective in reducing depressive symptoms in mood disorders, with generally less side effects than ECT. No study focused on comparing MST to ECT on bipolar depression specifically.

Lithium induced cognitive side-effects in bipolar disorder

1999 ◽  
Vol 14 (3) ◽  
pp. 167-172 ◽  
Author(s):  
A. Honig ◽  
B. M.G. Arts ◽  
R. W.H.M. Ponds ◽  
W. J. Riedel
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Cognitive Side Effects

New Drug for Overactive Bladder Lacks Cognitive Side Effects

2005 ◽  
Vol 35 (5) ◽  
pp. 67
Author(s):  
BRUCE JANCIN
Keyword(s):  
Side Effects ◽  
Overactive Bladder ◽  
New Drug ◽  
Cognitive Side Effects

Treating bipolar disorder in older adults: Gaps in knowledge remain

2002 ◽  
Author(s):  
M. Sajatovic
Keyword(s):  
Older Adults ◽  
Bipolar Disorder

scholarly journals Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Melis Orhan ◽  
Nicole Korten ◽  
Ralph Kupka ◽  
Patricia van Oppen ◽  
Max Stek ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Internal Structure ◽  
Internal Consistency ◽  
Concurrent Validity ◽  
Cronbach’S Alpha ◽  
Occupational Functioning ◽  
Cronbach's Alpha ◽  
Short Test ◽  
Functioning Assessment

Abstract Background Many frequently used instruments fail to assess psychosocial functioning in patients with bipolar disorder. The Functioning Assessment Short Test (FAST) was developed in order to tackle this problem and to assess the main functioning problems experienced by patients with bipolar disorder. However, the original FAST is not fully applicable in older adults due to the domain of occupational functioning. The aim of our study was to validate an adapted version for Older adults (FAST-O) in a group of older adults with bipolar disorder (OABD). Methods 88 patients aged 50 years and over diagnosed with bipolar disorder were included. We adapted the items in the area of “work-related functioning” of the FAST into items assessing “societal functioning”. Several measurements were conducted in order to analyse the psychometric qualities of the FAST-O (confirmatory factor analysis for internal structure, Cronbach’s alpha for internal consistency, Spearman’s rho for concurrent validity, Mann–Whitney U test for discriminant validity). Results Mean age in the study sample was 65.3 (SD = 7.5) and 57.3% was female. The internal structure was most similar to the internal structure of the original FAST. The internal consistency was excellent (Cronbach’s alpha = .93). The concurrent validity when correlated with the Social and Occupational Functioning Assessment Scale was low, but significant. The FAST-O was also able to distinguish between euthymic and symptomatic OABD patients. Conclusions The FAST-O has strong psychometric qualities. Based on our results, we can conclude that the FAST-O is a short, efficient solution in order to replace global rating scales or extensive test batteries in order to assess daily functioning of older psychiatric patients in a valid and reliable manner.

The Cognitive Side Effects of Electroconvulsive Therapy.

1986 ◽  
Vol 462 (1 Electroconvul) ◽  
pp. 353-356 ◽  
Author(s):  
STEPHANIE PORTNOY
Keyword(s):  
Side Effects ◽  
Electroconvulsive Therapy ◽  
Cognitive Side Effects

Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality

2004 ◽  
Vol 483 (2-3) ◽  
pp. 271-279 ◽  
Author(s):  
Trond Myhrer ◽  
Siri Enger ◽  
Pål Aas
Keyword(s):  
Side Effects ◽  
Pharmacological Agents ◽  
Cognitive Side Effects
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