The heparin‐von Willebrand factor interaction and conventional tests of haemostasis – the challenges in predicting bleeding in cardiopulmonary bypass

2020 ◽  
Author(s):  
Amita Ranger ◽  
Mihaela Gaspar ◽  
Amira Elkhatteb ◽  
Tim Jackson ◽  
Steve Fox ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Von Willebrand Factor ◽  
Conventional Tests ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Interaction

scholarly journals Changes in von Willebrand factor during cardiac surgery: effect of desmopressin acetate

Blood ◽  
1988 ◽  
Vol 71 (6) ◽  
pp. 1648-1655 ◽  
Author(s):  
M Weinstein ◽  
JA Ware ◽  
J Troll ◽  
E Salzman
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Loss ◽  
Drug Treatment ◽  
Von Willebrand Factor ◽  
Drug Induced ◽  
Before And After ◽  
Artery Disease ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

Abstract Patients who receive desmopressin acetate (dDAVP) after cardiopulmonary bypass bleed less during operation and in the first 24 hours after operation than do patients who receive a placebo. To study the mechanism of improved hemostasis in bypass patients, we examined the relationship between von Willebrand factor (vWF) and blood loss in 70 cardiopulmonary bypass patients, one-half of whom received desmopressin intraoperatively. vWF concentration and multimeric composition were analyzed before and after bypass, after drug treatment, and 24 hours after operation. Before operation, patients with valvular disease had lower percentages of vWF high-mol-wt multimers (HMWMs) than did healthy subjects or patients with coronary artery disease, but subsequent blood loss, vWF activity, and bleeding times were not related to this finding. Irrespective of drug treatment, patients who had low preoperative vWF and who had a net loss of the protein during bypass bled more after bypass than did similar patients who had a net increase of vWF during bypass. HMWMs rose to above normal levels after bypass regardless of desmopressin infusion. Differences in the concentration of vWF between desmopressin and placebo patients after receipt of the drug, although small, were better correlated with reduced blood loss than were differences in HMWM distribution. We conclude that the beneficial effect of desmopressin on hemostasis following cardiopulmonary bypass cannot be attributed to a drug-induced change in HMWM distribution but may be related to an increase in overall vWF concentration.

Modeling ADAMTS13-von Willebrand Factor interaction: Implications for oxidative stress-related cardiovascular diseases and type 2A von Willebrand Disease

2012 ◽  
Vol 160 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Nicola Pozzi ◽  
Stefano Lancellotti ◽  
Raimondo De Cristofaro ◽  
Vincenzo De Filippis
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Interaction

Characterization of Murine Anti-Glycoprotein Ib Monoclonal Antibodies That Differentiate between Shear-Induced and Ristocetin/Botrocetin-Induced Glycoprotein Ib-von Willebrand Factor Interaction

2000 ◽  
Vol 30 (3) ◽  
pp. 139-148 ◽  
Author(s):  
N. Cauwenberghs ◽  
N. Ajzenberg ◽  
S. Vauterin ◽  
M.F. Hoylaerts ◽  
P.J. Declerck ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Von Willebrand Factor ◽  
Glycoprotein Ib ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Interaction

scholarly journals Abnormalities in von Willebrand factor and antithrombin III after cardiopulmonary bypass operations for congenital heart disease

1992 ◽  
Vol 103 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Sophronia O. Turner-Gomes ◽  
Maureen Andrew ◽  
John Coles ◽  
George A. Trusler ◽  
William G. Williams ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiopulmonary Bypass ◽  
Von Willebrand Factor ◽  
Congenital Heart ◽  
Antithrombin Iii ◽  
Von Willebrand ◽  
Willebrand Factor

Synthesis and modifications of a small library of 1,4-benzodiazepin-3-ones toward potential inhibitors of the collagen—von Willebrand Factor interaction

Tetrahedron ◽  
2009 ◽  
Vol 65 (23) ◽  
pp. 4521-4529 ◽  
Author(s):  
Tiny Deschrijver ◽  
Peter Verwilst ◽  
Katleen Broos ◽  
Hans Deckmyn ◽  
Wim Dehaen ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Potential Inhibitors ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Interaction

scholarly journals von Willebrand factor and urinary albumin excretion are possible indicators of endothelial dysfunction in cardiopulmonary bypass

1998 ◽  
Vol 13 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Geoffrey MK Tsang ◽  
Simon Allen ◽  
Domenico Pagano ◽  
Carl Wong ◽  
Timothy R Graham ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Endothelial Dysfunction ◽  
Von Willebrand Factor ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Albumin Excretion ◽  
Von Willebrand ◽  
Willebrand Factor
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