scholarly journals Gαssignalling of the CB1receptor and the influence of receptor number

2017 ◽  
Vol 174 (15) ◽  
pp. 2545-2562 ◽  
Author(s):  
David B Finlay ◽  
Erin E Cawston ◽  
Natasha L Grimsey ◽  
Morag R Hunter ◽  
Anisha Korde ◽  
...  
Keyword(s):  
Receptor Number

Decreased Dihydropyridine Receptor Number in Hypertensive Rat Vascular Muscle Cells

Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 731-734 ◽  
Author(s):  
Kent Hermsmeyer ◽  
Anita C. White ◽  
David J. Triggle
Keyword(s):  
Muscle Cells ◽  
Dihydropyridine Receptor ◽  
Vascular Muscle ◽  
Hypertensive Rat ◽  
Receptor Number ◽  
Vascular Muscle Cells

scholarly journals Thyroid hormone regulation of beta-adrenergic receptor number.

1977 ◽  
Vol 252 (8) ◽  
pp. 2787-2789 ◽  
Author(s):  
L T Williams ◽  
R J Lefkowitz ◽  
A M Watanabe ◽  
D R Hathaway ◽  
H R Besch
Keyword(s):  
Thyroid Hormone ◽  
Adrenergic Receptor ◽  
Hormone Regulation ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Receptor Number

scholarly journals Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.

1980 ◽  
Vol 255 (13) ◽  
pp. 6373-6381 ◽  
Author(s):  
B.E. Magun ◽  
L.M. Matrisian ◽  
G.T. Bowden
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tumor Promoter ◽  
Receptor Affinity ◽  
Epidermal Growth ◽  
Receptor Number

Triiodothyronine attenuates estradiol-induced increases in dopamine D-2 receptor number in rat anterior pituitary

1996 ◽  
Vol 712 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Jara Nedvídková ◽  
Karel Pacák ◽  
Jan Nedvidek ◽  
David S. Goldstein ◽  
Vratislav Schreiber
Keyword(s):  
Anterior Pituitary ◽  
Receptor Number

Growth of C6 glioma cells in serum-containing medium decreases ?-adrenergic receptor number

1981 ◽  
Vol 109 (2) ◽  
pp. 309-315 ◽  
Author(s):  
Mark D. Dibner ◽  
Paul A. Insel
Keyword(s):  
Adrenergic Receptor ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Receptor Number

scholarly journals Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

2000 ◽  
pp. 472-476 ◽  
Author(s):  
NA Huizenga ◽  
WW De Herder ◽  
JW Koper ◽  
P de Lange ◽  
D AJ v Lely ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
The Body ◽  
The Other ◽  
Down Regulation ◽  
Ligand Affinity ◽  
Other Hand ◽  
Receptor Number ◽  
Cortisol Levels

OBJECTIVE: Glucocorticoids (GCs) serve a variety of important functions throughout the body. The synthesis and secretion of GCs are under the strict influence of the hypothalamo-pituitary-adrenal axis. The mechanisms of action of GCs are mediated by the intracellular glucocorticoid receptor (GR). Over the years, many studies have been performed concerning the regulation of GR expression by GC concentrations. METHODS: In the present study, we determined the characteristics of the GR in peripheral mononuclear blood leukocytes (PBML) from thirteen patients with endogenous Cushing's syndrome and fifteen control subjects, using a whole cell dexamethasone binding assay. Furthermore, cortisol concentrations were determined in order to investigate a possible relationship between serum cortisol levels and receptor characteristics. RESULTS: There were no differences in mean receptor number between patients and controls. On the other hand, a significantly lower ligand affinity was identified in cells from patients with Cushing's syndrome compared with controls. A complete normalisation of the ligand affinity was observed after treatment in the only patient tested in this respect, whereas the receptor number was not affected. In patients, there was a statistically significant negative correlation between cortisol concentrations and ligand affinity, which was not found in controls. CONCLUSION: Receptor down-regulation does not occur in PBML from patients with endogenous Cushing's syndrome. On the other hand, there seems to be a diminished ligand affinity which possibly reflects receptor modification in response to exposure to the continuously high cortisol levels in patients with Cushing's syndrome. This assumption is substantiated by the fact that in one patient a normalisation of the ligand affinity after complete remission of the disease was seen.

PET Measurement of the Influence of Corticosteroids on Serotonin-1A Receptor Number

2002 ◽  
Vol 103 (s47) ◽  
pp. 64P-64P
Author(s):  
AJ Montgomery ◽  
CJ Bench ◽  
AH Young ◽  
A Hammers ◽  
Z Bhagwagar ◽  
...  
Keyword(s):  
Serotonin 1A Receptor ◽  
Receptor Number
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