scholarly journals Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients

2018 ◽  
Vol 109 (6) ◽  
pp. 2046-2055 ◽  
Author(s):  
Tomohiro Kadota ◽  
Ken Hatogai ◽  
Tomonori Yano ◽  
Takeo Fujita ◽  
Takashi Kojima ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Tumor Regression ◽  
Tumor Regression Grade ◽  
Metastatic Tumors ◽  
Regression Grade

scholarly journals Importance of Tumor Regression Grade in ypStage III Rectal Cancer Patients Treated with Neoadjuvant Chemoradiotherapy

2018 ◽  
Vol 102 (3) ◽  
pp. e3
Author(s):  
J.H. Chung ◽  
C. Song ◽  
S.B. Kang ◽  
D.W. Kim ◽  
J.H. Kim ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Tumor Regression ◽  
Neoadjuvant Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Regression Grade

Clinical outcomes in elderly rectal cancer patients treated with neoadjuvant chemoradiotherapy: impact of tumor regression grade

2020 ◽  
Author(s):  
Consuelo Rosa ◽  
Monica Di Tommaso ◽  
Luciana Caravatta ◽  
Maria Taraborrelli ◽  
Lucrezia Gasparini ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Tumor Regression ◽  
Neoadjuvant Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Regression Grade

scholarly journals Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2132
Author(s):  
Wan-Shan Li ◽  
Chih-I Chen ◽  
Hsin-Pao Chen ◽  
Kuang-Wen Liu ◽  
Chia-Jen Tsai ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Protein Transport ◽  
Tumor Regression ◽  
Preoperative Chemoradiation ◽  
Post Treatment ◽  
Tumor Regression Grade ◽  
Cancer Dataset ◽  
Free Survival ◽  
Regression Grade

Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (MLPH) gene as the most significant intracellular protein transport-related gene (GO:0006886) associated with a poor response to preoperative chemoradiation. An MLPH immunostain was performed on biopsy specimens from 172 rectal cancer patients receiving preoperative chemoradiation; samples were divided into high- and low-expression groups by H-scores. Subsequently, the correlations between MLPH expression and clinicopathologic features, tumor regression grade, disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS) were analyzed. MLPH expression was significantly associated with CEA level (p = 0.001), pre-treatment tumor status (p = 0.022), post-treatment tumor status (p < 0.001), post-treatment nodal status (p < 0.001), vascular invasion (p = 0.028), and tumor regression grade (p < 0.001). After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178–46.920; p = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762–17.931; p = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification.

Tumor regression grade and survival after neoadjuvant treatment in gastro-esophageal cancer: A meta-analysis of 17 published studies

2017 ◽  
Vol 43 (9) ◽  
pp. 1607-1616 ◽  
Author(s):  
G. Tomasello ◽  
F. Petrelli ◽  
M. Ghidini ◽  
E. Pezzica ◽  
R. Passalacqua ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tumor Regression ◽  
Meta Analysis ◽  
Neoadjuvant Treatment ◽  
Tumor Regression Grade ◽  
Regression Grade

scholarly journals Naples Prognostic Score Predicts Tumor Regression Grade in Resectable Gastric Cancer Treated with Preoperative Chemotherapy

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4676
Author(s):  
Eva Lieto ◽  
Annamaria Auricchio ◽  
Giuseppe Tirino ◽  
Luca Pompella ◽  
Iacopo Panarese ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Preoperative Chemotherapy ◽  
Multimodal Treatment ◽  
Tumor Regression ◽  
Prognostic Score ◽  
Tumor Regression Grade ◽  
Term Survival ◽  
Gastric Cancer Patients ◽  
Regression Grade

Despite recent progresses, locally advanced gastric cancer remains a daunting challenge to embrace. Perioperative chemotherapy and D2-gastrectomy depict multimodal treatment of gastric cancer in Europe, shows better results than curative surgery alone in terms of downstaging, micrometastases elimination, and improved long-term survival. Unfortunately, preoperative chemotherapy is useless in about 50% of cases of non-responder patients, in which no effect is registered. Tumor regression grade (TRG) is directly related to chemotherapy effectiveness, but its understanding is achieved only after surgical operation; accordingly, preoperative chemotherapy is given indiscriminately. Conversely, Naples Prognostic Score (NPS), related to patient immune-nutritional status and easily obtained before taking any therapeutic decision, appeared an independent prognostic variable of TRG. NPS was calculated in 59 consecutive surgically treated gastric cancer patients after neoadjuvant FLOT4-based chemotherapy. 42.2% of positive responses were observed: all normal NPS and half mild/moderate NPS showed significant responses to chemotherapy with TRG 1–3; while only 20% of the worst NPS showed some related benefits. Evaluation of NPS in gastric cancer patients undergoing multimodal treatment may be useful both in selecting patients who will benefit from preoperative chemotherapy and for changing immune-nutritional conditions in order to improve patient’s reaction against the tumor.

scholarly journals CA724 Predicts Tumor Regression Grade in Locally Advanced Gastric Cancer Patients with Neoadjuvant Chemotherapy

2021 ◽  
Vol 12 (21) ◽  
pp. 6465-6472
Author(s):  
Yilin Tong ◽  
Yanmei Zhu ◽  
Yan Zhao ◽  
Chengyao Jiang ◽  
Wentao Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Gastric Cancer ◽  
Cancer Patients ◽  
Tumor Regression ◽  
Locally Advanced ◽  
Tumor Regression Grade ◽  
Locally Advanced Gastric Cancer ◽  
Gastric Cancer Patients ◽  
Regression Grade

scholarly journals Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yilin Tong ◽  
Yanmei Zhu ◽  
Yan Zhao ◽  
Zexing Shan ◽  
Jianjun Zhang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Gastric Adenocarcinoma ◽  
Tumor Regression ◽  
Locally Advanced ◽  
Prognostic Significance ◽  
Tumor Regression Grade ◽  
Node Metastasis ◽  
Advanced Gastric Adenocarcinoma ◽  
Regression Grade

Background. Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adenocarcinoma patients who underwent NCT and curative resection. Methods. Pathological regression was reevaluated according to the Mandard TRG. Survival curves were obtained by the Kaplan–Meier method, and differences in overall survival (OS) and disease-free survival (DFS) were compared using the log-rank test. Univariate and multivariate analyses for survival were based on the Cox proportional hazards method. Results. In total, 290 patients were identified in our electronic database. In univariable analysis, TRG was associated with OS (HR=3.822, P≤0.001) and DFS (HR=3.374, P≤0.001). However, in multivariable analysis, TRG was not an independent factor for OS (P=0.231) or DFS (P=0.191). In the stratified analysis, TRG retrieved prognostic significance in patients with the metastasis of lymph node (HR=2.034, P=0.035 for OS; HR=2.220, P=0.016 for DFS), while not in patients with negative lymph node (P=0.296 for OS; P=0.172 for DFS). Conclusions. TRG was not an independent predictor for survival, but the system regained its predicting significance in patients with lymph node metastasis.

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