scholarly journals NOTCH 1 pathway activating mutations and clonal evolution in pediatric T‐cell acute lymphoblastic leukemia

2019 ◽  
Vol 110 (2) ◽  
pp. 784-794 ◽  
Author(s):  
Shunsuke Kimura ◽  
Masafumi Seki ◽  
Kenichi Yoshida ◽  
Yuichi Shiraishi ◽  
Masaharu Akiyama ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Clonal Evolution ◽  
Notch 1 ◽  
Activating Mutations ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals The oxidation of (−)-epigallocatechin-3-gallate inhibits T-cell acute lymphoblastic leukemia cell line HPB-ALL via the regulation of Notch1 expression

RSC Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1679-1684 ◽  
Author(s):  
Yu-Na Wang ◽  
Jing Wang ◽  
Hao-Nan Yang ◽  
Bang-Lei Zhang ◽  
Pan Zhang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Cell Line ◽  
Hematological Malignancy ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Activating Mutations ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia Cell Line

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and commonly associated with activating mutations in the Notch1 pathway.

scholarly journals Notch-1 Mutations Are Secondary Events in Some Patients with T-Cell Acute Lymphoblastic Leukemia

2007 ◽  
Vol 13 (23) ◽  
pp. 6964-6969 ◽  
Author(s):  
Marc R. Mansour ◽  
Veronique Duke ◽  
Letizia Foroni ◽  
Bella Patel ◽  
Christopher G. Allen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Notch 1 ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation

Cancer Cell ◽  
2014 ◽  
Vol 25 (3) ◽  
pp. 366-378 ◽  
Author(s):  
Jessica S. Blackburn ◽  
Sali Liu ◽  
Jayme L. Wilder ◽  
Kimberly P. Dobrinski ◽  
Riadh Lobbardi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Clonal Evolution ◽  
Cell Frequency ◽  
Pathway Activation ◽  
Mtorc1 Pathway ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

Leukemia ◽  
2006 ◽  
Vol 20 (3) ◽  
pp. 537-539 ◽  
Author(s):  
M R Mansour ◽  
D C Linch ◽  
L Foroni ◽  
A H Goldstone ◽  
R E Gale
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Adult Patients ◽  
Notch 1 ◽  
High Incidence ◽  
Cell Acute Lymphoblastic Leukemia
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