Allosteric mechanism of an oximino‐piperidino‐piperidine antagonist for the CCR5 chemokine receptor

Yangpeng Zhang; Hai‐Feng Chen

doi:10.1111/cbdd.13627

Allosteric mechanism of an oximino‐piperidino‐piperidine antagonist for the CCR5 chemokine receptor

Chemical Biology & Drug Design ◽

10.1111/cbdd.13627 ◽

2019 ◽

Vol 95 (1) ◽

pp. 113-123

Author(s):

Yangpeng Zhang ◽

Hai‐Feng Chen

Keyword(s):

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Allosteric Mechanism

Faculty Opinions recommendation of Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718106759.793484827 ◽

2013 ◽

Author(s):

Dimitrios Morikis

Keyword(s):

Chemokine Receptor ◽

Entry Inhibitor ◽

Ccr5 Chemokine Receptor ◽

Hiv Entry

Investigation of the Structural Requirement for Blocking the Human CCR5 Chemokine Receptor. An Insight from Quantitative Structure Activity Relationships Study

Letters in Drug Design & Discovery ◽

10.2174/157018009787582615 ◽

2009 ◽

Vol 6 (2) ◽

pp. 114-124 ◽

Cited By ~ 1

Author(s):

Nigus Dessalew

Keyword(s):

Chemokine Receptor ◽

Quantitative Structure ◽

Structural Requirement ◽

Ccr5 Chemokine Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Human Ccr5

The dual CCR2/CCR5 chemokine receptor antagonist Cenicriviroc reduces macrophage infiltration and disease severity in Duchenne muscular dystrophy (Dmdmdx-4Cv) mice

PLoS ONE ◽

10.1371/journal.pone.0194421 ◽

2018 ◽

Vol 13 (3) ◽

pp. e0194421 ◽

Cited By ~ 10

Author(s):

Feng Liang ◽

Christian Giordano ◽

Dong Shang ◽

Qian Li ◽

Basil J. Petrof

Keyword(s):

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Receptor Antagonist ◽

Disease Severity ◽

Chemokine Receptor ◽

Macrophage Infiltration ◽

Ccr5 Chemokine Receptor ◽

Chemokine Receptor Antagonist

Response: To force the expression of CCR4 and/or of CCR5 chemokine receptor in T cells for immunotherapy of Hodgkin lymphoma: that is the question

Blood ◽

10.1182/blood-2009-11-248302 ◽

2010 ◽

Vol 115 (3) ◽

pp. 748-748 ◽

Cited By ~ 1

Author(s):

Gianpietro Dotti ◽

Barbara Savoldo

Keyword(s):

T Cells ◽

Hodgkin Lymphoma ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor

Synthesis and SAR Studies of 4-(Heteroarylpiperidin-1-yl-methyl)-pyrrolidin-1-yl-acetic Acid Antagonists of the Human CCR5 Chemokine Receptor.

ChemInform ◽

10.1002/chin.200442159 ◽

2004 ◽

Vol 35 (42) ◽

Author(s):

K. Shankaran ◽

et al. et al.

Keyword(s):

Acetic Acid ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Sar Studies ◽

Human Ccr5

4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.07.074 ◽

2009 ◽

Vol 19 (17) ◽

pp. 4988-4992 ◽

Cited By ~ 8

Author(s):

Maosheng Duan ◽

Christopher Aquino ◽

George F. Dorsey ◽

Robert Ferris ◽

Wieslaw M. Kazmierski

Keyword(s):

Chemokine Receptor ◽

Receptor Antagonists ◽

Ccr5 Chemokine Receptor ◽

Anti Hiv ◽

Hiv 1

CCR5 chemokine receptor gene evolution in New World monkeys (Platyrrhini, Primates): implication on resistance to lentiviruses

Infection Genetics and Evolution ◽

10.1016/j.meegid.2004.07.009 ◽

2005 ◽

Vol 5 (3) ◽

pp. 271-280 ◽

Cited By ~ 11

Author(s):

Ieda P. Ribeiro ◽

Carlos G. Schrago ◽

Esmeralda A. Soares ◽

Alcides Pissinatti ◽

Hector N. Seuanez ◽

...

Keyword(s):

Chemokine Receptor ◽

New World ◽

Gene Evolution ◽

Receptor Gene ◽

New World Monkeys ◽

Ccr5 Chemokine Receptor ◽

Chemokine Receptor Gene

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

Science ◽

10.1126/science.1241475 ◽

2013 ◽

Vol 341 (6152) ◽

pp. 1387-1390 ◽

Cited By ~ 433

Author(s):

Q. Tan ◽

Y. Zhu ◽

J. Li ◽

Z. Chen ◽

G. W. Han ◽

...

Keyword(s):

Chemokine Receptor ◽

Entry Inhibitor ◽

Ccr5 Chemokine Receptor ◽

Hiv Entry

Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(04)00593-1 ◽

2004 ◽

Author(s):

K SHANKARAN

Keyword(s):

Acetic Acid ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Sar Studies ◽

Human Ccr5

Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: A potential mechanism for receptor dimerization

Genomics ◽

10.1016/j.ygeno.2007.04.009 ◽

2007 ◽

Vol 90 (2) ◽

pp. 213-224 ◽

Cited By ~ 23

Author(s):

Núria Vàzquez-Salat ◽

Naoya Yuhki ◽

Thomas Beck ◽

Stephen J. O'Brien ◽

William J. Murphy

Keyword(s):

Gene Conversion ◽

Chemokine Receptor ◽

Potential Mechanism ◽

Receptor Dimerization ◽

Ccr5 Chemokine Receptor