Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

2014 ◽  
Vol 44 (11) ◽  
pp. 1399-1408 ◽  
Author(s):  
S. G. Royce ◽  
C. X. F. Lim ◽  
K. P. Patel ◽  
B. Wang ◽  
C. S. Samuel ◽  
...  
Keyword(s):  
Airway Hyperresponsiveness ◽  
Airway Remodelling

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

2016 ◽  
Vol 130 (23) ◽  
pp. 2151-2165 ◽  
Author(s):  
Simon G. Royce ◽  
Anna M. Tominaga ◽  
Matthew Shen ◽  
Krupesh P. Patel ◽  
Brooke M. Huuskes ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Airway Hyperresponsiveness ◽  
Therapeutic Efficacy ◽  
Structural Changes ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Airway Remodelling ◽  
Human Amnion ◽  
Experimental Allergic ◽  
Amnion Epithelial Cells

We have identified combination cell-based therapies that effectively treat the airway inflammation and airway remodelling (structural changes) that contribute to airway obstruction and related airway hyperresponsiveness in murine chronic allergic airways.

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