Bone mineral density and trabecular bone score in patients with 21‐hydroxylase deficiency after glucocorticoid treatment

2020 ◽  
Author(s):  
Yinjie Gao ◽  
Ou Wang ◽  
Wenmin Guan ◽  
Xueyan Wu ◽  
Jiangfeng Mao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Glucocorticoid Treatment ◽  
21 Hydroxylase Deficiency

scholarly journals Impact of total cumulative glucocorticoid dose on bone mineral density in patients with 21-hydroxylase deficiency.

2008 ◽  
Vol 158 (6) ◽  
pp. 879-887 ◽  
Author(s):  
Zeina Chakhtoura ◽  
Anne Bachelot ◽  
Dinane Samara-Boustani ◽  
Jean-Charles Ruiz ◽  
Bruno Donadille ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Negative Impact ◽  
Negative Effects ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Glucocorticoid Treatment ◽  
Bone Demineralization ◽  
Salt Wasting ◽  
21 Hydroxylase Deficiency

ObjectiveIt remains controversial whether long-term glucocorticoids are charged of bone demineralization in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The aim of this study was to know whether cumulative glucocorticoid dose from the diagnosis in childhood to adulthood in patients with CAH had a negative impact on bone mineral density (BMD).DesignThis was a retrospective study.MethodsThirty-eight adult patients with classical and non-classical CAH were included. BMD was measured in the lumbar spine and femoral neck. Total cumulative glucocorticoid (TCG) and total average glucocorticoid (TAG) doses were calculated from pediatric and adult files.ResultsWe showed a difference between final and target heights (−0.82±0.92 s.d. for women and −1.31±0.84 s.d. for men; P<0.001). Seventeen patients (44.7%) had bone demineralization (35.7% of women and 70% of men). The 28 women had higher BMD than the 10 men for lumbar (−0.26±1.20 vs −1.25±1.33 s.d.; P=0.02) and femoral T-scores (0.21±1.30 s.d. versus −1.08±1.10 s.d.; P=0.007). In the salt-wasting group, women were almost significantly endowed with a better BMD than men (P=0.053). We found negative effects of TCG, TAG on lumbar (P<0.001, P=0.002) and femoral T-scores (P=0.006, P<0.001), predominantly during puberty. BMI was protective on BMD (P=0.006).ConclusionThe TCG is an important factor especially during puberty for a bone demineralization in patients with 21-hydroxylase deficiency. The glucocorticoid treatment should be adapted particularly at this life period and preventive measures should be discussed in order to limit this effect.

Abstract #225 Trabecular Bone Score is Lower in Patients on Permanent Hemodialysis Compared to Controls Matched for Bone Mineral Density

2019 ◽  
Vol 25 ◽  
pp. 77-78
Author(s):  
Roxana Dusceac ◽  
Dan Niculescu ◽  
Madalina Sorohan ◽  
Ramona Dobre ◽  
Catalina Poiana
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Mineral Density

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

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