scholarly journals Host membrane glycosphingolipids and lipid microdomains facilitateHistoplasma capsulatuminternalisation by macrophages

2018 ◽  
pp. e12976 ◽  
Author(s):  
Allan J. Guimarães ◽  
Mariana Duarte Cerqueira ◽  
Daniel Zamith‐Miranda ◽  
Pablo H. Lopez ◽  
Marcio L. Rodrigues ◽  
...  
Keyword(s):  
Lipid Microdomains ◽  
Host Membrane

scholarly journals SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1434
Author(s):  
Claudio Fenizia ◽  
Silvia Galbiati ◽  
Claudia Vanetti ◽  
Riccardo Vago ◽  
Mario Clerici ◽  
...  
Keyword(s):  
Underlying Mechanism ◽  
Membrane Receptors ◽  
Host Cells ◽  
Viral Agent ◽  
Blocking Antibody ◽  
Angiotensin Converting Enzyme 2 ◽  
Host Membrane ◽  
B Virus ◽  
Immunodeficiency Virus

In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses Spike proteins are responsible for their ability to interact with host membrane receptors and different proteins have been identified as SARS-CoV-2 interactors, among which Angiotensin-converting enzyme 2 (ACE2), and Basigin2/EMMPRIN/CD147 (CD147). CD147 plays an important role in human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, Kaposi’s sarcoma-associated herpesvirus, and severe acute respiratory syndrome coronavirus infections. In particular, SARS-CoV recognizes the CD147 receptor expressed on the surface of host cells by its nucleocapsid protein binding to cyclophilin A (CyPA), a ligand for CD147. However, the involvement of CD147 in SARS-CoV-2 infection is still debated. Interference with both the function (blocking antibody) and the expression (knock down) of CD147 showed that this receptor partakes in SARS-CoV-2 infection and provided additional clues on the underlying mechanism: CD147 binding to CyPA does not play a role; CD147 regulates ACE2 levels and both receptors are affected by virus infection. Altogether, these findings suggest that CD147 is involved in SARS-CoV-2 tropism and represents a possible therapeutic target to challenge COVID-19.

scholarly journals The cypsela (achene) of Echinacea purpurea as a diffusion unit of a community of microorganisms

2021 ◽  
Vol 105 (7) ◽  
pp. 2951-2965
Author(s):  
Massimiliano Cardinale ◽  
Marian Viola ◽  
Elisangela Miceli ◽  
Teresa Faddetta ◽  
Anna Maria Puglia ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Active Role ◽  
Echinacea Purpurea ◽  
Endophytic Microorganisms ◽  
Host Membrane ◽  
Key Points ◽  
Endophytic Bacterial Community ◽  
Pharmaceutical Properties ◽  
Stimulation Of

AbstractEchinacea purpurea is a plant cultivated worldwide for its pharmaceutical properties, mainly related to the stimulation of the immune system in the treatment of respiratory infections. The cypselas (fruits) of E. purpurea were examined in order to investigate the presence, localization and potential function(s) of endophytic microorganisms. Electron and confocal microscopy observations showed that three different components of microorganisms were associated to cypselas of E. purpurea: (i) one endocellular bacterial component in the cotyledons, enclosed within the host membrane; (ii) another more generic bacterial component adhering to the external side of the perianth; and (iii) a fungal component inside the porous layer of the perianth, the woody and porous modified residual of the flower, in the form of numerous hyphae able to cross the wall between adjacent cells. Isolated bacteria were affiliated to the genera Paenibacillus, Pantoea, and Sanguibacter. Plate tests showed a general resistance to six different antibiotics and also to an antimicrobial-producing Rheinheimera sp. test strain. Finally, microbiome-deprived E. purpurea seeds showed a reduced ability to germinate, suggesting an active role of the microbiome in the plant vitality. Our results suggest that the endophytic bacterial community of E. purpurea, previously found in roots and stem/leaves, might be already carried at the seed stage, hosted by the cotyledons. A further microbial fungal component is transported together with the seed in the perianth of the cypsela, whose remarkable structure may be considered as an adaptation for fungal transportation, and could influence the capability of the seed to germinate in the soil.Key Points• The fruit of Echinacea purpurea contains fungi not causing any damage to the plant.• The seed cotyledons contain endocellular bacteria.• Seed/fruit deprived of the microbiome showed a reduced ability to germinate.

Lipid Rafts and HIV Pathogenesis: Host Membrane Cholesterol Is Required for Infection by HIV Type 1

2001 ◽  
Vol 17 (11) ◽  
pp. 1009-1019 ◽  
Author(s):  
Zhaohao Liao ◽  
Lisa M. Cimakasky ◽  
Richard Hampton ◽  
Dzung H. Nguyen ◽  
James E.K. Hildreth
Keyword(s):  
Lipid Rafts ◽  
Membrane Cholesterol ◽  
Hiv Pathogenesis ◽  
Host Membrane ◽  
Hiv Type 1

Proteomic Analysis of Lipid Microdomains from Lipopolysaccharide-Activated Human Endothelial Cells

2005 ◽  
Vol 4 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Aly Karsan ◽  
Josip Blonder ◽  
Jennifer Law ◽  
Elisa Yaquian ◽  
David A. Lucas ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Proteomic Analysis ◽  
Human Endothelial Cells ◽  
Lipid Microdomains

Lipid Microdomains in Synapse Formation

2016 ◽  
Vol 7 (6) ◽  
pp. 833-841 ◽  
Author(s):  
C. Madwar ◽  
G. Gopalakrishnan ◽  
R. Bruce Lennox
Keyword(s):  
Synapse Formation ◽  
Lipid Microdomains

Hypoxia-induced modifications in plasma membranes and lipid microdomains in A549 cells and primary human alveolar cells

2008 ◽  
Vol 105 (2) ◽  
pp. 503-513 ◽  
Author(s):  
Laura Botto ◽  
Egidio Beretta ◽  
Alessandra Bulbarelli ◽  
Ilaria Rivolta ◽  
Barbara Lettiero ◽  
...  
Keyword(s):  
Plasma Membranes ◽  
A549 Cells ◽  
Alveolar Cells ◽  
Lipid Microdomains

scholarly journals Partitioning of the Serotonin Transporter into Lipid Microdomains Modulates Transport of Serotonin

2004 ◽  
Vol 279 (37) ◽  
pp. 38770-38778 ◽  
Author(s):  
Francesca Magnani ◽  
Christopher G. Tate ◽  
Samantha Wynne ◽  
Clive Williams ◽  
Jana Haase
Keyword(s):  
Serotonin Transporter ◽  
Lipid Microdomains

scholarly journals Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains

Cell Reports ◽  
2013 ◽  
Vol 4 (6) ◽  
pp. 1213-1223 ◽  
Author(s):  
Hongxia Zhao ◽  
Alphée Michelot ◽  
Essi V. Koskela ◽  
Vadym Tkach ◽  
Dimitrios Stamou ◽  
...  
Keyword(s):  
Lipid Microdomains ◽  
Bar Domains
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