Post‐reflux swallow‐induced peristaltic wave is impaired in laryngopharyngeal and gastro‐oesophageal reflux disease

2021 ◽  
Author(s):  
Jin‐soo Park ◽  
Hans Van der Wall ◽  
Gregory L Falk
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Peristaltic Wave ◽  
Oesophageal Reflux Disease

711 POST-REFLUX SWALLOW-INDUCED PERISTALTIC WAVE IS IMPAIRED IN LARYNGOPHARYNGEAL AND GASTRO-OESOPHAGEAL REFLUX DISEASE

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Jin-soo Park ◽  
Hans Van der Wall ◽  
Gregory Falk
Keyword(s):  
Roc Curve ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Reflux Episode ◽  
Oesophageal Reflux ◽  
Peristaltic Wave ◽  
Oesophageal Reflux Disease ◽  
Predominant Symptom ◽  
Symptom Profile ◽  
Gastric Contents

Abstract   Laryngopharyngeal reflux (LPR) and gastro-oesophageal reflux disease (GORD) result from the reflux of gastric contents. The post-reflux swallow-induced peristaltic wave (PSPW) induces chemical clearance following reflux events. PSPW index is a novel parameter that has been validated in GORD, but not in LPR. This study aimed to assess the efficacy of chemical clearance by assessing PSPW indices in patients with LPR and GORD. Methods Reviewers blindly analysed off-therapy impedance-pH tracings from 187 patients divided into LPR (n = 105) or GORD (n = 82) by predominant symptom profile. Conventional impedance-pH measures and PSPW indices were analysed for the two groups. Results Mean PSPW index in the LPR group was higher than in the GORD group (39.7% (±17.7%) vs. 20.6% (±13.4%); p < 0.001). Abnormally low PSPW index (<61%) was seen in 85 (81%) of the LPR group, and 80 (97.6%) of the GORD group (p < 0.001). Area under the ROC curve for PSPW index to diagnose LPR was 0.828 (95% CI: 0.767–0.889; p < 0.001). The LPR group had a lower AET (1.5% vs. 8.1%; p < 0.001) and fewer distal reflux episodes (46.5 (±24.5) vs. 64.4 (±39); p < 0.001). Conclusion PSPW was impaired in patients with LPR as well as oesophageal GORD, indicating an abnormality of chemical clearance following a reflux episode in both groups. PSPW index was more severely impaired in gastro-oesophageal reflux disease (GORD). The present study shows PSPW index is useful in aiding in the diagnosis of both LPR and GORD.

Oesophageal Adenocarcinoma after Surgery and Medication Against Gastro-Oesophageal Reflux Disease in a Nordic Cohort Study

2019 ◽  
Author(s):  
John Maret-Ouda ◽  
Giola Santoni ◽  
Karl Wahlin ◽  
Miia Artama ◽  
Nele Brusselaers ◽  
...  
Keyword(s):  
Cohort Study ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Oesophageal Reflux Disease

Gastro-oesophageal reflux disease

The Lancet ◽  
2006 ◽  
Vol 367 (9528) ◽  
pp. 2086-2100 ◽  
Author(s):  
Paul Moayyedi ◽  
Nicholas J Talley
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

scholarly journals The association between gastro-oesophageal reflux disease and subsequent rheumatoid arthritis occurrence: a nested case–control study from Taiwan

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e016667 ◽  
Author(s):  
Herng-Ching Lin ◽  
Sudha Xirasagar ◽  
Cha-Ze Lee ◽  
Chung-Chien Huang ◽  
Chao-Hung Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Diagnosis ◽  
Reflux Disease ◽  
Treatment Guidelines ◽  
Population Based ◽  
Oesophageal Reflux ◽  
Study Patient ◽  
Oesophageal Reflux Disease ◽  
Increased Risk

ObjectiveGastro-oesophageal reflux disease (GORD) is a common comorbidity among patients with rheumatoid arthritis (RA). While GORD has been attributed to the antirheumatic medications, no studies of human cohorts have investigated a link between GORD and RA. This study investigates whether GORD is associated with a subsequent RA diagnosis over a 5-year follow-up using a population-based dataset.SettingTaiwanParticipantsWe used data from the Taiwan Longitudinal Health Insurance Database. The study group consisted of 13 645 patients with an ambulatory claim showing a GORD diagnosis. We used propensity score matching to select 13 645 comparison patients (one per study patient with GORD).InterventionWe tracked each patient’s claims over a 5-year period to identify those who subsequently received a diagnosis of RA. Cox proportional hazard (PH) regression modelling was used for analysis.ResultsOver 5-year follow-up, RA incidence rate per 1000 person-years was 2.81 among patients with GORD and 0.84 among the comparison group. Cox PH modelling showed that GORD was independently associated with a 2.84-fold increased risk of RA (95% CI 2.09 to 3.85) over 5-year follow-up, after adjusting for the number of ambulatory care visits within the year following the index date (to mitigate surveillance bias).ConclusionsWe observed that GORD might associate with subsequent RA occurrence. Because current treatment guidelines for RA emphasise early diagnosis and prompt treatment, the observed association between GORD and RA may help acquaint clinicians to patients with GORD with higher RA risk and facilitate early diagnosis and treatment.

scholarly journals Sub-optimal proton pump inhibitor dosing is prevalent in patients with poorly controlled gastro-oesophageal reflux disease

2006 ◽  
Vol 23 (10) ◽  
pp. 1473-1477 ◽  
Author(s):  
N. T. GUNARATNAM ◽  
T. P. JESSUP ◽  
J. INADOMI ◽  
D. P. LASCEWSKI
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

Burden of Gastro-Oesophageal Reflux Disease in Patients with Persistent and Intense Symptoms Despite Proton Pump Inhibitor Therapy

2011 ◽  
Vol 31 (10) ◽  
pp. 703-715 ◽  
Author(s):  
Samira Toghanian ◽  
David A. Johnson ◽  
Nils-Olov Stålhammar ◽  
Frank Zerbib
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

scholarly journals Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease.

Gut ◽  
1992 ◽  
Vol 33 (1) ◽  
pp. 118-124 ◽  
Author(s):  
N J Bell ◽  
R H Hunt
Keyword(s):  
Gastric Acid ◽  
Reflux Disease ◽  
Acid Suppression ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease ◽  
Gastric Acid Suppression

Gastro-oesophageal reflux disease

The Lancet ◽  
2000 ◽  
Vol 356 (9223) ◽  
pp. 72-73 ◽  
Author(s):  
HG Gooszen
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease
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