Oesophageal Adenocarcinoma after Surgery and Medication Against Gastro-Oesophageal Reflux Disease in a Nordic Cohort Study

2019 ◽  
Author(s):  
John Maret-Ouda ◽  
Giola Santoni ◽  
Karl Wahlin ◽  
Miia Artama ◽  
Nele Brusselaers ◽  
...  
Keyword(s):  
Cohort Study ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Oesophageal Reflux Disease

scholarly journals Mortality in gastro-oesophageal reflux disease in a population-based nationwide cohort study of Swedish twins

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e037456
Author(s):  
Eivind Ness-Jensen ◽  
Giola Santoni ◽  
Eivind Gottlieb-Vedi ◽  
Anna Lindam ◽  
Nancy Pedersen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Reflux Disease ◽  
Population Based ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Secondary Outcome ◽  
Oesophageal Reflux Disease ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cancer Specific Mortality

ObjectivesThe public health disorder gastro-oesophageal reflux disease (GORD) is linked with several comorbidities, including oesophageal adenocarcinoma (OAC), but whether life expectancy is reduced by GORD is uncertain. This study assessed all-cause and cancer-specific mortality in GORD after controlling for confounding by heredity and other factors.DesignPopulation-based cohort study from 1998 to 2015.SettingSwedish nationwide study.ParticipantsTwins (n=40 961) born in 1958 or earlier in Sweden.ExposureGORD symptoms reported in structured computer-assisted telephone interviews.OutcomesThe primary outcome was all-cause mortality and the secondary outcome was cancer-specific mortality among twins with GORD and twins without GORD. HRs and 95% CIs were analysed using parametric survival models, both in individual twin analyses and co-twin pair analyses, with adjustment for body mass index, smoking, education and comorbidity.ResultsAmong 40 961 individual twins, 5812 (14.2%) had GORD at baseline and 8062 (19.7%) died during follow-up of up to 16 years. The risks of all-cause mortality (HR=1.00, 95% CI: 0.94–1.07) and cancer-specific mortality (HR=0.99, 95% CI: 0.89–1.10) were not increased in individual twins with GORD compared with individual twins without GORD. Similarly, there were no differences in mortality outcomes in within-pair analyses. The OAC-specific mortality rate was 0.45 (95% CI: 0.32–0.66) per 1000 person-years in individual twins with GORD and 0.22 (95% CI: 0.18–0.27) per 1000 person-years without GORD, rendering an adjusted HR of 2.01 (95% CI: 1.35–2.98).ConclusionsGORD did not increase all-cause or cancer-specific mortality when taking heredity and other confounders into account. The increased relative risk of mortality in OAC was low in absolute numbers.

scholarly journals Opposing time trends of peptic ulcer and reflux disease

Gut ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 327-333 ◽  
Author(s):  
H B El-Serag ◽  
A Sonnenberg
Keyword(s):  
Peptic Ulcer ◽  
Reflux Disease ◽  
Time Trends ◽  
The United States ◽  
Vital Statistics ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Similar Time ◽  
Death Rates ◽  
Oesophageal Reflux Disease

Background—Gastritis associated hypochlorhydria may be protective against gastro-oesophageal reflux disease. It was hypothesised that the historic decline inHelicobacter pylori infection resulted in a decline in peptic ulcer and a concomitant rise in reflux disease.Aims—To study the time trends of peptic ulcer and reflux disease.Methods—Hospitalisation rates were analysed using the computerised database of the US Department of Veterans Affairs from 1970 until 1995. Death rates were calculated from the Vital Statistics of the United States.Results—From 1970 to 1995, hospitalisation rates for gastric and duodenal ulcer, as well as gastric cancer fell, while the hospitalisation rates for gastro-oesophageal reflux disease and those for oesophageal adenocarcinoma rose significantly. Similar time trends were observed with respect to the death rates. There were notable ethnic differences. White subjects incurred higher rates of reflux disease and oesophageal adenocarcinoma and lower rates of gastric ulcer or cancer compared with non-whites.Conclusions—The ethnic variations and the opposing time trends of gastroduodenal versus oesophageal disease are consistent with the hypothesis that the declining infection rates of H pylori in the general population have led to a rise in the occurrence of gastro-oesophageal reflux disease and associated oesophageal adenocarcinoma.

scholarly journals Laparoscopic repeat surgery for gastro-oesophageal reflux disease: Results of the analyses of a cohort study of 117 patients from a multicenter experience

2020 ◽  
Vol 76 ◽  
pp. 121-127 ◽  
Author(s):  
Fabrizio Panaro ◽  
Piera Leon ◽  
Thierry Perniceni ◽  
Giorgio Bianchi ◽  
Francois-Regis Souche ◽  
...  
Keyword(s):  
Cohort Study ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Repeat Surgery ◽  
Oesophageal Reflux Disease

scholarly journals Associations between gastro-oesophageal reflux disease and a range of diseases: an umbrella review of systematic reviews and meta-analyses

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e038450
Author(s):  
JinJing Tan ◽  
Liqun Li ◽  
Xiaoyan Huang ◽  
Chengning Yang ◽  
Xue Liang ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Reflux Disease ◽  
Methodological Quality ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Measurement Tool ◽  
Copd Exacerbation ◽  
Oesophageal Reflux Disease ◽  
Increased Risk ◽  
Meta Analyses

ObjectiveNumerous meta-analyses have revealed the association between gastro-oesophageal reflux disease (GORD) and a range of diseases; however, the certainty of the evidence remains unclear. This study aimed to summarise and assess the certainty of evidence derived from meta-analyses.MethodsEmbase, PubMed, Web of Science, Cochrane Databases of Systematic Reviews, CNKI and Wangfang databases from their inception to 22 February 2020 were queried for systematic reviews and meta-analyses on the association between GORD and various diseases. The methodological quality of the included studies was assessed using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), and evidence certainty was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Statistical analysis was conducted using Stata V.15.ResultsTen publications with associations between GORD and different types of diseases were included. There was high heterogeneity (I2 >75%) among seven independent meta-analyses. Evidence for publication bias in two independent meta-analyses was also observed. According to the AMSTAR 2 approach, the methodological quality was high for 20% of meta-analyses, moderate for 10%, low for 40% and critically low for 30%. Based on GRADE approach, the certainty of evidence was high for the association between GORD and higher risk of chronic obstructive pulmonary disease (COPD) exacerbation (OR 5.37; 95% CI 2.71 to 10.64) and higher prevalence of oesophageal adenocarcinoma (OR 4.57; 95% CI 3.89 to 5.36), and it was moderate for the association between GORD and higher chronic rhinosinusitis prevalence (OR 2.16; 95% CI 1.37 to 3.48).ConclusionThe association between GORD and a range of diseases was extensively studied, and our findings revealed a high certainty of evidence of the association between GORD and an increased risk of COPD exacerbation as well as increased prevalence of oesophageal adenocarcinoma. Further investigations using systematic reviews and meta-analyses of high methodological quality that include prospective large cohort studies and adjusted confounders are warranted.PROSPERO registration numberCRD42019122264.

Gastro-oesophageal reflux disease

The Lancet ◽  
2006 ◽  
Vol 367 (9528) ◽  
pp. 2086-2100 ◽  
Author(s):  
Paul Moayyedi ◽  
Nicholas J Talley
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease
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