Donation after circulatory death is associated with increased fibrosis on 1‐year post‐transplant kidney allograft surveillance biopsy

2021 ◽  
Author(s):  
Dirk J. Windt ◽  
Rajil Mehta ◽  
Dana R. Jorgensen ◽  
Sundaram Hariharan ◽  
Parmjeet S. Randhawa ◽  
...  
Keyword(s):  
Donation After Circulatory Death ◽  
Kidney Allograft ◽  
Post Transplant ◽  
Transplant Kidney ◽  
Circulatory Death

86-P: The role of soluble CD30 testing as marker of post-transplant kidney allograft dysfunction

2009 ◽  
Vol 70 ◽  
pp. S55
Author(s):  
Julio C. Delgado ◽  
Igor Y. Pavlov ◽  
Fuad S. Shihab
Keyword(s):  
Kidney Allograft ◽  
Post Transplant ◽  
Allograft Dysfunction ◽  
Soluble Cd30 ◽  
Transplant Kidney

Risk Factors for Post-Transplant Death in Donation after Circulatory Death Liver Transplantation

2017 ◽  
Vol 31 (5) ◽  
pp. 393-401
Author(s):  
Song Liu ◽  
Ji Miao ◽  
Xiaolei Shi ◽  
Yafu Wu ◽  
Chunping Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Donation After Circulatory Death ◽  
Post Transplant ◽  
Circulatory Death

Donor acute kidney injury and its effect on 1‐year post‐transplant kidney allograft fibrosis

2020 ◽  
Vol 34 (2) ◽  
Author(s):  
Dirk J. Windt ◽  
Rajil Mehta ◽  
Dana R. Jorgensen ◽  
Patrick Bou‐Samra ◽  
Sundaram Hariharan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Kidney Allograft ◽  
Post Transplant ◽  
Transplant Kidney

scholarly journals Pre-arrest doxycycline protects donation after circulatory death kidneys

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael Moser ◽  
Sarah Schmid ◽  
Katherine Sawicka ◽  
Tamalina Banerjee ◽  
Erick McNair ◽  
...  
Keyword(s):  
Left Kidney ◽  
Kidney Injury ◽  
Donation After Circulatory Death ◽  
Cold Preservation ◽  
Treatment Groups ◽  
Mmp Inhibitor ◽  
Transplant Kidney ◽  
The Right ◽  
Circulatory Death

AbstractKidney injury during donation after circulatory determination of death (DCDD) includes warm ischemic (WI) injury from around the time of asystole, and cold ischemic (CI) injury during cold preservation. We have previously shown that Matrix Metalloproteinases (MMPs) are involved in CI injury and that Doxycycline (Doxy), an antibiotic and known MMP inhibitor, protects the transplant kidney during CI. The purpose of our study was to determine if Doxy given before asystole can also prevent injury during WI. A rat model of DCDD was used, including Control, Preemptive Doxy (45 mg/kg iv), and Preemptive and Perfusion (100 microM) Doxy groups. Thirty minutes after asystole, both kidneys were removed. The left kidney was perfused at 4 °C for 22 h, whereas the right was used to establish the degree of warm ischemic injury prior to cold preservation. MMP-2 in the perfusate was significantly reduced in both treatment groups [Control 43.7 ± 7.2 arbitrary units, versus Preemptive Doxy group 23.2 ± 5.5 (p = 0.03), and ‘Preemptive and Perfusion’ group 18.0 ± 5.6 (p = 0.02)]. Reductions in NGAL, LDH, and MMP-9 were also seen. Electron microscopy showed a marked reduction in mitochondrial injury scores in the treatment groups. Pre-arrest Doxy was associated with a reduction in injury markers and morphologic changes. Doxy may be a simple and safe means of protecting transplant kidneys from both WI and CI.

Post-Transplant Assessment of Donation after Circulatory Death (DCD) Cardic Allografts with MRI - An Update

2018 ◽  
Vol 37 (4) ◽  
pp. S15
Author(s):  
E. Pavlushkov ◽  
A. Page ◽  
S. Messer ◽  
A. Kydd ◽  
Y. Abu-Omar ◽  
...  
Keyword(s):  
Donation After Circulatory Death ◽  
Post Transplant ◽  
Circulatory Death

‘Spontaneous’ Subcapsular Hyperdensity of a Post-Transplant Kidney Allograft

Nephrology ◽  
2014 ◽  
Vol 19 (12) ◽  
pp. 815-815
Author(s):  
Dominique Guerrot ◽  
Ludivine Lebourg ◽  
Lynda Cheddani ◽  
Nicolas Noel ◽  
Jean-Pierre Louvel ◽  
...  
Keyword(s):  
Kidney Allograft ◽  
Post Transplant ◽  
Transplant Kidney

Uncontrolled donation after circulatory death and liver transplantation: evidence and unresolved issues

2020 ◽  
Vol 86 (2) ◽  
Author(s):  
Chiara Lazzeri ◽  
Manuela Bonizzoli ◽  
Fabio Marra ◽  
Paolo Muiesan ◽  
Davide Ghinolfi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Donation after circulatory death: possible strategies for in-situ organ preservation

2020 ◽  
Vol 86 (9) ◽  
Author(s):  
Marinella Zanierato ◽  
Daniele Dondossola ◽  
Alessandro Palleschi ◽  
Alberto Zanella
Keyword(s):  
Organ Preservation ◽  
Donation After Circulatory Death ◽  
Circulatory Death
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