Gene therapy for diabetic peripheral neuropathy: A randomized, placebo‐controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor

Clinical and Translational Science ◽

10.1111/cts.12977 ◽

2021 ◽

Author(s):

John A. Kessler ◽

Aziz Shaibani ◽

Christine N. Sang ◽

Mark Christiansen ◽

David Kudrow ◽

...

Keyword(s):

Gene Therapy ◽

Peripheral Neuropathy ◽

Growth Factor ◽

Plasmid Dna ◽

Diabetic Peripheral Neuropathy ◽

Phase Iii ◽

Dna Encoding ◽

Phase Iii Study ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth

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Production of plasmid DNA encoding human hepatocyte growth factor for gene therapy

Biotechnology and Applied Biochemistry ◽

10.1042/ba20060251 ◽

2008 ◽

Vol 49 (1) ◽

pp. 11 ◽

Author(s):

Qinglin Zhang ◽

Jianjing Bi ◽

Fengjun Xiao ◽

Haifeng Duan ◽

Bing Wu ◽

...

Keyword(s):

Gene Therapy ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Plasmid Dna ◽

Human Hepatocyte ◽

Dna Encoding ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth

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517. Prevention of Onset of Parkinson's Disease by In Vivo Gene Transfer of Human Hepatocyte Growth Factor in Primate Model: A Model of Gene Therapy for Parkinson's Disease

Molecular Therapy ◽

10.1016/j.ymthe.2004.06.447 ◽

2004 ◽

Vol 9 ◽

pp. S196

Keyword(s):

Parkinson’S Disease ◽

Gene Therapy ◽

Parkinson's Disease ◽

Growth Factor ◽

Gene Transfer ◽

Primate Model ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth ◽

In Vivo Gene Transfer

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416. Gene Therapy for Parkinsons Disease by In Vivo Plasmid Transfer of Human Hepatocyte Growth Factor in Primate Model

Molecular Therapy ◽

10.1016/j.ymthe.2006.08.480 ◽

2006 ◽

Vol 13 ◽

pp. S160 ◽

Author(s):

Akihiko Ishida ◽

Hiromi Koike ◽

Ryuichi Morishita

Keyword(s):

Gene Therapy ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Plasmid Transfer ◽

Human Hepatocyte ◽

Primate Model ◽

Parkinsons Disease ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth

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Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth

10.1053/jhep.2001.23438 ◽

2001 ◽

Vol 33 (4) ◽

pp. 848-859 ◽

Author(s):

J Yang

Keyword(s):

Growth Factor ◽

Hepatocyte Growth Factor ◽

Plasmid Dna ◽

Body Growth ◽

Dna Encoding ◽

Naked Plasmid ◽

Hepatocyte Growth ◽

Naked Plasmid Dna

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Prevention of onset of Parkinson’s disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson’s disease

Gene Therapy ◽

10.1038/sj.gt.3302810 ◽

2006 ◽

Vol 13 (23) ◽

pp. 1639-1644 ◽

Author(s):

H Koike ◽

A Ishida ◽

M Shimamura ◽

S Mizuno ◽

T Nakamura ◽

...

Keyword(s):

Parkinson’S Disease ◽

Gene Therapy ◽

Parkinson's Disease ◽

Growth Factor ◽

Gene Transfer ◽

Hepatocyte Growth Factor ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth ◽

In Vivo Gene Transfer

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No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2004.01.026 ◽

2004 ◽

Vol 315 (1) ◽

pp. 59-65 ◽

Author(s):

Atsushi Matsuki ◽

Seiji Yamamoto ◽

Hironori Nakagami ◽

Motokuni Aoki ◽

Katsuto Tamai ◽

...

Keyword(s):

Gene Therapy ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Tumor Growth ◽

Plasmid Dna ◽

Intramuscular Injection ◽

Safety Evaluation ◽

Therapeutic Angiogenesis ◽

Hepatocyte Growth

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Gene Therapy Using Plasmid DNA Encoding Vascular Endothelial Growth Factor 164 and Fibroblast Growth Factor 2 Genes for the Treatment of Horse Tendinitis and Desmitis: Case Reports

Frontiers in Veterinary Science ◽

10.3389/fvets.2017.00168 ◽

2017 ◽

Vol 4 ◽

Author(s):

Milomir Kovac ◽

Yaroslav A. Litvin ◽

Ruslan O. Aliev ◽

Elena Yu Zakirova ◽

Catrin S. Rutland ◽

...

Keyword(s):

Gene Therapy ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Plasmid Dna ◽

Case Reports ◽

Fibroblast Growth Factor 2 ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Dna Encoding ◽

Endothelial Growth Factor

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948. Improvement of Symptoms of Parkinson's Disease by In Vivo Gene Transfer of Human Hepatocyte Growth Factor - A Model of Gene Therapy for Parkinson's Disease

Molecular Therapy ◽

10.1016/j.ymthe.2005.07.491 ◽

2005 ◽

Vol 11 ◽

pp. S366-S367

Keyword(s):

Parkinson’S Disease ◽

Gene Therapy ◽

Parkinson's Disease ◽

Growth Factor ◽

Gene Transfer ◽

Hepatocyte Growth Factor ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth ◽

In Vivo Gene Transfer

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Human Hepatocyte Growth Factor (VM202) Gene Therapy via Transendocardial Injection in a Pig Model of Chronic Myocardial Ischemia

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2011.03.004 ◽

2011 ◽

Vol 17 (7) ◽

pp. 601-611 ◽

Author(s):

Emerson C. Perin ◽

Guilherme V. Silva ◽

Deborah C. Vela ◽

Yi Zheng ◽

Fred Baimbridge ◽

...

Keyword(s):

Gene Therapy ◽

Growth Factor ◽

Myocardial Ischemia ◽

Hepatocyte Growth Factor ◽

Human Hepatocyte ◽

Pig Model ◽

Human Hepatocyte Growth Factor ◽

Hepatocyte Growth ◽

Chronic Myocardial Ischemia

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Phase 1/2 Open-label Dose-escalation Study of Plasmid DNA Expressing Two Isoforms of Hepatocyte Growth Factor in Patients With Painful Diabetic Peripheral Neuropathy

Molecular Therapy ◽

10.1038/mt.2013.69 ◽

2013 ◽

Vol 21 (6) ◽

pp. 1279-1286 ◽

Author(s):

Senda Ajroud-Driss ◽

Mark Christiansen ◽

Jeffrey A Allen ◽

John A Kessler

Keyword(s):

Peripheral Neuropathy ◽

Growth Factor ◽

Dose Escalation ◽

Plasmid Dna ◽

Phase 1 ◽

Dose Escalation Study ◽

Painful Diabetic Peripheral Neuropathy ◽

Hepatocyte Growth

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