Endoscopic features of isolated and traditional serrated adenoma‐associated superficially serrated adenomas of the colorectum

2021 ◽  
Author(s):  
Yasuhiko Mizuguchi ◽  
Yusaku Tanaka ◽  
Hourin Cho ◽  
Masau Sekiguchi ◽  
Hiroyuki Takamaru ◽  
...  
Keyword(s):  
Serrated Adenoma ◽  
Traditional Serrated Adenoma ◽  
Serrated Adenomas

Histopathology of Serrated Adenoma, Its Variants, and Differentiation From Conventional Adenomatous and Hyperplastic Polyps

2007 ◽  
Vol 131 (3) ◽  
pp. 440-445
Author(s):  
Shuan C. Li ◽  
Lawrence Burgart
Keyword(s):  
Cancer Progression ◽  
Hyperplastic Polyp ◽  
Routine Practice ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Comparable Rate ◽  
Traditional Serrated Adenoma ◽  
Gastrointestinal Pathology ◽  
Conventional Adenoma ◽  
Serrated Adenomas

Abstract Context.—Serrated adenomas can be morphologically subdivided into traditional and sessile types. They are thought to have a comparable rate of cancer progression like conventional adenomas, but they potentially have a faster rate of growth through methylation pathway(s). They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp. Objective.—To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp. Data Sources.—Relevant articles in peer-review journals and the authors' working experience as practicing surgical pathologists with a specific interest in gastrointestinal pathology. Conclusions.—Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.

TRADITIONAL SERRATED ADENOMA – SIGNS OF SERRATED AND NONSERRATED TYPES OF COLON POLYPS

2019 ◽  
Author(s):  
N Ageykina ◽  
N Oleynikova ◽  
P Malkov ◽  
E Fedorov ◽  
N Danilova ◽  
...  
Keyword(s):  
Colon Polyps ◽  
Serrated Adenoma ◽  
Traditional Serrated Adenoma

Su1940 Do Traditional Serrated Adenoma Coexist With Other Polyp Types?

2015 ◽  
Vol 148 (4) ◽  
pp. S-556
Author(s):  
Sara Hafezi-Bakhtiari ◽  
Stefano Serra ◽  
Richard Colling ◽  
Lai Mun Wang ◽  
Runjan Chetty
Keyword(s):  
Serrated Adenoma ◽  
Traditional Serrated Adenoma

Traditional serrated adenoma withBRAFmutation is associated with synchronous/metachronousBRAF-mutated serrated lesions

2015 ◽  
Vol 68 (6) ◽  
pp. 810-818 ◽  
Author(s):  
Jia-Huei Tsai ◽  
Chien-Hsuan Cheng ◽  
Chien-Chuan Chen ◽  
Yu-Lin Lin ◽  
Liang-In Lin ◽  
...  
Keyword(s):  
Serrated Adenoma ◽  
Traditional Serrated Adenoma ◽  
Serrated Lesions

Traditional serrated adenoma: An enigmatic and aggressive polyp?

2015 ◽  
Vol 82 (6) ◽  
pp. 1094-1096
Author(s):  
Rish K. Pai ◽  
Carole Macaron ◽  
Carol A. Burke
Keyword(s):  
Serrated Adenoma ◽  
Traditional Serrated Adenoma

scholarly journals Slow-Growing Early Adenocarcinoma Arising from Traditional Serrated Adenoma in the Duodenum

2016 ◽  
Vol 10 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Yoon Kyoo Park ◽  
Woo Jin Jeong ◽  
Gab Jin Cheon
Keyword(s):  
Resection Margins ◽  
Tubular Adenocarcinoma ◽  
Solid Organ ◽  
Biopsy Result ◽  
Serrated Adenoma ◽  
Serrated Polyps ◽  
Traditional Serrated Adenoma ◽  
Serrated Polyp ◽  
Type Iv

Serrated polyps are classified into 3 distinct types: hyperplastic polyp, sessile serrated adenoma, or transitional serrated adenoma. A serrated adenoma is a precursor lesion for colorectal carcinoma. Serrated polyps are commonly found in the colorectum but have rarely been described in other parts of the gastrointestinal tract. Serrated adenomas in the small intestine may represent aggressive lesions with high malignant potential, according to some reports. A 66-year-old man with no significant medical history underwent esophagogastroduodenoscopy (EGD) for general examination. He had a 1-cm sized, Yamada type IV polyp, with focal white patch in the second portion of the duodenum. The biopsy result revealed gastric metaplasia and chronic inflammation. He wanted regular follow -up examinations. The follow-up EGDs were done every year. There were no changes in the shape and size of the polyp. The pathologic findings were unchanged. Then, he underwent EGD for general medical check-up again 5 years after the first detection. The size of the polyp was slightly increased. The biopsy result revealed serrated polyp, unclassified. Endoscopic mucosal resection was done. The pathologic result revealed a 0.8 × 0.5-cm sized, well differentiated tubular adenocarcinoma. Carcinomas are multifocally spread on the traditional serrated adenoma, and the proportion of the adenocarcinoma component is approximately 50%. The tumor had invaded the lamina propria but confined to the mucosa. The resection margins were negative, and no lymphovascular invasion or perineural invasion was seen. Abdominal pelvic computed tomography and positron emission tomography showed no other solid organ involvement or metastasis. Surveillance follow-up EGDs were done after 3 months and 1 year. There was no evidence of recurrence.

scholarly journals Sessile serrated adenoma of the appendix: literature review and clinical cases

2020 ◽  
Vol 1 (10) ◽  
pp. 105-109
Author(s):  
L. M. Mikhaleva ◽  
R. A. Vandysheva ◽  
I. S. Kozlov ◽  
O. A. Vasyukova ◽  
K. Yu. Midiber ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Symptoms ◽  
Health Department ◽  
Endoscopic Examination ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
True Incidence ◽  
Moscow City ◽  
Serrated Adenomas ◽  
Clinical Cases

The article contains a literature review of clinical cases describing sessile serrated adenomas in the appendix from 1998 to 2018. Currently, it is still diffi cult to assess the true incidence of this pathology due to the fact that in most cases serrated adenomas are accidental fi ndings diagnosed after removing an inflamed appendix, since often, at small sizes, they do not cause clinical symptoms, do not bother patients and are inaccessible for endoscopic examination (if located behind its orifi ce). In addition, we present 2 clinical cases of sessile serrated adenoma of the appendix in patients who were admitted to the City Clinical Hospital No. 31 of the Moscow City Health Department in 2018 due to acute appendicitis, with a clinical and morphological characteristic, including a molecular genetics study.

scholarly journals INCREASED RISK OF SYNCHRONOUS COLORECTAL LESIONS IN PATIENTS REFERRED FOR ENDOSCOPIC MUCOSAL RESECTION OF LATERAL SPREADING TUMORS

2019 ◽  
Vol 56 (3) ◽  
pp. 276-279 ◽  
Author(s):  
Maria Constanza TORELLA ◽  
Belén DUARTE ◽  
Mariano VILLARROEL ◽  
Juan LASA ◽  
Ignacio ZUBIAURRE
Keyword(s):  
Endoscopic Mucosal Resection ◽  
Bowel Preparation ◽  
Lateral Spreading ◽  
Serrated Adenoma ◽  
Index Lesion ◽  
Mucosal Resection ◽  
Increased Risk ◽  
Lateral Spreading Tumor ◽  
Serrated Adenomas ◽  
Synchronous Lesion

ABSTRACT BACKGROUND: Endoscopic mucosal resection is one of the most frequent therapeutic alternatives for large colorectal lateral spreading tumors. There are few data on the prevalence of synchronous lesions on these patients. OBJECTIVE: To describe the prevalence of synchronous colorectal lesions in patients referred for endoscopic mucosal resection of lateral spreading tumors >20 mm. METHODS: We reviewed the endoscopic database of our Department and identified adult patients who were referred for the resection of a colorectal lateral spreading tumor >20 mm and had a diagnostic colonoscopy performed up to six months before. The proportion of patients with at least one synchronous lesion was estimated. The following features were compared between patients with and without synchronous lesions: age, gender, bowel preparation quality and cecal intubation on index colonoscopy and therapeutic colonoscopy, serrated adenoma as index lesion. RESULTS: From December 2016 to November 2017, we identified 70 patients who fulfilled inclusion criteria. Median size of lesions was 25 mm (20-45). Eighty percent were located in the right colon and 35.71% were serrated adenomas. Synchronous lesion rate was 38.57%. Bowel preparation quality was similar in both groups when comparing both index and therapeutic colonoscopies. Patients with synchronous lesions had a higher proportion of serrated adenoma as index lesion than patients without synchronous lesions [51.85% vs 25.58%, OR 3.13 (1.13-8.68), P=0.03]. CONCLUSION: We found a high prevalence of synchronous lesions among patients with a large colorectal lateral spreading tumor. This risk seems to be increased if index lesions are serrated adenomas.

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