The dynamic changes of zinc transporter 8 autoantibodies in Czech children from the onset of Type 1 diabetes mellitus

Zinc, an important micronutrient for the storage, structural stabilization, secretion and action of insulin, is present in highest concentration in pancreas. The transport of zinc occurs through the zinc transporter-8 (ZnT8) to the insulin secretory vesicles. Zinc Transporter-8 Autoantibodies (ZnT8A) has been found to be associated with Type 2 Diabetes Mellitus. Recently it is recognized as a new autoantigen in Type 1 Diabetes Mellitus (T1DM) and its autoantibodies have been found in 50-60% of individuals with T1DM. Moreover, ZnT8A exhibit humoral auto reactivity which is not displayed by any of the other islet autoantigen like glutamine decarboxylase (GAD), insulin or tyrosine phosphate-related molecules (IA-2). Immunity against ZnT8 is dependent on clinical characteristics, which may provide evidence for early recognition highlighting the importance of this transporter in the pathogenesis of T1DM. Information regarding this article was retrieved through PubMed, Google Scholar and other search engines available in the University by using the keywords zinc, ZnT, ZnT8, SLC30A8 (Solute carrier 30 member 8) and Type 1 Diabetes Mellitus. Information was gathered through original researches, reviews and epidemiological studies published up to August 2019.The aim of this review is to summarize the emerging role of ZnT8A in diagnosis and understanding the genetic basis of Type 1 Diabetes Mellitus.

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Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus

Journal of Diabetes Investigation ◽

10.1111/jdi.12441 ◽

2016 ◽

Vol 7 (4) ◽

pp. 459-465 ◽

Cited By ~ 13

Author(s):

Bo Yi ◽

Gan Huang ◽

Zhiguang Zhou

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Type 1 Diabetes Mellitus ◽

Zinc Transporter ◽

Zinc Transporter 8

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Immunological predictors of type 1 diabetes mellitus (literature review)

Diabetes Mellitus ◽

10.14341/dm12308 ◽

2021 ◽

Vol 24 (2) ◽

pp. 167-174

Author(s):

K. G. Korneva ◽

L. G. Strongin ◽

V. E. Zagainov

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Current Knowledge ◽

Diagnostic Value ◽

Individual Variability ◽

Current Data ◽

Dynamic Changes ◽

Chronic Autoimmune Disease

Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin deficiency due β-cell destruction and following hyperglycaemia. Specific markers of T1DM are pancreatic islet-targeting autoantibodies that are found months to years before symptom onset, and can be used to identify individuals who are at risk of developing T1DM.Aim: The study is aimed at the review of current knowledge of diabetes-related autoantibodies as biomarkers of T1DM.Materials and methods: Foreign and national clinical studies on this topic were included. PubMed, Medline and eLibrary were searched.Results: Modern ideas about known diabetes-specific autoantibodies as markers of autoimmune inflammation of β-cells of the pancreas were discussed. The analysis of their independent diagnostic value in predicting the occurrence of T1DM were carried out.Conclusion: There is no unified concept in the literature on this issue. Current data on autoantibodies in T1DM show a significant individual variability in the timing, dynamic changes and autoantibody composition in T1DM progression.

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