The Additive Diagnostic Role of Coronary Flow Reserve in Noninvasive Evaluation of Coronary Stenosis on Left Descending Artery Previously Detected by Multislice Computed Tomography

2012 ◽  
Vol 30 (3) ◽  
pp. 338-344 ◽  
Author(s):  
Zorica Mladenovic ◽  
Ana Djordjevic-Dikic ◽  
Dragan Tavciovski ◽  
Andjelka Ristic Angelkov ◽  
Zoran Jovic ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Flow Reserve ◽  
Coronary Stenosis ◽  
Coronary Flow ◽  
Multislice Computed Tomography ◽  
Noninvasive Evaluation ◽  
Flow Reserve ◽  
Diagnostic Role

Reduced Coronary Flow Reserve in Hypercholesterolemic Patients Without Overt Coronary Stenosis

Circulation ◽  
1996 ◽  
Vol 94 (12) ◽  
pp. 3232-3238 ◽  
Author(s):  
Ikuo Yokoyama ◽  
Tohru Ohtake ◽  
Shin-ichi Momomura ◽  
Junichi Nishikawa ◽  
Yasuhito Sasaki ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Stenosis ◽  
Coronary Flow ◽  
Flow Reserve

scholarly journals Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain

2007 ◽  
Vol 71 (6) ◽  
pp. 891-896 ◽  
Author(s):  
Yu Kataoka ◽  
Satoshi Nakatani ◽  
Norio Tanaka ◽  
Hideaki Kanzaki ◽  
Satoshi Yasuda ◽  
...  
Keyword(s):  
Chest Pain ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Flow Reserve

Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease

2008 ◽  
Vol 131 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Attila Nemes ◽  
Tamás Forster ◽  
Marcel L. Geleijnse ◽  
Osama I.I. Soliman ◽  
Folkert J. ten Cate ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Suspected Coronary Artery Disease ◽  
Aortic Atherosclerosis ◽  
Prognostic Role ◽  
Flow Reserve ◽  
Artery Disease

scholarly journals Role of sex hormones in modulating myocardial perfusion and coronary flow reserve

2022 ◽  
Author(s):  
Ahmed Haider ◽  
Susan Bengs ◽  
Angela Portmann ◽  
Alexia Rossi ◽  
Hazem Ahmed ◽  
...  
Keyword(s):  
Sex Differences ◽  
Myocardial Perfusion ◽  
Sex Hormones ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Testosterone Levels ◽  
Flow Reserve

Abstract Background A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex hormones in modulating myocardial perfusion and coronary flow reserve (CFR) is currently unclear. The aim of our study was to assess the impact of female and male sex hormones on myocardial perfusion and CFR. Methods Rest and stress myocardial perfusion imaging (MPI) was conducted by small animal positron emission tomography (PET) with [18F]flurpiridaz in a total of 56 mice (7–8 months old) including gonadectomized (Gx) and sham-operated males and females, respectively. Myocardial [18F]flurpiridaz uptake (% injected dose per mL, % ID/mL) was used as a surrogate for myocardial perfusion at rest and following intravenous regadenoson injection, as previously reported. Apparent coronary flow reserve (CFRApp) was calculated as the ratio of stress and rest myocardial perfusion. Left ventricular (LV) morphology and function were assessed by cardiac magnetic resonance (CMR) imaging. Results Orchiectomy resulted in a significant decrease of resting myocardial perfusion (Gx vs. sham, 19.4 ± 1.0 vs. 22.2 ± 0.7 % ID/mL, p = 0.034), while myocardial perfusion at stress remained unchanged (Gx vs. sham, 27.5 ± 1.2 vs. 27.3 ± 1.2 % ID/mL, p = 0.896). Accordingly, CFRApp was substantially higher in orchiectomized males (Gx vs. sham, 1.43 ± 0.04 vs. 1.23 ± 0.05, p = 0.004), and low serum testosterone levels were linked to a blunted resting myocardial perfusion (r = 0.438, p = 0.020) as well as an enhanced CFRApp (r = −0.500, p = 0.007). In contrast, oophorectomy did not affect myocardial perfusion in females. Of note, orchiectomized males showed a reduced LV mass, stroke volume, and left ventricular ejection fraction (LVEF) on CMR, while no such effects were observed in oophorectomized females. Conclusion Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.

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