Prediction of subtle left ventricular systolic dysfunction in homozygous and heterozygous familial hypercholesterolemia: Genetic analyses and speckle tracking echocardiography study

2018 ◽  
Vol 35 (9) ◽  
pp. 1289-1299 ◽  
Author(s):  
Erhan Saracoglu ◽  
Salih Kılıç ◽  
Ertan Vuruşkan ◽  
Irfan Düzen ◽  
Yusuf Çekici ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Genetic Analyses ◽  
Heterozygous Familial Hypercholesterolemia

scholarly journals Fragmented QRS as an early predictor of left ventricular systolic dysfunction in healthy individuals: A nested case-control study in the era of speckle tracking echocardiography

2020 ◽  
Author(s):  
Mohammad Hossein Nikoo ◽  
Zahra Jamali ◽  
Iman Razeghian-Jahromi ◽  
Mehrab Sayadi ◽  
Firoozeh Abtahi
Keyword(s):  
Ejection Fraction ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Diagnostic Methods ◽  
Ventricular Systolic Dysfunction ◽  
Control Groups ◽  
Fragmented Qrs

Abstract Background: The burden of cardiovascular diseases have been become a concerning health challenge throughout the world. Stopping this condition needs applying early, yet inexpensive diagnostic methods. The aim of this study is to evaluate the capacity of fragmented QRS (fQRS) on 12-lead EKG for detecting left ventricular dysfunction in healthy individuals.Methods: Out of 500 healthy participants without detected cardiovascular disorders from Shiraz Heart Study cohort, 20 subjects diagnosed with fQRS (case) and 20 peers without fQRS (control) were participated. Global longitudinal strain was measured by speckle tracking echocardiography for two groups. Comparison was made between case and control groups by using chi-square or independent sample t-test or ANOVA. P value of less than 5% considered statistical significance. Results: There was no difference between the case and the control groups in terms of age, gender, ejection fraction, left ventricular volume and dimensions. Out of 40 subjects, 14 had reduced GLS (≤20%) with 10 of them had fQRS. GLS in the case group was significantly lower than in the control group.Conclusions: Apparent healthy subjects with fQRS diagnosed with left ventricular systolic dysfunction with respect to GLS despite normal ejection fraction. It seems that EKG, as one of the simplest way toward assessing heart function, could be a prominent informative clue to detect high-risk individuals among healthy population in advance.

Sign in / Sign up

Export Citation Format

Share Document