Perineuronal nets affect parvalbumin expression in GABAergic neurons of the mouse hippocampus

2014 ◽  
Vol 41 (3) ◽  
pp. 368-378 ◽  
Author(s):  
J. Yamada ◽  
T. Ohgomori ◽  
S. Jinno
Keyword(s):  
Gabaergic Neurons ◽  
Perineuronal Nets ◽  
Mouse Hippocampus

The development of perineuronal nets around parvalbumin gabaergic neurons in the medial prefrontal cortex and basolateral amygdala of rats.

2017 ◽  
Vol 131 (4) ◽  
pp. 289-303 ◽  
Author(s):  
Kathryn D. Baker ◽  
Arielle R. Gray ◽  
Rick Richardson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Gabaergic Neurons ◽  
Perineuronal Nets

Effects of long-term ethanol consumption on gabaergic neurons in the mouse hippocampus: A quantitative immunocytochemical study

1986 ◽  
Vol 18 (4) ◽  
pp. 377-384 ◽  
Author(s):  
L. Lescaudron ◽  
P. Seguela ◽  
M. Geffard ◽  
A. Verna
Keyword(s):  
Ethanol Consumption ◽  
Gabaergic Neurons ◽  
Immunocytochemical Study ◽  
Mouse Hippocampus

scholarly journals Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Ruggiero Francavilla ◽  
Vincent Villette ◽  
Xiao Luo ◽  
Simon Chamberland ◽  
Einer Muñoz-Pino ◽  
...  
Keyword(s):  
Long Range ◽  
Gabaergic Neurons ◽  
Network State ◽  
State Dependent ◽  
Mouse Hippocampus

scholarly journals Lateralized expression of cortical perineuronal nets during maternal experience is dependent on MECP2

2019 ◽  
Author(s):  
Billy Y.B. Lau ◽  
Dana E. Layo ◽  
Brett Emery ◽  
Matthew Everett ◽  
Anushree Kumar ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Synaptic Plasticity ◽  
Adult Female ◽  
Social Contexts ◽  
Gabaergic Neurons ◽  
Perineuronal Nets ◽  
Critical Periods ◽  
Early Postnatal Development ◽  
Female Mice ◽  
Maternal Experience

Cortical neuronal circuits along the sensorimotor pathways are shaped by experience during critical periods of heightened plasticity in early postnatal development. After closure of critical periods, measured histologically by the formation and maintenance of extracellular matrix structures called perineuronal nets (PNNs), the adult mouse brain exhibits restricted plasticity and maturity. Mature PNNs are typically considered to be stable structures that restrict synaptic plasticity on cortical parvalbumin+ GABAergic neurons. Changes in environment (i.e. novel behavioral training) or social contexts (i.e. motherhood) are known to elicit synaptic plasticity in relevant neural circuitry. However, little is known about concomitant changes in the PNNs surrounding the cortical parvalbumin+ GABAergic neurons. Here, we show novel changes in PNN density in the primary somatosensory cortex (SS1) of adult female mice after maternal experience, using systematic microscopy analysis of a whole brain region. On average, PNNs were increased in the right barrel field and decreased in the left forelimb regions. Individual mice had left hemisphere dominance in PNN density. Using adult female mice deficient in methyl-CpG-binding protein 2 (MECP2), an epigenetic regulator involved in regulating experience-dependent plasticity, we found that MECP2 is critical for this precise and dynamic expression of PNN. Adult naïve Mecp2-heterozygous females (Het) had increased PNN density in specific subregions in both hemispheres before maternal experience. The laterality in PNN expression seen in naïve Het was lost after maternal experience, suggesting possible intact mechanisms for plasticity. Together, our results identify subregion and hemisphere-specific alterations in PNN expression in adult females, suggesting extracellular matrix plasticity as a possible neurobiological mechanism for adult behaviors in rodents.

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