The BDNF val66met polymorphism is associated with decreased use of landmarks and decreased fMRI activity in the hippocampus during virtual navigation

2021 ◽  
Author(s):  
Greg L. West ◽  
Kyoko Konishi ◽  
Kathleen MacDonald ◽  
Anjie Ni ◽  
Ridha Joober ◽  
...  
Keyword(s):  
Virtual Navigation ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism

scholarly journals The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Angela Shiratsu Yamada ◽  
Flavia Tasmim Techera Antunes ◽  
Camila Ferraz ◽  
Alessandra Hubner de Souza ◽  
Daniel Simon
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Neurotrophic Factor ◽  
Central Sensitization ◽  
Low Back ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Brain

Abstract Background The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). Methods A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. Results The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. Conclusion The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied.

scholarly journals Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain

2021 ◽  
Vol 30 ◽  
pp. 102576
Author(s):  
Wei-Chi Li ◽  
Hsiang-Tai Chao ◽  
Ming-Wei Lin ◽  
Horng-Der Shen ◽  
Li-Fen Chen ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Menstrual Pain ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism

Semantic but not phonological verbal fluency associated with BDNF Val66Met polymorphism in schizophrenia

2009 ◽  
Vol 150B (3) ◽  
pp. 441-442 ◽  
Author(s):  
O. Kebir ◽  
F. Mouaffak ◽  
M. Chayet ◽  
S. Leroy ◽  
S. Tordjman ◽  
...  
Keyword(s):  
Verbal Fluency ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism

scholarly journals Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress

2017 ◽  
Vol 79 ◽  
pp. 13-19 ◽  
Author(s):  
Rong Jiang ◽  
Michael A. Babyak ◽  
Beverly H. Brummett ◽  
Ilene C. Siegler ◽  
Cynthia M. Kuhn ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Mental Stress ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Cortisol Responses ◽  
Bdnf Val66met Polymorphism
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