scholarly journals Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain

2021 ◽  
Vol 30 ◽  
pp. 102576
Author(s):  
Wei-Chi Li ◽  
Hsiang-Tai Chao ◽  
Ming-Wei Lin ◽  
Horng-Der Shen ◽  
Li-Fen Chen ◽  
...  
2018 ◽  
Vol 12 ◽  
Author(s):  
Intan Low ◽  
Po-Chih Kuo ◽  
Cheng-Lin Tsai ◽  
Yu-Hsiang Liu ◽  
Ming-Wei Lin ◽  
...  

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Angela Shiratsu Yamada ◽  
Flavia Tasmim Techera Antunes ◽  
Camila Ferraz ◽  
Alessandra Hubner de Souza ◽  
Daniel Simon

Abstract Background The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). Methods A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. Results The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. Conclusion The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied.


2009 ◽  
Vol 150B (3) ◽  
pp. 441-442 ◽  
Author(s):  
O. Kebir ◽  
F. Mouaffak ◽  
M. Chayet ◽  
S. Leroy ◽  
S. Tordjman ◽  
...  

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