scholarly journals The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Angela Shiratsu Yamada ◽  
Flavia Tasmim Techera Antunes ◽  
Camila Ferraz ◽  
Alessandra Hubner de Souza ◽  
Daniel Simon
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Neurotrophic Factor ◽  
Central Sensitization ◽  
Low Back ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Brain

Abstract Background The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). Methods A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. Results The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. Conclusion The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied.

Central Sensitization and Altered Central Pain Processing in Chronic Low Back Pain

2013 ◽  
Vol 29 (7) ◽  
pp. 625-638 ◽  
Author(s):  
Nathalie A. Roussel ◽  
Jo Nijs ◽  
Mira Meeus ◽  
Veit Mylius ◽  
Cécile Fayt ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Central Sensitization ◽  
Pain Processing ◽  
Central Pain ◽  
Low Back ◽  
Central Pain Processing

scholarly journals Difference in the impact of central sensitization on pain-related symptoms between patients with chronic low back pain and knee osteoarthritis

2019 ◽  
Vol Volume 12 ◽  
pp. 1757-1765 ◽  
Author(s):  
Akira Mibu ◽  
Tomohiko Nishigami ◽  
Katsuyoshi Tanaka ◽  
Masahiro Manfuku ◽  
Satoko Yono
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Knee Osteoarthritis ◽  
Chronic Low Back Pain ◽  
Central Sensitization ◽  
Low Back ◽  
The Impact

Phenotype matters: the importance of age, affect, medication, and pain characterization in the brain morphometry of chronic low back pain

2013 ◽  
Vol 14 (4) ◽  
pp. S52 ◽  
Author(s):  
A. Dolman ◽  
M. Loggia ◽  
R. Edwards ◽  
J. Kong ◽  
R. Gollub ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Brain Morphometry ◽  
The Brain

scholarly journals Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village

2021 ◽  
Vol Volume 14 ◽  
pp. 1271-1280
Author(s):  
Koji Akeda ◽  
Norihiko Takegami ◽  
Junichi Yamada ◽  
Tatsuhiko Fujiwara ◽  
Akinobu Nishimura ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Central Sensitization ◽  
Population Based ◽  
Low Back ◽  
Population Based Study ◽  
Mountain Village

scholarly journals Illness Behavior in Patients With Chronic Low Back Pain and Activation of the Affective Circuitry of the Brain

2014 ◽  
Vol 76 (6) ◽  
pp. 413-421 ◽  
Author(s):  
Donna M. Lloyd ◽  
Gordon Findlay ◽  
Neil Roberts ◽  
Turo Nurmikko
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Illness Behavior ◽  
Low Back ◽  
The Brain

scholarly journals Effect of Yoga on Pain, Brain-Derived Neurotrophic Factor, and Serotonin in Premenopausal Women with Chronic Low Back Pain

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Moseon Lee ◽  
Woongjoon Moon ◽  
Jaehee Kim
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Neurotrophic Factor ◽  
Premenopausal Women ◽  
Brain Derived Neurotrophic Factor ◽  
Control Group ◽  
Low Back ◽  
Yoga Group ◽  
Serum Bdnf

Background. Serotonin and brain-derived neurotrophic factor (BDNF) are known to be modulators of nociception. However, pain-related connection between yoga and those neuromodulators has not been investigated. Therefore, we aimed to evaluate the effect of yoga on pain, BDNF, and serotonin.Methods. Premenopausal women with chronic low back pain practiced yoga three times a week for 12 weeks. At baseline and after 12 weeks, back pain intensity was measured using visual analogue scale (VAS), and serum BDNF and serotonin levels were evaluated. Additionally, back flexibility and level of depression were assessed.Results. After 12-week yoga, VAS decreased in the yoga group (P<0.001), whereas it increased (P<0.05) in the control group. Back flexibility was improved in the yoga group (P<0.01). Serum BDNF increased in the yoga group (P<0.01), whereas it tended to decrease in the control group (P=0.05). Serum serotonin maintained in the yoga group, while it reduced (P<0.01) in the control group. The depression level maintained in the yoga group, whereas it tended to increase in the control group (P=0.07).Conclusions. We propose that BDNF may be one of the key factors mediating beneficial effects of yoga on chronic low back pain.

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