Spectral electroencephalography profile of rapid eye movement sleep at sleep onset in narcolepsy type 1

2016 ◽  
Vol 24 (2) ◽  
pp. 334-340 ◽  
Author(s):  
F. Pizza ◽  
R. Ferri ◽  
S. Vandi ◽  
F. Rundo ◽  
M. Iloti ◽  
...  
Keyword(s):  
Eye Movement ◽  
Sleep Onset ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep

First rapid eye movement sleep periods and sleep-onset rapid eye movement periods in sleep-stage sequencing of hypersomnias

2013 ◽  
Vol 14 (9) ◽  
pp. 897-901 ◽  
Author(s):  
Panagis Drakatos ◽  
Christopher A. Kosky ◽  
Sean E. Higgins ◽  
Rexford T. Muza ◽  
Adrian J. Williams ◽  
...  
Keyword(s):  
Eye Movement ◽  
Sleep Stage ◽  
Sleep Onset ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep

Immune Mediators in Allergic Rhinitis and Sleep

2002 ◽  
Vol 126 (6) ◽  
pp. 607-613 ◽  
Author(s):  
Helene J. Krouse ◽  
Jean E. Davis ◽  
John H. Krouse
Keyword(s):  
Eye Movement ◽  
Sleep Onset ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Serum Cytokines ◽  
Immune Mediators ◽  
Allergic Symptoms ◽  
Low Levels ◽  
Serial Measurements ◽  
Polysomnographic Recording

OBJECTIVE: Our study goal was to examine polysomnography, indices of sleep and allergy, and serum and nasal cytokines in allergic and nonallergic subjects. STUDY DESIGN AND SETTING: In this descriptive, exploratory study, 4 allergic and 4 nonallergic subjects underwent 2 nights of polysomnographic recording with serial measurements of cytokines and completed measures of sleep quality and allergic symptoms. RESULTS: Three serum cytokines (interleukin (IL)-1β, IL-4, and IL-10) were higher in allergic subjects and were termed proallergic. Three serum cytokines (IL-1ra, IL-2, and IL-12) were higher in nonallergic subjects and were termed allergy inhibitory. Proallergic serum cytokines correlated with increased latency to rapid eye movement sleep, decreased time in rapid eye movement sleep, and decreased latency to sleep onset. Low levels of allergy-inhibitory serum cytokines were associated with increased allergic symptoms. CONCLUSIONS: Differences in serum cytokines between allergic and nonallergic individuals are associated with variations in polysomnography and allergic symptoms. SIGNIFICANCE: Understanding these mechanisms may suggest novel approaches to alleviating drowsiness and other symptoms in allergic patients.

scholarly journals Nocturnal Sleep Onset Rapid Eye Movement Sleep Periods as a Predictor of the Severity of Narcolepsy in Korea

2020 ◽  
Vol 11 (1) ◽  
pp. 19-24
Author(s):  
Jihyun Song ◽  
Tae-Won Kim ◽  
Sung Min Kim ◽  
Yoo Hyun Um ◽  
Jong-Hyun Jeong ◽  
...  
Keyword(s):  
Eye Movement ◽  
Sleep Onset ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Nocturnal Sleep

Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice

SLEEP ◽  
2021 ◽  
Author(s):  
Mahesh K Kaushik ◽  
Kosuke Aritake ◽  
Yoan Cherasse ◽  
Aya Imanishi ◽  
Takashi Kanbayashi ◽  
...  
Keyword(s):  
Eye Movement ◽  
Sleep Onset ◽  
Nrem Sleep ◽  
Rapid Eye Movement ◽  
Wild Type ◽  
Receptor Antagonists ◽  
Experimental Animals ◽  
Hypothalamic Neuropeptides

Abstract Orexins/hypocretins are hypothalamic neuropeptides that promote and stabilize wakefulness by binding to the orexin receptor type-1 (OX1R) and type-2 (OX2R). Disruption of orexinergic signaling results in the sleep disorder narcolepsy in mice, rats, dogs, and humans. The orexin receptor antagonist suvorexant promotes sleep by blocking both OX1R and OX2R. Whereas suvorexant has been clinically approved for the treatment of insomnia because it is well tolerated in experimental animals as well as in human patients, a logical question remains as to why orexin receptor antagonists do not induce overt narcolepsy-like symptoms. Here we show that acute and chronic suvorexant promotes both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep without inducing cataplexy in mice. Interestingly, chronic suvorexant increases OX2R mRNA and decreases orexin mRNA and peptide levels, which remain low long after termination of suvorexant administration. When mice are chronically treated with suvorexant and then re-challenged with the antagonist after a 1-week washout, however, cataplexy and sleep-onset REM (SOREM) are observed, which are exacerbated by chocolate administration. Heterozygous orexin knockout mice, with lower brain orexin levels, show cataplexy and SOREM after acute suvorexant administration. Furthermore, we find that acute suvorexant can induce cataplexy and SOREM in wild-type mice when co-administered with chocolate under stress-free (temporally anesthetized) conditions. Taken together, these results suggest that suvorexant can inhibit orexin synthesis resulting in susceptibility to narcolepsy-like symptoms in mice under certain conditions.

Dissociated rapid eye movement sleep dream experiences in type 1 narcolepsy: a case report

2016 ◽  
Vol 19 ◽  
pp. 150-152 ◽  
Author(s):  
C. Bellucci ◽  
S. Vandi ◽  
M. Iloti ◽  
F. Pizza ◽  
P.M. Russo ◽  
...  
Keyword(s):  
Case Report ◽  
Eye Movement ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep

scholarly journals Sleep in Huntington’s disease: a systematic review and meta-analysis of polysomongraphic findings

SLEEP ◽  
2019 ◽  
Vol 42 (10) ◽  
Author(s):  
Ye Zhang ◽  
Rong Ren ◽  
Linghui Yang ◽  
Junying Zhou ◽  
Yun Li ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Eye Movement ◽  
Meta Analysis ◽  
Sleep Onset ◽  
Repeat Length ◽  
Cag Repeat ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Wake Time

Abstract Study Objectives Disturbed overnight sleep is a prominent feature of advanced stage Huntington’s disease (HD). Several polysomnography (PSG) studies have reported significant changes of sleep in HD patients, but the findings are not unequivocal. To date, no meta-analysis has investigated the PSG changes in HD patients. The present study meta-analyzed results from studies examining the PSG changes in HD patients compared with controls. Methods A literature search performed in MEDLINE, EMBASE, All EBM databases, PsycINFO, and CINAHL databases identified seven studies involving 152 HD patients and 144 controls which were included in our meta-analysis. Results Pooled results indicated decreased sleep efficiency, percentage of slow wave sleep and rapid eye movement sleep, and increased percentage of N1 sleep, wake time after sleep onset, and rapid eye movement sleep latency in HD patients compared with controls. We found high heterogeneity in the effect sizes and no indication of systematic publication biases across studies. Meta-regression analyses showed that some of the heterogeneity was explained by age, body mass index (BMI), CAG repeat length, and disease severity of HD patients. Conclusions Our study showed that polysomnographic abnormalities are present in HD. Our findings also underscore the need for a comprehensive PSG assessment of sleep changes in patients with HD. Furthermore, the effects of age, BMI and CAG repeat length on sleep changes should be carefully considered and closely monitored in the management of HD.

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