Participation of extracellular signal-regulated kinases 1/2 in osteoblast and adipocyte differentiation of mesenchymal stem cells grown on titanium surfaces

2017 ◽  
Vol 125 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Heitor F. Silva ◽  
Rodrigo P. F. Abuna ◽  
Helena B. Lopes ◽  
Marcelo S. Francischini ◽  
Paulo T. de Oliveira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipocyte Differentiation ◽  
Extracellular Signal ◽  
Titanium Surfaces

Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells

2021 ◽  
Author(s):  
Ruriko Sekiya-Aoyama ◽  
Yoshinori Arisaka ◽  
Masahiro Hakariya ◽  
Hiroki Masuda ◽  
Takanori Iwata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Functional Groups ◽  
Molecular Mobility ◽  
Adipocyte Differentiation ◽  
Negative Charge ◽  
Dual Effect ◽  
Independent Parameters

Mesenchymal stem cells on polyrotaxane surfaces underwent enhanced osteoblast and adipocyte differentiation. Two independent parameters, high molecular mobility and negative charge on the surfaces, may not offset the effect to promote both differentiation.

Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females

Bone ◽  
2006 ◽  
Vol 39 (1) ◽  
pp. 181-188 ◽  
Author(s):  
Basem M. Abdallah ◽  
Mandana Haack-Sørensen ◽  
Trine Fink ◽  
Moustapha Kassem
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteoblast Differentiation ◽  
Adipocyte Differentiation

scholarly journals The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes

2018 ◽  
Vol 19 (7) ◽  
pp. 2081 ◽  
Author(s):  
Christian Carpéné ◽  
Héctor Pejenaute ◽  
Raquel del Moral ◽  
Nathalie Boulet ◽  
Elizabeth Hijona ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Phenolic Compounds ◽  
Glucose Transport ◽  
Adipocyte Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Herbal Remedies ◽  
Metabolic Complications ◽  
Obesity And Diabetes

Phenolic compounds are among the most investigated herbal remedies, as is especially the case for resveratrol. Many reports have shown its anti-aging properties and the ability to reduce obesity and diabetes induced by high-fat diet in mice. However, such beneficial effects hardly translate from animal models to humans. The scientific community has therefore tested whether other plant phenolic compounds may surpass the effects of resveratrol. In this regard, it has been reported that piceatannol reproduces in rodents the anti-obesity actions of its parent polyphenol. However, the capacity of piceatannol to inhibit adipocyte differentiation in humans has not been characterized so far. Here, we investigated whether piceatannol was antiadipogenic and antilipogenic in human preadipocytes. Human mesenchymal stem cells (hMSC), isolated from adipose tissues of lean and obese individuals, were differentiated into mature adipocytes with or without piceatannol, and their functions were explored. Fifty μM of piceatannol deeply limited synthesis/accumulation of lipids in both murine and hMSC-derived adipocytes. Interestingly, this phenomenon occurred irrespective of being added at the earlier or later stages of adipocyte differentiation. Moreover, piceatannol lowered glucose transport into adipocytes and decreased the expression of key elements of the lipogenic pathway (PPARγ, FAS, and GLUT4). Thus, the confirmation of the antiadipogenic properties of piceatanol in vitro warrants the realization of clinical studies for the application of this compound in the treatment of the metabolic complications associated with obesity.

cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK

Neuroreport ◽  
2005 ◽  
Vol 16 (12) ◽  
pp. 1357-1361 ◽  
Author(s):  
Sung-Soo Kim ◽  
Jung-Mi Choi ◽  
Ji-Won Kim ◽  
Dong-Sik Ham ◽  
Sung-Ho Ghil ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuronal Differentiation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Apelin: an endogenous peptide essential for cardiomyogenic differentiation of mesenchymal stem cells via activating extracellular signal-regulated kinase 1/2 and 5

2016 ◽  
Vol 40 (5) ◽  
pp. 501-514 ◽  
Author(s):  
Li Wang ◽  
Zhi-Ming Zhu ◽  
Ning-Kun Zhang ◽  
Zhi-Rong Fang ◽  
Xiao-Hong Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Endogenous Peptide ◽  
Cardiomyogenic Differentiation ◽  
Extracellular Signal

Titanium Surfaces Functionalized with siMIR31HG Promote Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

2018 ◽  
Vol 4 (8) ◽  
pp. 2986-2993 ◽  
Author(s):  
Yiping Huang ◽  
Yunfei Zheng ◽  
Yongxiang Xu ◽  
Xiaobei Li ◽  
Yan Zheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Marrow Mesenchymal Stem Cells ◽  
Titanium Surfaces

Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

2018 ◽  
Vol 500 (3) ◽  
pp. 682-690 ◽  
Author(s):  
Vuong Cat Khanh ◽  
Amin Firman Zulkifli ◽  
Chiho Tokunaga ◽  
Toshiharu Yamashita ◽  
Yuji Hiramatsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipocyte Differentiation ◽  
Sirtuin 1 ◽  
Beige Adipocyte

Genome‐wide DNA‐methylation profiles in human bone marrow mesenchymal stem cells on titanium surfaces

2019 ◽  
Vol 127 (3) ◽  
pp. 196-209
Author(s):  
Mingyue Lyu ◽  
Yunfei Zheng ◽  
Lingfei Jia ◽  
Yan Zheng ◽  
Yanping Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Genome Wide ◽  
Marrow Mesenchymal Stem Cells ◽  
Titanium Surfaces
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