Sex differences in olfactory social recognition memory in meadow voles, Microtus pennsylvanicus

Ethology ◽  
2020 ◽  
Vol 126 (10) ◽  
pp. 993-1003
Author(s):  
Kelsey E. Clark ◽  
Kaitlynn A. Messler ◽  
Michael H. Ferkin
Keyword(s):  
Sex Differences ◽  
Recognition Memory ◽  
Microtus Pennsylvanicus ◽  
Social Recognition ◽  
Meadow Voles ◽  
Social Recognition Memory

scholarly journals Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kana Okada ◽  
Kayo Nishizawa ◽  
Tomoko Kobayashi ◽  
Shogo Sakata ◽  
Kouichi Hashimoto ◽  
...  
Keyword(s):  
Social Interaction ◽  
Recognition Memory ◽  
Basal Forebrain ◽  
Social Behaviour ◽  
Cholinergic Neurons ◽  
Social Recognition ◽  
Social Ability ◽  
Cell Groups ◽  
Cholinergic Cell ◽  
Social Recognition Memory

AbstractSocial behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer’s disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber test. Elimination of cholinergic neurons in the medial septum (MS) and vertical diagonal band of Broca (vDB) caused impairment in social interaction, whereas ablating cholinergic neurons in the nucleus basalis magnocellularis (NBM) impaired social recognition memory. These impairments were restored by treatment with cholinesterase inhibitors, leading to cholinergic system activation. Our findings indicate distinct roles of MS/vDB and NBM cholinergic neurons in social interaction and social recognition memory, suggesting that cholinergic dysfunction may explain social ability deficits associated with AD symptoms.

scholarly journals Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 555
Author(s):  
Barbara Rani ◽  
Bruna Silva-Marques ◽  
Rob Leurs ◽  
Maria Beatrice Passani ◽  
Patrizio Blandina ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Histamine Release ◽  
Histidine Decarboxylase ◽  
Acetylcholinesterase Inhibitor ◽  
Social Recognition ◽  
Amnesic Effect ◽  
Brain Histamine ◽  
Monogamous Species ◽  
Social Recognition Memory

The ability of recognizing familiar conspecifics is essential for many forms of social interaction including reproduction, establishment of dominance hierarchies, and pair bond formation in monogamous species. Many hormones and neurotransmitters have been suggested to play key roles in social discrimination. Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. Impairments of LTM, but not STM, were observed in histamine-deprived animals, either chronically (Hdc−/− mice lacking the histamine-synthesizing enzyme histidine decarboxylase) or acutely (mice treated with the HDC irreversible inhibitor α-fluoromethylhistidine). On the contrary, restriction of histamine release induced by stimulation of the H3R agonist (VUF16839) impaired both STM and LTM. H3R agonism-induced amnesic effect was prevented by pre-treatment with donepezil, an acetylcholinesterase inhibitor. The blockade of the H3R with ciproxifan, which in turn augmented histamine release, resulted in a procognitive effect. In keeping with this hypothesis, the procognitive effect of ciproxifan was absent in both Hdc−/− and αFMH-treated mice. Our results suggest that brain histamine is essential for the consolidation of LTM but not STM in the social recognition test. STM impairments observed after H3R stimulation are probably related to their function as heteroreceptors on cholinergic neurons.

Brain regions activated during consolidation of social recognition memory

2010 ◽  
Vol 68 ◽  
pp. e291
Author(s):  
Toshiyuki Tanimizu ◽  
Kazune Kadoma ◽  
Yue Zhang ◽  
Hotaka Fukushima ◽  
Satoshi Kida
Keyword(s):  
Recognition Memory ◽  
Brain Regions ◽  
Social Recognition ◽  
Social Recognition Memory

scholarly journals Social recognition memory: Influence of age, sex, and ovarian hormonal status

2007 ◽  
Vol 92 (5) ◽  
pp. 881-888 ◽  
Author(s):  
Julie A. Markham ◽  
Janice M. Juraska
Keyword(s):  
Recognition Memory ◽  
Social Recognition ◽  
Hormonal Status ◽  
Social Recognition Memory

scholarly journals Impaired social recognition memory in recombination activating gene 1-deficient mice

2011 ◽  
Vol 1383 ◽  
pp. 187-195 ◽  
Author(s):  
Patrick O. McGowan ◽  
Thomas A. Hope ◽  
Warren H. Meck ◽  
Garnett Kelsoe ◽  
Christina L. Williams
Keyword(s):  
Recognition Memory ◽  
Social Recognition ◽  
Recombination Activating Gene ◽  
Deficient Mice ◽  
Social Recognition Memory

Chronic minocycline treatment improves social recognition memory in adult male Fmr1 knockout mice

2016 ◽  
Vol 312 ◽  
pp. 77-83 ◽  
Author(s):  
Suk Yu Yau ◽  
Christine Chiu ◽  
Mariana Vetrici ◽  
Brian R. Christie
Keyword(s):  
Recognition Memory ◽  
Adult Male ◽  
Knockout Mice ◽  
Social Recognition ◽  
Minocycline Treatment ◽  
Social Recognition Memory

Long-Term Social Recognition Memory Is Mediated by Oxytocin-Dependent Synaptic Plasticity in the Medial Amygdala

2014 ◽  
Vol 76 (5) ◽  
pp. 377-386 ◽  
Author(s):  
Rotem Gur ◽  
Alex Tendler ◽  
Shlomo Wagner
Keyword(s):  
Synaptic Plasticity ◽  
Recognition Memory ◽  
Social Recognition ◽  
Medial Amygdala ◽  
Social Recognition Memory

WAY 267,464, a non-peptide oxytocin receptor agonist, impairs social recognition memory in rats through a vasopressin 1A receptor antagonist action

2015 ◽  
Vol 232 (15) ◽  
pp. 2659-2667 ◽  
Author(s):  
Callum Hicks ◽  
Linnet Ramos ◽  
Tristan A. Reekie ◽  
Rajeshwar Narlawar ◽  
Michael Kassiou ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Oxytocin Receptor ◽  
Social Recognition ◽  
Vasopressin 1A Receptor ◽  
Antagonist Action ◽  
Social Recognition Memory

Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb

Neuroscience ◽  
2008 ◽  
Vol 152 (3) ◽  
pp. 585-593 ◽  
Author(s):  
A. Larrazolo-López ◽  
K.M. Kendrick ◽  
M. Aburto-Arciniega ◽  
V. Arriaga-Ávila ◽  
S. Morimoto ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Olfactory Bulb ◽  
Social Recognition ◽  
Oxytocin Release ◽  
Social Recognition Memory
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