scholarly journals Voltage‐gated calcium channel nanodomains: molecular composition and function

FEBS Journal ◽  
2021 ◽  
Author(s):  
Maria A. Gandini ◽  
Gerald W. Zamponi
Keyword(s):  
Calcium Channel ◽  
Molecular Composition ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
And Function

100 Autoimmune lambert eaton myasthenic syndrome in young adults

2018 ◽  
Vol 89 (6) ◽  
pp. A39.3-A40
Author(s):  
Antony Winkel ◽  
Katrina Reardon ◽  
Leslie Roberts
Keyword(s):  
Neuromuscular Junction ◽  
Calcium Channel ◽  
Lower Limbs ◽  
Response To Treatment ◽  
Whole Body ◽  
Voltage Gated ◽  
Younger Patient ◽  
Myasthenic Syndrome ◽  
Voltage Gated Calcium Channel ◽  
And Function

IntroductionLambert Eaton myasthenic syndrome (LEMS) is a neuromuscular junction transmission disorder that is associated with malignancy (most often small cell lung cancer) and antibodies to the voltage gated calcium channel. Rarely, it can occur as a non-paraneoplastic phenomenon. The diagnosis can be difficult, and reduced motor amplitudes on nerve conduction studies can be misattributed to neurogenic or myopathic processes unless the referring physician or neurophysiologist considers LEMS in the differential diagnosis. Two cases of non-paraneoplastic LEMS were identified from testing performed in the Neurophysiology laboratory of St Vincent’s Hospital Melbourne in 2017. The histories, examination findings, investigations, extensive neurophysiological testing and response to treatment are presented.CasesThe two patients identified were aged 18 and 34 years at diagnosis. Both had a history of slowly progressive proximal weakness preferentially affecting the lower limbs over several years, with associated autonomic symptoms. The younger patient had become wheelchair dependent at age 17. Detailed neurophysiological testing demonstrated a pre-synaptic defect of neuromuscular junction transmission. The younger patient showed myopathic features on needle EMG. Voltage gated calcium channel antibodies were positive in both cases. Treatment with intravenous immunoglobulin, 3, 4-diaminopyridine, pyridostigmine, and azathioprine was associated with a definite improvement in strength and function in both patients. The patient with myopathic EMG features has residual moderate weakness but is now ambulant. Extensive screening for malignancies (including whole-body PET) has been negative, but surveillance will be continued for up to 5 years.ConclusionNon-paraneoplastic LEMS is a rare, but treatable, condition that warrants consideration, particularly when neurophysiological testing reveals reduced motor amplitudes. Successful diagnosis requires a threshold of suspicion in the neurophysiologist or referring neurologist.

scholarly journals Restoration of Motor Defects Caused by Loss of Drosophila TDP-43 by Expression of the Voltage-Gated Calcium Channel, Cacophony, in Central Neurons

2017 ◽  
Vol 37 (39) ◽  
pp. 9486-9497 ◽  
Author(s):  
Kayly M. Lembke ◽  
Charles Scudder ◽  
David B. Morton
Keyword(s):  
Calcium Channel ◽  
Voltage Gated ◽  
Central Neurons ◽  
Voltage Gated Calcium Channel

scholarly journals Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

2019 ◽  
Vol 216 (5) ◽  
pp. 250-253 ◽  
Author(s):  
Paul J. Harrison ◽  
Elizabeth M. Tunbridge ◽  
Annette C. Dolphin ◽  
Jeremy Hall
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Psychiatric Disorders ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Risk Genes ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Voltage Gated Calcium Channel ◽  
Second Use

SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

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