scholarly journals Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

2019 ◽  
Vol 216 (5) ◽  
pp. 250-253 ◽  
Author(s):  
Paul J. Harrison ◽  
Elizabeth M. Tunbridge ◽  
Annette C. Dolphin ◽  
Jeremy Hall
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Psychiatric Disorders ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Risk Genes ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Voltage Gated Calcium Channel ◽  
Second Use

SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

Pre-clinical evaluation of voltage-gated calcium channel blockers derived from the spider P. nigriventer in glioma progression

Toxicon ◽  
2017 ◽  
Vol 129 ◽  
pp. 58-67 ◽  
Author(s):  
Natália Fontana Nicoletti ◽  
Thaís Cristina Erig ◽  
Rafael Fernandes Zanin ◽  
Marcelo Ricardo Roxo ◽  
Nelson Pires Ferreira ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Clinical Evaluation ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Glioma Progression

Modeling ion permeation through a bacterial voltage-gated calcium channel CaVAb using molecular dynamics simulations

2017 ◽  
Vol 13 (1) ◽  
pp. 208-214 ◽  
Author(s):  
Jamal Adiban ◽  
Yousef Jamali ◽  
Hashem Rafii-Tabar
Keyword(s):  
Molecular Dynamics ◽  
Calcium Channels ◽  
Calcium Channel ◽  
Molecular Dynamics Simulations ◽  
Selectivity Filter ◽  
Ion Permeation ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Voltage Gated Calcium Channel ◽  
Dynamics Simulations

Ca2+ion binds tightly to the center of the selectivity filter of voltage-gated calcium channels.

scholarly journals Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers

2016 ◽  
Vol 349 (4) ◽  
pp. 252-267 ◽  
Author(s):  
Lois-May Young ◽  
Werner J. Geldenhuys ◽  
Olwen C. Domingo ◽  
Sarel F. Malan ◽  
Cornelis J. Van der Schyf
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Biological Evaluation ◽  
Channel Blockers ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Synthesis And Biological Evaluation

Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes

2015 ◽  
Vol 68 ◽  
pp. 166-175 ◽  
Author(s):  
Charumathi Pushparaj ◽  
Arindam Das ◽  
Rosa Purroy ◽  
Mireia Nàger ◽  
Judit Herreros ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel
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