Risk Factors for the Development of Post‐Traumatic Headache Attributed to Traumatic Brain Injury: A Systematic Review

Abstract Objectives: In the absence of evidence of acute cerebral herniation, normal ventilation is recommended for patients with traumatic brain injury (TBI). Despite this recommendation, ventilation strategies vary during the initial management of patients with TBI and may impact outcome. The goal of this systematic review was to define the best evidence-based practice of ventilation management during the initial resuscitation period. Methods: A literature search of PubMed, CINAHL, and SCOPUS identified studies from 2009 through 2019 addressing the effects of ventilation during the initial post-trauma resuscitation on patient outcomes. Results: The initial search yielded 899 articles, from which 13 were relevant and selected for full-text review. Six of the 13 articles met the inclusion criteria, all of which reported on patients with TBI. Either end-tidal carbon dioxide (ETCO2) or partial pressure carbon dioxide (PCO2) were the independent variables associated with mortality. Decreased rates of mortality were reported in patients with normal PCO2 or ETCO2. Conclusions: Normoventilation, as measured by ETCO2 or PCO2, is associated with decreased mortality in patients with TBI. Preventing hyperventilation or hypoventilation in patients with TBI during the early resuscitation phase could improve outcome after TBI.

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M-E-058 WHAT DO WE KNOWABOUT PEDIATRIC SLEEP POST TRAUMATIC BRAIN INJURY? A SYSTEMATIC REVIEW OF THE LITERATURE IDENTIFIES GAPS IN RESEARCH AND KNOWLEDGE

Sleep Medicine ◽

10.1016/s1389-9457(11)70136-8 ◽

2011 ◽

Vol 12 ◽

pp. S37-S38

Author(s):

Yair Sadaka ◽

Ryan Hung ◽

Tamsin Adams-Webber ◽

Shelly Weiss

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Review Of The Literature ◽

Post Traumatic ◽

Pediatric Sleep

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Article 8 A Systematic Review of Treatment for Post Traumatic Brain Injury Fatigue

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2012.08.011 ◽

2012 ◽

Vol 93 (10) ◽

pp. e7

Author(s):

Shinakee Gumber ◽

Joshua Cantor ◽

Tessa Hart ◽

Xinsheng Cai ◽

Jianzhou (Tom) Xiao

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Post Traumatic

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Post-Traumatic Headache After Mild Traumatic Brain Injury In A One-Year Follow Up Study – Risk Factors And Return To Work

10.21203/rs.3.rs-1117390/v1 ◽

2021 ◽

Author(s):

Yvonn Kraemer ◽

Kaisa Mäki ◽

Ivan Marinkovic ◽

Taina Nybo ◽

Harri Isokuortti ◽

...

Keyword(s):

Risk Factors ◽

Traumatic Brain Injury ◽

Emergency Department ◽

Brain Injury ◽

Return To Work ◽

Mild Traumatic Brain Injury ◽

Outpatient Clinic ◽

Post Traumatic ◽

One Year

Abstract Background: Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Patients at risk to develop acute PTH (aPTH) and further persistent PTH (pPTH) need to be recognized. Methods: This is a one-year follow-up of 127 patients with mTBI, aged 18 to 68, referred to outpatient clinic in the Helsinki University Hospital. Symptoms were assessed at the emergency department (ED), with structured interview at outpatient clinic visit and with Rivermead post-concussion symptom questionnaire at one, three, and 12 months after injury. Psychiatric disorders were assessed with Structured Clinical Interview for DSM-IV Axis I disorders at 3-4 months and return to work (RTW) from patient records. Results: At one month, 77/127 patients (61%) had aPTH. According to multiple logistic regression analysis, risk factors for aPTH were headache at the emergency department (ED) (OR 5.43), other pain (OR 3.19), insomnia (OR 3.23), and vertigo (OR 5.98). At three months, 17 patients (22% of aPTH patients) had developed pPTH, and at one year, 4 patients (24% of pPTH patients) still presented with pPTH. Risk factors for pPTH at three months were older age (OR 1.06) and current insomnia (OR 12.3). The frequency of psychiatric disorders did not differ between the groups. pPTH patients performed worse on their RTW. Conclusions: Risk factors for aPTH were insomnia, headache at ED, other pain, and vertigo and for pPTH, insomnia and older age. RTW rate was lower among pPTH patients.

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A systematic review of levetiracetam versus phenytoin in the prevention of late post-traumatic seizures and survey of UK neurosurgical prescribing practice of antiepileptic medication in acute traumatic brain injury

British Journal of Neurosurgery ◽

10.1080/02688697.2018.1464118 ◽

2018 ◽

Vol 32 (3) ◽

pp. 237-244 ◽

Cited By ~ 4

Author(s):

Ahmed Bakr ◽

Antonio Belli

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Antiepileptic Medication ◽

Prescribing Practice ◽

Acute Traumatic Brain Injury ◽

Post Traumatic

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Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD) as Risk Factors for Suicidal Thoughts and Behaviors

Suicide: Phenomenology and Neurobiology ◽

10.1007/978-3-319-09964-4_6 ◽

2014 ◽

pp. 101-123 ◽

Cited By ~ 1

Author(s):

Sarra Nazem ◽

Eryn Lonnquist ◽

Lindsey L. Monteith ◽

Lisa A. Brenner

Keyword(s):

Risk Factors ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Stress Disorder ◽

Post Traumatic Stress ◽

Suicidal Thoughts ◽

Post Traumatic ◽

Suicidal Thoughts And Behaviors

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Incidence of post-traumatic hydrocephalus in traumatic brain injury patients that underwent DC versus those that were managed without DC: A systematic review and meta-analysis

Brain and Spine ◽

10.1016/j.bas.2021.100303 ◽

2021 ◽

Vol 1 ◽

pp. 100303

Author(s):

Georgios Mavrovounis ◽

Adamantios Kalogeras ◽

Alexandros Brotis ◽

Corrado Iaccarino ◽

Andreas K. Demetriades ◽

...

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Meta Analysis ◽

Post Traumatic

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Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery

SLEEP ◽

10.1093/sleep/zsaa083 ◽

2020 ◽

Vol 43 (10) ◽

Cited By ~ 1

Author(s):

Madison Luther ◽

Katrina M Poppert Cordts ◽

Cydni N Williams

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Sleep Disturbances ◽

Small Sample Size ◽

Evaluation Studies ◽

Small Sample ◽

Risk Of Bias ◽

Pediatric Tbi

Abstract Study Objectives Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes. Methods Systematic searches were conducted in MEDLINE, PsychINFO, and reference lists for English language articles published from 1999 to 2019 evaluating sleep or fatigue in children hospitalized for mild complicated, moderate, or severe TBI. Two independent reviewers assessed eligibility, extracted data, and assessed risk of bias using the Newcastle–Ottowa Score for observational studies. Results Among 966 articles identified in the search, 126 full-text articles were reviewed, and 24 studies were included (11 prospective, 9 cross-sectional, and 4 case studies). Marked heterogeneity was found in study populations, measures defining SWD, and time from injury to evaluation. Studies showed at least 20% of children with TBI had trouble falling or staying asleep, fatigue, daytime sleepiness, and nightmares. SWD are negatively correlated with posttraumatic cognitive, behavioral, and quality of life outcomes. No comparative intervention studies were identified. The risk of bias was moderate–high for all studies often related to lack of validated or objective SWD measures and small sample size. Heterogeneity precluded meta-analyses. Conclusions SWD are important morbidities after pediatric TBI, though current data are limited. SWD have implications for TBI recovery and may represent a modifiable target for improving outcomes after pediatric TBI.

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