Maspin expression patterns differ in the invasive versus lepidic growth pattern of pulmonary adenocarcinoma

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. ARF occurs 1 in 500 pregnancies and is most common during the postpartum period. Among the specific etiologies that cause ARF during pregnancy that must be considered are: (1) preeclampsia; (2) embolism of amniotic fluid; (3) peripartum cardiomyopathy; and (4) trophoblastic embolism. The case of a 36-year-old patient with a 33-week pregnancy and ARF is presented. The patient presented dyspnea while exerting moderate effort that progressed to orthopnea and type 1 respiratory insufficiency. Imaging studies showed bilateral alveolar infiltrates and predominantly right areas of consolidation. Blood cultures, a galactomannan assay and IgG antibodies against mycoplasma pneumoniae, were reported as negative. Autoimmune etiology was ruled out through an immunoassay. A percutaneous pulmonary biopsy was performed and an invasive pulmonary adenocarcinoma with lepidic growth pattern (i.e. lepidic pulmonary adenocarcinoma, LPA) result was reported. This etiology is rare and very difficult to recognize in acute respiratory failure cases. After infectious, autoimmune and interstitial lung fibrosis have been excluded the clinician must suspect of lung cancer in a patient with acute respiratory failure and chest imaging compatible with the presence of ground-glass nodular opacities, a solitary nodule or mass with bronchogram, and lung consolidation. In the presence of acute respiratory failure, the suspicion of pulmonary neoplasia in an adult of reproductive age must be timely. Failure to recognize this etiology can lead to fatal results.

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Diffuse Pulmonary Adenocarcinoma with Micropapillary Growth Pattern in a Cat

Journal of Comparative Pathology ◽

10.1016/j.jcpa.2018.02.006 ◽

2018 ◽

Vol 160 ◽

pp. 34-38

Author(s):

M. Romanucci ◽

M. Massimini ◽

G. Aste ◽

S.V.P. Defourny ◽

P.E. Crisi ◽

...

Keyword(s):

Growth Pattern ◽

Pulmonary Adenocarcinoma

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Fluorodeoxyglucose Uptake Correlates with the Growth Pattern of Small Peripheral Pulmonary Adenocarcinoma

Surgery Today ◽

10.1007/s00595-005-3123-3 ◽

2006 ◽

Vol 36 (3) ◽

pp. 230-234 ◽

Cited By ~ 12

Author(s):

Motoyasu Sagawa ◽

Kotaro Higashi ◽

Makoto Sugita ◽

Yoshimichi Ueda ◽

Sumiko Maeda ◽

...

Keyword(s):

Growth Pattern ◽

Pulmonary Adenocarcinoma

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Correlation between Thin-Section CT and Histopathological Structure in Pulmonary Adenocarcinoma. 1. Differentiation, Growth Pattern and Interstitial Change.

Haigan ◽

10.2482/haigan.34.199 ◽

1994 ◽

Vol 34 (2) ◽

pp. 199-207

Author(s):

Naoya Koizumi

Keyword(s):

Thin Section ◽

Growth Pattern ◽

Pulmonary Adenocarcinoma

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Morphometry Analysis of Lymphatics in Pulmonary Adenocarcinomas With a Lepidic Growth Pattern

Journal of Histochemistry & Cytochemistry ◽

10.1369/0022155413492538 ◽

2013 ◽

Vol 61 (8) ◽

pp. 571-579

Author(s):

Aurélie Sannier ◽

Marianne Kambouchner ◽

Claire Danel ◽

Patrice Callard ◽

Jean-François Bernaudin

Keyword(s):

Growth Pattern ◽

Morphometry Analysis ◽

Lepidic Growth

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Pseudocarcinomatous Mesothelioma: A Hitherto Unreported Presentation closely simulating primary lung cancer

International Journal of Surgical Pathology ◽

10.1177/1066896921997559 ◽

2021 ◽

pp. 106689692199755

Author(s):

Giulio Rossi ◽

Guido Caroli ◽

Dora Caruso ◽

Franco Stella ◽

Fabio Davoli

Keyword(s):

Lung Cancer ◽

Growth Pattern ◽

Frozen Section ◽

Asbestos Exposure ◽

Primary Lung Cancer ◽

Lung Parenchyma ◽

Positive Staining ◽

Diagnostic Features ◽

Wide Range ◽

Lepidic Growth

Malignant mesothelioma (MM) has a wide range of clinical, radiologic, and pathologic presentations, mimicking lung cancer or interstitial lung diseases when predominantly involving the lung parenchyma. The case herein refers to a 79-year-old man, active smoker without asbestos exposure, incidentally discovered to have a pulmonary nodule in the right upper lobe (1.5 cm). The lesion was misinterpreted as primary lung adenocarcinoma at the frozen section in light of the predominant lepidic growth pattern. Definitive examination confirmed neoplastic proliferation along alveolar structures. However, the unusual globous shape of tumor cells along the alveoli abruptly merging with normal pneumocytes prompted us to perform some immunostains that surprisingly revealed a mesothelial differentiation (positive staining with calretinin, cytokeratins (CK5/6), D2-40, and negativity with BRCA-associated protein 1 (BAP1), Thyroid Transcription Factor 1 [TTF-1], claudin-4, carcinoembryonic antigen [CEA], and napsin). MM represents the pathologic counterpart of so-called pseudomesotheliomatous carcinoma, since it appears as a localized pulmonary neoplastic nodule displaying a predominant lepidic growth pattern (pseudocarcinomatous mesothelioma). The challenging diagnostic features of this unique case and a review of similar cases in the literature are discussed.

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What's behind 68Ga-PSMA-11 Uptake in Primary Prostate Cancer PET? Investigation of Histopathological Parameters and Immunohistochemical PSMA Expression Patterns.

10.21203/rs.3.rs-461507/v1 ◽

2021 ◽

Author(s):

Jan H. Rüschoff ◽

Daniela A. Ferraro ◽

Urs J. Muehlematter ◽

Thomas Hermanns ◽

Ann-Katrin Rodewald ◽

...

Keyword(s):

Prostate Cancer ◽

Growth Pattern ◽

Primary Tumour ◽

Expression Patterns ◽

Pet Scan ◽

Grade Group ◽

Psma Pet ◽

Infiltrative Growth Pattern ◽

Group 2 ◽

Psma Expression

Abstract Purpose: Prostate specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific primary tumour features might impact accuracy of PSMA-PET for PCa detection. We investigated histopathological parameters and immunohistochemical PSMA expression patterns on radical prostatectomy (RPE) specimens and correlated them to the corresponding 68Ga-PSMA-11-PET examinations.Methods: RPE specimen of 62 patients with preoperative 68Ga-PSMA-11-PET between 2016 and 2018 were analyzed. WHO/ISUP grade groups, growth pattern (expansive vs. infiltrative), tumour area and diameter as well as immunhistochemical PSMA heterogeneity, intensity and negative tumour area (PSMA%neg) were correlated with spatially corresponding SUVmax on 68Ga-PSMA-11-PET in a multidisciplinary analysis.Results: All tumours showed medium to strong membranous (2-3+) and weak to strong cytoplasmic (1-3+) PSMA expression. Heterogeneously expressed PSMA was found in 38 cases (61%). Twenty-five cases (40%) showed at least 5% and up to 80% PSMA%neg. PSMA%neg, infiltrative growth pattern, smaller tumour area and diameter and WHO/ISUP grade group 2 significantly correlated with lower SUVmax values. A ROC curve analysis revealed 20% PSMA%neg as an optimal cutoff with the highest sensitivity and specificity (89% and 86%, AUC 0.923) for a negative PSMA-PET scan. A multiple logistic regression model revealed tumoural PSMA%neg (p<0.01, OR=9.629) and growth pattern (p=0.0497, OR=306.537) as significant predictors for a negative PSMA-PET scan.Conclusions: We describe PSMA%neg, infiltrative growth pattern, smaller tumour size and WHO/ISUP grade group 2 as parameters associated with a lower 68Ga-PSMA-11 uptake in prostate cancer. These findings can serve as fundament for future biopsy-based biomarker development to enable an individualized, tumour-adapted imaging approach.

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Distinct Expression Patterns of E-Cadherin and β-Catenin in Signet Ring Cell Carcinoma Components of Primary Pulmonary Adenocarcinoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2006-130-1320-depoea ◽

2006 ◽

Vol 130 (9) ◽

pp. 1320-1325

Author(s):

Kyung Chul Moon ◽

Soo Youn Cho ◽

Hye Seung Lee ◽

Yoon Kyung Jeon ◽

Jin-Haeng Chung ◽

...

Keyword(s):

Cell Carcinoma ◽

Expression Patterns ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Pulmonary Adenocarcinoma ◽

Cancer Development ◽

Nuclear Accumulation ◽

Signet Ring ◽

Ring Cell ◽

E Cadherin

Abstract Context.—E-Cadherin and β-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and β-catenin expressions of this tumor have not been documented, to our knowledge. Objective.—To characterize the E-cadherin and β-catenin expressions in SRCC of the lung. Design.—An immunohistochemical evaluation of E-cadherin and β-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. Results.—Membranous E-cadherin and β-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear β-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear β-catenin accumulation (0/10). Conclusions.—Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or β-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and β-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs.

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