Prognostic value of progesterone receptor expression in tubo-ovarian high-grade serous carcinoma of the COEUR cohort

2019 ◽  
Vol 74 (4) ◽  
pp. 663-666 ◽  
Author(s):  
Cécile Le Page ◽  
Kurosh Rahimi ◽  
Anne-Marie Mes-Masson ◽  
Martin Köbel
Keyword(s):  
Progesterone Receptor ◽  
Prognostic Value ◽  
Receptor Expression ◽  
Serous Carcinoma ◽  
High Grade ◽  
Progesterone Receptor Expression

scholarly journals Prognostic value of progesterone receptor expression in ovarian cancer: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (22) ◽  
pp. 36845-36856 ◽  
Author(s):  
Hui Luo ◽  
Saisai Li ◽  
Menghuang Zhao ◽  
Bo Sheng ◽  
Haiyan Zhu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Progesterone Receptor ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Receptor Expression ◽  
Progesterone Receptor Expression

scholarly journals Evaluation of progesterone receptor expression in low- and high-grade astrocytomas

2021 ◽  
Vol 67 (7) ◽  
pp. 975-978
Author(s):  
Cléciton Braga Tavares ◽  
Francisca das Chagas Sheyla Almeida Gomes Braga ◽  
Emerson Brandão Sousa ◽  
Heloisa Aurora Cavalcante Soares de Melo ◽  
José Nazareno Pearce de Oliveira Brito
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
High Grade ◽  
Progesterone Receptor Expression

Progesterone receptor expression is associated with longer overall survival within high-grade histotypes of endometrial carcinoma: A Canadian high risk endometrial cancer consortium (CHREC) study

2016 ◽  
Vol 141 (3) ◽  
pp. 559-563 ◽  
Author(s):  
Martin Köbel ◽  
Eshetu G. Atenafu ◽  
Peter F. Rambau ◽  
Sarah E. Ferguson ◽  
Gregg S. Nelson ◽  
...  
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
High Risk ◽  
Progesterone Receptor ◽  
Endometrial Carcinoma ◽  
Receptor Expression ◽  
High Grade ◽  
Progesterone Receptor Expression

scholarly journals Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues

2010 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Georgios Kararigas ◽  
Eva Becher ◽  
Shokoufeh Mahmoodzadeh ◽  
Christoph Knosalla ◽  
Roland Hetzer ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
Progesterone Receptor Expression ◽  
Cardiac Tissues ◽  
Specific Modification

Interaction Between Progesterone and Interleukin-1β in Modulating Progesterone Receptor Expression and the Inflammatory Phenotype in Human Cervical Fibroblasts

2017 ◽  
Vol 25 (4) ◽  
pp. 598-608 ◽  
Author(s):  
Stephanie Pierce ◽  
Amy E. Roberson ◽  
Kimberly Hyatt ◽  
Krista Singleton ◽  
David Deschamps ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
Interleukin 1Β ◽  
Progesterone Receptor Expression ◽  
Inflammatory Phenotype

scholarly journals Her-2/neu, Estrogen And Progesterone Receptor Expression In Who Grade I Meningiomas

2009 ◽  
Author(s):  
Nilufer Onak Kandemir ◽  
Aylin Ege Gul ◽  
Banu Dogan Gun ◽  
Nimet Karadayi ◽  
Gamze Yurdakan ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
Progesterone Receptor Expression ◽  
Who Grade ◽  
Her 2 ◽  
Estrogen And Progesterone Receptor

scholarly journals Highly Expressed Progesterone Receptor B Isoform Increases Platinum Sensitivity and Survival of Ovarian High-Grade Serous Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5578
Author(s):  
Hao Lin ◽  
Kuo-Chung Lan ◽  
Yu-Che Ou ◽  
Chen-Hsuan Wu ◽  
Hong-Yo Kang ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Cell Model ◽  
Serous Carcinoma ◽  
Survival Outcomes ◽  
High Grade ◽  
Cancer Specific Survival ◽  
Platinum Sensitivity ◽  
Platinum Sensitive ◽  
Resistant Disease ◽  
Cisplatin Sensitivity

Background: Expression of the progesterone receptor (PR) has been reported to influence survival outcomes in patients with ovarian high-grade serous carcinoma (HGSC). In the present study, we attempted to investigate the association among PR and its isoforms’ expression, platinum sensitivity, and survival in ovarian HGSC. Material and methods: This retrospective study reviewed ovarian HGSC patients who received surgery followed by adjuvant chemotherapy. We analyzed total PR and PR isoform-B (PR-B) expression by immunohistochemical staining and quantified using the H-score. Then, we compared platinum sensitivity and survival outcomes between those patients with weak and strong PR-B expression. Cisplatin viability assays were carried out in ovarian HGSC cell lines (OC-3-VGH and OVCAR-3) with different PR-B expression. Results: Among 90 patients, 49 and 41 patients were considered to have platinum-sensitive and platinum-resistant disease, respectively. Pearson’s correlation model showed that the H-score of total PR correlated positively with PR-B (r = 0.813). The PR-B H-score of tumors was significantly higher in the platinum-sensitive group (p = 0.004). Multivariate analysis revealed that the PR-B H-score and optimal debulking status were independent factors predicting platinum sensitivity. When compared with strong PR-B expression, patients with weak PR-B had significantly poorer progression-free (p = 0.021) and cancer-specific survival (p = 0.046). In a cell model, cisplatin-resistant OC-3-VGH cells expressed a lower level of PR-B than wild-type cells. Overexpression of PR-B or progesterone could increase cisplatin sensitivity in both OC-3-VGH and OVCAR-3 cells via the mechanism of promoting cisplatin-related apoptosis. Conclusions: When compared to weak PR-B, ovarian HGSC patients with a strong PR-B expression had a better chance of platinum sensitivity and survival, and this finding was compatible with our experimental results. Progesterone seemed to be a platinum sensitizer, but the value of adding progesterone in the treatment of ovarian HGSC should be further investigated.

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