Clinicopathological evaluation of the programmed cell death 1 (PD1)/programmed cell death‐ligand 1 (PD‐L1) axis in post‐transplant lymphoproliferative disorders: association with Epstein–Barr virus,PD‐L1copy number alterations, and outcome

2019 ◽  
Vol 75 (6) ◽  
pp. 799-812 ◽  
Author(s):  
Luis Veloza ◽  
Cristina Teixido ◽  
Natalia Castrejon ◽  
Fina Climent ◽  
Ana Carrió ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Post Transplant ◽  
Barr Virus ◽  
Programmed Cell Death 1 ◽  
Epstein Barr

scholarly journals Human Herpesvirus and the Immune Checkpoint PD-1/PD-L1 Pathway: Disorders and Strategies for Survival

2021 ◽  
Vol 9 (4) ◽  
pp. 778
Author(s):  
Takayuki Murata
Keyword(s):  
Cell Death ◽  
Immune System ◽  
Programmed Cell Death ◽  
Immune Checkpoint ◽  
Human Herpesvirus ◽  
Barr Virus ◽  
Programmed Cell Death 1 ◽  
Epstein Barr ◽  
Simplex Virus ◽  
Human Herpesviruses

The immune system has evolved as a complex and efficient means of coping with extrinsic materials, such as pathogens and toxins, as well as intrinsic abnormalities, such as cancers. Although rapid and timely activation of the immune system is obviously important, regulated downregulation of the system is almost as significant as activation to prevent runaway immunity, such as allergies and hypercytokinemia. Therefore, the immune checkpoint programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is beneficial for the host. On the other hand, pathogens have evolved to evade host immunity by taking advantage of the PD-1/PD-L1 pathway. This review is focused on human herpesviruses, such as herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein–Barr virus (EBV), which cause various types of disorders, and their relationships with the PD-1/PD-L1 pathway. Understanding such relationships will be useful for developing preventative and therapeutic methods for disorders caused by herpesviruses.

scholarly journals Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study

2019 ◽  
Vol Volume 11 ◽  
pp. 7605-7618 ◽  
Author(s):  
Ewelina Grywalska ◽  
Marcin Pasiarski ◽  
Barbara Sosnowska-Pasiarska ◽  
Paweł Macek ◽  
Agnieszka Rolińska ◽  
...  
Keyword(s):  
Cell Death ◽  
Cohort Study ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Lymphocytic Leukaemia ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Programmed Cell Death 1 ◽  
Epstein Barr ◽  
Barr Virus Infection
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