e21550 Background:Cancers are the second most common cause of death. Treatment of cancers is complex and might be aggressive, takes a long time and is usually difficult to accept for patients. As a result of disease and treatment a body image(BI) is impaired and can reduce quality of life(QoL),which has become a very important factor. The objective of the study was to investigate BI and QoL during oncological treatment of breast cancer(BCa), cervical cancer(CeCa) and prostate cancer(PCa) patients and to compare with healthy groups of men(HM) and women(HW). Methods:The analysis included 280 participants: 31 BCa-pts just after oncological surgery (age26-86 years,M = 63,23,Me = 65), 44 BCa-pts during adjuvant radiotherapy (age37-69years, M = 57,23,Me = 60), 21 CeCa-pts during therapy (age30-68years,M = 54,43,Me = 60), 52 PCa-pts with clinical stage T1-T2N0M0 (age57-86;M = 70,65;Me = 70) after standard three-dimensional conformal radiation treatment (3DCRT), 32 PCa-pts (age59-84;M = 74;Me = 75) after stereotactic hypofractionated radiotherapy (HRT), than without any type of cancer 50HM (age47-92years;M = 62,28;Me = 60) and 50HW (age30-84 years,M = 51,46,Me = 50). The subjects filled out the questionnaire EORTC QLQ-C30 (ver3.0.) and a specially designed questionnaire for a body image assessment. Results:All factors associated with BI between groups differed significantly (p < 0,05): general appearance, self-esteem, physical and sexual attractiveness. The highest assessment in all categories were done by HRT-pts and the lowest by BCa-pts during radiotherapy, than BCa-pts after surgery. HM and HW perceived BI on a similar level, however lower than HRT-pts. Overall QoL was significantly lowest in BCa-pts after surgery (p < 0,05), but physical, role, emotional, and general functioning were the worst in BCa-pts during radiotherapy (p < 0,05). The lowest social QoL was assessed by CeCa-pts (p < 0,05). Conclusions:It seems that oncological treatment influences significantly BI of cancer patients and worsens QoL especially in breast cancer women just after surgery and adjuvant radiotherapy. HTR-pts assesses BI and general QoL even better than healthy groups.