Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata

2017 ◽  
Vol 27 (2) ◽  
pp. 177-187 ◽  
Author(s):  
G. Neelakanta ◽  
H. Sultana ◽  
D. E. Sonenshine ◽  
J. F. Andersen
Keyword(s):  
Relapsing Fever ◽  
Histamine Binding ◽  
Identification And Characterization

scholarly journals Identification and Characterization of a Linear-Plasmid-Encoded Factor H-Binding Protein (FhbA) of the Relapsing Fever Spirochete Borrelia hermsii

2004 ◽  
Vol 186 (9) ◽  
pp. 2612-2618 ◽  
Author(s):  
Kelley M. Hovis ◽  
John V. McDowell ◽  
LaToya Griffin ◽  
Richard T. Marconi
Keyword(s):  
Molecular Mechanisms ◽  
Binding Protein ◽  
Genetic Locus ◽  
Factor H ◽  
Linear Plasmid ◽  
Relapsing Fever ◽  
Gene Encoding ◽  
Borrelia Hermsii ◽  
Identification And Characterization

ABSTRACT In North America, tick-borne relapsing fever (TBRF) is caused by the spirochete species Borrelia hermsii, Borrelia parkeri, and Borrelia turicatae. We previously demonstrated that some isolates of B. hermsii and B. parkeri are capable of binding factor H and that cell-bound factor H can participate in the factor I-mediated cleavage of C3b. Isolates that bound factor H expressed a factor H-binding protein (FHBP) that we estimated to be approximately 19 to 20 kDa in size and thus, pending further characterization, temporarily designated FHBP19. Until this report, none of the FHBPs of the TBRF spirochetes had been characterized. Here we have recovered the gene encoding the FHBP of B. hermsii YOR from a lambda ZAP II library and determined its sequence. The gene encodes a full-length protein of 22.7 kDa, which after processing is predicted to be 20.5 kDa. This protein, which we redesignate factor H-binding protein A (FhbA), is unique to B. hermsii. Two-dimensional pulsed-field gel electrophoresis and hybridization analyses revealed that the B. hermsii gene encoding FhbA is a single genetic locus that maps to a linear plasmid of approximately 220 kb. The general properties of FhbA were also assessed. The protein was found to be surface exposed and lipidated. Analysis of the antibody response to FhbA in infected mice revealed that it is antigenic during infection, indicating expression during infection. The identification and characterization of FhbA provides further insight into the molecular mechanisms of pathogenesis of the relapsing fever spirochetes.

Identification and characterization of peptidases secreted by quahog parasite unknown (QPX), the protistan parasite of hard clams

2016 ◽  
Vol 122 (1) ◽  
pp. 21-33 ◽  
Author(s):  
E Rubin ◽  
GT Werneburg ◽  
E Pales Espinosa ◽  
DG Thanassi ◽  
B Allam
Keyword(s):  
Quahog Parasite Unknown ◽  
Hard Clams ◽  
Identification And Characterization

Identification and characterization of Vibrio harveyi associated with diseased abalone Haliotis diversicolor

2013 ◽  
Vol 103 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Q Jiang ◽  
L Shi ◽  
C Ke ◽  
W You ◽  
J Zhao
Keyword(s):  
Vibrio Harveyi ◽  
Haliotis Diversicolor ◽  
Identification And Characterization

IDENTIFICATION AND CHARACTERIZATION OF 1,2-BN CYCLOHEXENE USING MICROWAVE SPECTROSCOPY

2016 ◽  
Author(s):  
Stephen Kukolich ◽  
Shih-Yuan Liu ◽  
Jacob Ishibashi ◽  
Adam Daly ◽  
Ming Sun
Keyword(s):  
Microwave Spectroscopy ◽  
Identification And Characterization

Identification and characterization of a CRM1/XPO1-dependent nuclear export signal in the human androgen receptor

2016 ◽  
Author(s):  
Stefanie V Schutz ◽  
Axel Merseburger ◽  
Anca Azoitei ◽  
Marcus V Cronauer
Keyword(s):  
Androgen Receptor ◽  
Nuclear Export ◽  
Nuclear Export Signal ◽  
Export Signal ◽  
Identification And Characterization ◽  
Human Androgen Receptor

Clinical evaluation and genetic analysis of patients affected by premature ovarian insufficiency: Identification and characterization of a new mutation of the BMP-15

2020 ◽  
Author(s):  
Francesca Orsolini ◽  
Eleonora Ferrarini ◽  
Patrizia Agretti ◽  
Marco Giuseppina De ◽  
Cosmo Caterina Di ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Clinical Evaluation ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
New Mutation ◽  
Identification And Characterization

Identification and characterization of aldose reductase in cultured rat mesangial cells

Diabetes ◽  
1992 ◽  
Vol 41 (9) ◽  
pp. 1165-1171 ◽  
Author(s):  
R. Kikkawa ◽  
K. Umemura ◽  
M. Haneda ◽  
N. Kajiwara ◽  
S. Maeda ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Mesangial Cells ◽  
Identification And Characterization
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