Stability and change in epigenetic regulation of immune cells

James Scott‐Browne; Han‐Yu Shih

doi:10.1111/imr.13060

Stability and change in epigenetic regulation of immune cells

Immunological Reviews ◽

10.1111/imr.13060 ◽

2022 ◽

Vol 305 (1) ◽

pp. 5-8

Author(s):

James Scott‐Browne ◽

Han‐Yu Shih

Keyword(s):

Epigenetic Regulation ◽

Immune Cells ◽

Stability And Change

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Epigenetic Regulation of Cancer Immune Cells

Seminars in Cancer Biology ◽

10.1016/j.semcancer.2021.06.022 ◽

2021 ◽

Author(s):

Diego A. Patino ◽

Vijay Radhakrishnan ◽

Kanve N. Suvilesh ◽

Yariswamy Manjunath ◽

Guangfu Li ◽

...

Keyword(s):

Epigenetic Regulation ◽

Immune Cells

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Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

International Journal of Molecular Sciences ◽

10.3390/ijms222212170 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12170

Author(s):

Melissa Payet ◽

Farouk Dargai ◽

Philippe Gasque ◽

Xavier Guillot

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Dna Methylation ◽

Histone Modifications ◽

Epigenetic Regulation ◽

Inflammatory Reaction ◽

Murine Model ◽

Immune Cells ◽

Arthritis Score ◽

Micro Rnas

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.

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