scholarly journals Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

2021 ◽  
Vol 22 (22) ◽  
pp. 12170
Author(s):  
Melissa Payet ◽  
Farouk Dargai ◽  
Philippe Gasque ◽  
Xavier Guillot
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Dna Methylation ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Inflammatory Reaction ◽  
Murine Model ◽  
Immune Cells ◽  
Arthritis Score ◽  
Micro Rnas

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.

scholarly journals Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells

Oncogene ◽  
2007 ◽  
Vol 26 (45) ◽  
pp. 6566-6576 ◽  
Author(s):  
A Vincent ◽  
M Perrais ◽  
J-L Desseyn ◽  
J-P Aubert ◽  
P Pigny ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Epithelial Cancer ◽  
Mucin Genes

scholarly journals The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

2020 ◽  
Vol 21 (17) ◽  
pp. 6217
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Bradley Eric Aouizerat ◽  
Iya Ghassib ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Periodontal Disease ◽  
Histone Modification ◽  
Histone Modifications ◽  
Disease Risk ◽  
Periodontal Diseases ◽  
Epigenetic Changes ◽  
Human Adults

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. IL6, IL6R, IFNG, PTGS2, SOCS1, and TNF were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

scholarly journals The role of DNA methylation and histone modifications in blood pressure: a systematic review

2019 ◽  
Vol 33 (10) ◽  
pp. 703-715 ◽  
Author(s):  
Valentina Gonzalez-Jaramillo ◽  
Eliana Portilla-Fernandez ◽  
Marija Glisic ◽  
Trudy Voortman ◽  
Wichor Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Dna Methylation ◽  
Histone Modifications

scholarly journals Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update

2021 ◽  
Vol 14 (6) ◽  
pp. 491
Author(s):  
Pía Loren ◽  
Nicolás Saavedra ◽  
Kathleen Saavedra ◽  
Tomás Zambrano ◽  
Patricia Moriel ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cell Death ◽  
Side Effects ◽  
Signaling Pathways ◽  
Solid Tumors ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Epigenetic Mechanisms ◽  
Non Coding Rnas ◽  
New Strategies

Cisplatin is an antineoplastic drug used for the treatment of many solid tumors. Among its various side effects, nephrotoxicity is the most detrimental. In recent years, epigenetic regulation has emerged as a modulatory mechanism of cisplatin-induced nephrotoxicity, involving non-coding RNAs, DNA methylation and histone modifications. These epigenetic marks alter different signaling pathways leading to damage and cell death. In this review, we describe how different epigenetic modifications alter different pathways leading to cell death by apoptosis, autophagy, necroptosis, among others. The study of epigenetic regulation is still under development, and much research remains to fully determine the epigenetic mechanisms underlying cell death, which will allow leading new strategies for the diagnosis and therapy of this disease.

scholarly journals Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance

Epigenomes ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 18 ◽  
Author(s):  
You-Yuan Pang ◽  
Rita Jui-Hsien Lu ◽  
Pao-Yang Chen
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Animal Behavior ◽  
Noncoding Rna ◽  
Environmental Enrichment ◽  
Epigenetic Inheritance ◽  
Epigenetic Alterations ◽  
Molecular Processes ◽  
Regulate Gene Expression

Epigenetic regulation plays an important role in gene regulation, and epigenetic markers such as DNA methylation and histone modifications are generally described as switches that regulate gene expression. Behavioral epigenetics is defined as the study of how epigenetic alterations induced by experience and environmental stress may affect animal behavior. It studies epigenetic alterations due to environmental enrichment. Generally, molecular processes underlying epigenetic regulation in behavioral epigenetics include DNA methylation, post-translational histone modifications, noncoding RNA activity, and other unknown molecular processes. Whether the inheritance of epigenetic features will occur is a crucial question. In general, the mechanism underlying inheritance can be explained by two main phenomena: Germline-mediated epigenetic inheritance and interact epigenetic inheritance of somatic cells through germline. In this review, we focus on examining behavioral epigenetics based on its possible modes of inheritance and discuss the considerations in the research of epigenetic transgenerational inheritance.

scholarly journals MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1137
Author(s):  
Amélia Favier ◽  
Grégoire Rocher ◽  
Annette K. Larsen ◽  
Romain Delangle ◽  
Catherine Uzan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Endometrial Cancer ◽  
Epigenetic Regulation ◽  
Target Genes ◽  
Current Knowledge ◽  
Surrounding Tissue ◽  
Expression Levels ◽  
Meta Analyses

The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRNAs in the epigenetic regulation of EC applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: microRNA, miRNA, miR, endometrial cancer, endometrium, epigenetic, epimutation, hypermethylation, lynch, deacetylase, DICER, novel biomarker, histone, chromatin. The miRNAs were classified and are presented according to their function (tumor suppressor or onco-miRNA), their targets (when known), their expression levels in EC tissue vs the normal surrounding tissue, and the degree of DNA methylation in miRNA loci and CpG sites. Data were collected from 201 articles, including 190 original articles, published between November 1, 2008 and September 30, 2020 identifying 313 different miRNAs implicated in epigenetic regulation of EC. Overall, we identified a total of 148 miRNAs with decreased expression in EC, 140 miRNAs with increased expression in EC, and 22 miRNAs with discordant expression levels. The literature implicated different epigenetic phenomena including altered miRNA expression levels (miR-182, -230), changes in the methylation of miRNA loci (miR-34b, -129-2, -130a/b, -152, -200b, -625) and increased/decreased methylation of target genes (miR-30d,-191). This work provides an overview of all miRNAs reported to be involved in epigenetic regulation in EC including DNA methylation and RNA-associated silencing. These findings may contribute to novel strategies in diagnosis, risk assessment, and treatments aimed at miRNAs, their target genes or DNA methylation.

scholarly journals Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer

2016 ◽  
Vol 242 (2) ◽  
pp. 140-147 ◽  
Author(s):  
Suet-Hui Ow ◽  
Pei-Jou Chua ◽  
Boon-Huat Bay
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Histone Deacetylases ◽  
Epigenetic Mechanisms ◽  
Epigenetic Regulators ◽  
Future Treatments ◽  
Peroxiredoxin I ◽  
Reversible Nature

Peroxiredoxin I to VI (PRX I–VI), a family of highly conserved antioxidants, has been implicated in numerous diseases. There have been reports that PRXs are expressed aberrantly in a variety of tumors, implying that they could play an important role in carcinogenesis. Epigenetic mechanisms such as DNA methylation, histone modifications, and microRNAs have been reported to modulate expression of PRXs. In addition, the use of epigenetic regulators, such as histone deacetylases, has been demonstrated to restore PRX to normal levels, indicating that the reversible nature of epigenetics can be exploited for future treatments.

scholarly journals Effects of Wutou Decoction on DNA Methylation and Histone Modifications in Rats with Collagen-Induced Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Ya-Fei Liu ◽  
Cai-Yu-Zhu Wen ◽  
Zhe Chen ◽  
Yu Wang ◽  
Ying Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Methylation ◽  
Histone Modifications ◽  
Dna Methyltransferase ◽  
Mononuclear Cells ◽  
Dna Methyltransferase 1 ◽  
Collagen Induced Arthritis ◽  
Peripheral Blood Mononuclear ◽  
Hematoxylin And Eosin ◽  
H3 Acetylation

Background. Wutou decoction (WTD) has been wildly applied in the treatment of rheumatoid arthritis and experimental arthritis in rats for many years. Epigenetic deregulation is associated with the aetiology of rheumatoid arthritis; however, the effects of WTD on epigenetic changes are unclear. This study is set to explore the effects of WTD on DNA methylation and histone modifications in rats with collagen-induced arthritis (CIA).Methods. The CIA model was established by the stimulation of collagen and adjuvant. The knee synovium was stained with hematoxylin and eosin. The DNA methyltransferase 1 (DNMT1) and methylated CpG binding domain 2 (MBD2) expression of peripheral blood mononuclear cells (PBMCs) were determined by Real-Time PCR. The global DNA histone H3-K4/H3-K27 methylation and total histones H3 and H4 acetylation of PBMCs were detected.Results. Our data demonstrated that the DNMT1 mRNA expression was significantly lowered in group WTD compared to that in group CIA (P<0.05). The DNA methylation level was significantly reduced in group WTD compared to that in group CIA (P<0.05). Moreover, H3 acetylation of PBMCs was overexpressed in WTD compared with CIA (P<0.05).Conclusions. WTD may modulate DNA methylation and histone modifications, functioning as anti-inflammatory potential.

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