scholarly journals Expression of somatostatin mRNA and peptides in C-cell tumours of the thyroid gland in Han Wistar rats

2004 ◽  
Vol 85 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Andrew Pilling ◽  
Stewart Jones ◽  
John Turton
Keyword(s):  
Thyroid Gland ◽  
Wistar Rats ◽  
C Cell

scholarly journals Hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions

2010 ◽  
Vol 138 (5-6) ◽  
pp. 323-327 ◽  
Author(s):  
Ljiljana Markovic ◽  
Violeta Mihailovic-Vucinic ◽  
Jelena Aritonovic
Keyword(s):  
Thyroid Gland ◽  
Genetic Susceptibility ◽  
Experimental Model ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Cell Necrosis ◽  
High Iodine ◽  
Hormone Status ◽  
Potassium Iodine ◽  
Iodine Dose

Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Objective The purpose of this study was to compare the effects of low and high doses of KI on the thyroid gland of Wistar rats and determine the effect on hormone status (T4, T3 and TSH) in this rat strain. Methods Two groups of rats from the Wistar strain were treated with a low iodine dose (225 ?g/g BW) and with a high iodine dose (675 ?g/g BW) of KI solutions. Untreated nonimmunized animals served as controls. The solution was administrated daily intraperitoneally during the period of 26 consecutive days. Results Monitoring hormone status (TSH, T3 and T4) and morphological changes it was found that therapeutic doses of KI applied in treatment induced the occurrence of experimental thyroiditis (chronic destructive Hashimoto's thyroiditis in humans) and cell necrosis in animals not carrying a genetic susceptibility. Significant inflammatory changes were observed in rats treated with a high iodine dose. Conclusion The early iodine induced cell necrosis and inflammation in the nonimmunized animals without genetic susceptibility is a new experimental model of thyroiditis. .

EFFECT OF HYPOTHYROIDISM ON THE HEPARIN-STIMULATED RELEASE OF LIPASE FROM THE ISOLATED PERFUSED RAT LIVER

1978 ◽  
Vol 76 (2) ◽  
pp. 369-370 ◽  
Author(s):  
J. JUBELIN ◽  
G. LAM VAN ◽  
J. BOYER
Keyword(s):  
Adipose Tissue ◽  
Thyroid Gland ◽  
Wistar Rats ◽  
Hepatic Lipase ◽  
Human Subjects ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Lipoprotein Lipase Activity ◽  
Lipolytic Enzymes ◽  
Male Wistar Rats

Service d'Explorations Métaboliques, Hôpital de la Conception, 13385 Marseille Cedex 4, France (Received 24 August 1977) Indirect observations, derived from the assay of lipase in the blood from human subjects after administration of heparin, have suggested that diseases of the thyroid gland are associated with alterations in the activity of lipolytic enzymes (Porte, O'Hara & Williams, 1966; Kirkeby, 1968; Nikkilä & Kekki, 1972; Tulloch, Lewis & Russel-Fraser, 1973; Jubelin, Bettendorf & Boyer, 1974; Krause, Levy & Fredrikson, 1974). Lipoprotein lipase activity has been measured in adipose tissue from hypothyroid subjects and was found to be normal or raised in rats (Shafrir & Biale, 1971) and reduced in men (Pykälistö, Goldberg & Brunzell, 1976). This work was undertaken to assess alterations in the activity of hepatic lipase during hypothyroidism. Male Wistar rats (200–220 g) were thyroidectomized and injected (i.p.) 15 days later with 100 μ 131I. A period of 1 month

Quantitative changes in the frequency and distribution of the C-cell population in the rat thyroid gland with age

1992 ◽  
Vol 270 (1) ◽  
pp. 73-77 ◽  
Author(s):  
I. Mart�n-Lacave ◽  
E. Conde ◽  
C. Montero ◽  
H. Galera-Davidson
Keyword(s):  
Thyroid Gland ◽  
Cell Population ◽  
C Cell ◽  
Quantitative Changes ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

C-cell Distribution in Ovine Thyroid Gland

1995 ◽  
Vol 24 (4) ◽  
pp. 281-284 ◽  
Author(s):  
H. Okada ◽  
Y. Shigeta ◽  
Y. Un-No
Keyword(s):  
Thyroid Gland ◽  
Cell Distribution ◽  
C Cell

PATHOGENESIS OF C-CELL NEOPLASIA IN THYROID GLAND

2009 ◽  
Vol 80A (5) ◽  
pp. 577-588
Author(s):  
Otto Ljungberg ◽  
John-Fredrik Dymling
Keyword(s):  
Thyroid Gland ◽  
C Cell

Influence of Peloid Therapy on the Condition and Functional Activity of the Glands of Internal Secretion in Juvenile Rheumatoid Arthritis (Clinical and Experimental Study)

2020 ◽  
Vol 98 (4) ◽  
pp. 82-89
Author(s):  
N.N. Kaladze ◽  
E.Y. Zyablitskaya
Keyword(s):  
Rheumatoid Arthritis ◽  
Thyroid Gland ◽  
Juvenile Rheumatoid Arthritis ◽  
Functional Activity ◽  
Adjuvant Arthritis ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Thyroid Axis ◽  
Peloid Therapy ◽  
Positive Effect

The aim of the study was to assess the dynamics of hormones of the pituitary-gonadal-thyroid axis in patients with juvenile rheumatoid arthritis under the influence of peloid therapy and to establish the corresponding morphological changes in the pituitary gland, gonads and the thyroid gland of white Wistar rats with induced adjuvant arthritis during peloid therapy. Material and methods. 46 patients with juvenile rheumatoid arthritis were examined during their rehabilitation at sanatoria. The effect of peloid therapy on the pituitary-gonadal-thyroid axis was evaluated based on the changes in the levels of the main hormones LH, FSH, estradiol, testosterone, TSH, T3, T4. The control group consisted of 15 healthy age-mates. Morphological changes in the pituitary, testes, ovaries and thyroid gland were studied in 24 white Wistar rats with adjuvant arthritis. Results. In juvenile rheumatoid arthritis, the pituitary-gonad-thyroid axis is activated, which is manifested by a decrease in the production of FSH, LH, TSH, testosterone in boys of all age groups and estradiol both in girls regardless of their age and in boys 12–17 years of age. At the same time, an increase in secretion of T3, T4 was observed. The most pronounced deviations were noted in patients with a systemic form of the disease, with a high degree of severity and duration of the disease. The inclusion of mud therapy into the program of sanatorium rehabilitation leads to positive changes in the levels of the studied hormones. The experiment with induced adjuvant arthritis revealed reversible ultrastructural and tinctorial changes in the thyrotropocytes and gonadotropocytes of the pituitary gland, as well as impaired differentiation and partial destruction of the structural elements in the thyroid gland and gonads. The course of peloid therapy had a positive effect on the condition of the thyroid gland and gonads in the experimental animals, which was manifested by the restoration of structural and functional organization. Conclusion. Peloid therapy has a positive effect on the functional activity of the pituitary-gonadal thyroid axis in patients with juvenile rheumatoid arthritis, which has been confirmed by experimental data.

The C-cell-tumors of the thyroid gland in childhood

1983 ◽  
Vol 18 (1) ◽  
pp. 104
Author(s):  
Thomas A. Angerpointner
Keyword(s):  
Thyroid Gland ◽  
C Cell
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