In this article, we described specific features of baby skin and care for it (washing baby's face, bottom; cleaning ears, nose, and eyes; baby's bathing). We also assessed the efficacy of cream-balm ‘Tamba-PS’ (‘Adonis’ LLC, Russia) for the treatment of atopic dermatitis. ‘Tamba-PS’ contains only natural ingredients, including oil extract of native peloids from Lake Tambukan, plant extracts and essential oils, propolis, mumiyo, beeswax, honey, olive oil, sea buckthorn oil, coconut oil, and lecithin. We demonstrated its efficacy in infants and children aged 3 months to 3 years with both focal skin lesions and advanced lesions. Treatment improved children's quality of life, which was evaluated using the Dermatology Life Quality Index (DLQI) for children (from 22.8 ± 3.1 to 10.1 ± 2.0, р < 0.01); ‘socialization’ (according to the ‘KID-questionnaire,’ p ≤ 0.05) and the dynamics of clinical manifestations according to the SCORAD index (from 33.1 ± 2.9 to 14.2 ± 1.8 after therapy, p < 0.01). The unique composition of ‘Tamba-PS’ allows its daily use for problematic, irritated skin of children, as well as to protect normal skin from adverse effects, and as the external therapy for atopic dermatitis (the minimum course is 2 weeks (twice a day); the courses can be repeated if necessary). Key words: atopic dermatitis, Lake Tambukan mud, peloid therapy, skin care