scholarly journals Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine

2002 ◽  
Vol 93 (10) ◽  
pp. 1076-1082 ◽  
Author(s):  
Shoji Fukushima ◽  
Hideki Wanibuchi ◽  
Keiichirou Morimura ◽  
Min Wei ◽  
Dai Nakae ◽  
...  
Keyword(s):  
Rat Liver ◽  
Dose Response ◽  
Low Doses ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Investigations on the dose–response relationship of combined exposure to low doses of three anti-androgens in Wistar rats

2017 ◽  
Vol 91 (12) ◽  
pp. 3961-3989 ◽  
Author(s):  
Steffen Schneider ◽  
Karma C. Fussell ◽  
Stephanie Melching-Kollmuss ◽  
Roland Buesen ◽  
Sibylle Gröters ◽  
...  
Keyword(s):  
Dose Response ◽  
Wistar Rats ◽  
Low Doses ◽  
Response Relationship ◽  
Combined Exposure ◽  
Dose Response Relationship ◽  
Relationship Of

Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver

1986 ◽  
Vol 32 (3) ◽  
pp. 305-311 ◽  
Author(s):  
Michael A. Pereira ◽  
Sydna L. Herren-Freund ◽  
Richard E. Long
Keyword(s):  
Rat Liver ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Relationship Of

No Dose Response Relationship for Heart Disease at Low Doses

2011 ◽  
Vol 81 (2) ◽  
pp. S64 ◽  
Author(s):  
E. Chung ◽  
J.R. Corbett ◽  
J.M. Moran ◽  
K.A. Griffith ◽  
R.B. Marsh ◽  
...  
Keyword(s):  
Heart Disease ◽  
Dose Response ◽  
Low Doses ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

2021 ◽  
Author(s):  
Evgenios Agathokleous ◽  
Damià Barceló ◽  
Despo Fatta-Kassinos ◽  
Michael N. Moore ◽  
Edward J. Calabrese
Keyword(s):  
Dose Response ◽  
Aquatic Organisms ◽  
Risk Assessments ◽  
Contaminants Of Emerging Concern ◽  
Low Doses ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
High Doses ◽  
Living Organisms ◽  
Biphasic Dose Response

Contaminants of emerging concern are widespread in the world’s waters, raising concerns regarding their effects on living organisms. To evaluate the effects of and predict risks associated with such chemicals, dose-response studies are needed, while the nature of the dose-response relationship is critical for the outcomes of such evaluations. Here, we summarize the literature reporting hormetic responses of aquatic organisms to contaminants of emerging concern. Hormesis is a biphasic dose response encompassing stimulatory responses to low doses and inhibitory responses to high doses. We demonstrate that it occurs widely in numerous aquatic organisms exposed to a wide array of contaminants, including nano/microplastics, suggesting potential effects at doses/concentrations that are considerably lower than the traditional toxicological threshold, which cannot be identified or predicted unless hormesis is considered in the study design. To tackle the effects and associated risks of nano/microplastics and other contaminants on aquatic organisms, hormesis should therefore be taken into account early in the design of studies as well as in relevant risk assessments.

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