Transformation of C3H 10T1/2 cells by low doses of ionising radiation: a collaborative study by six European laboratories strongly supporting a linear dose-response relationship

1998 ◽  
Vol 18 (2) ◽  
pp. 79-100 ◽  
Author(s):  
A J Mill ◽  
D Frankenberg ◽  
D Bettega ◽  
L Hieber ◽  
A Saran ◽  
...  
Keyword(s):  
Dose Response ◽  
Collaborative Study ◽  
Ionising Radiation ◽  
Low Doses ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Linear Dose

scholarly journals Investigations on the dose–response relationship of combined exposure to low doses of three anti-androgens in Wistar rats

2017 ◽  
Vol 91 (12) ◽  
pp. 3961-3989 ◽  
Author(s):  
Steffen Schneider ◽  
Karma C. Fussell ◽  
Stephanie Melching-Kollmuss ◽  
Roland Buesen ◽  
Sibylle Gröters ◽  
...  
Keyword(s):  
Dose Response ◽  
Wistar Rats ◽  
Low Doses ◽  
Response Relationship ◽  
Combined Exposure ◽  
Dose Response Relationship ◽  
Relationship Of

scholarly journals Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan-Hong Wei ◽  
Qi-Qi Mao
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Vitamin B12 ◽  
Dose Response ◽  
Vitamin B6 ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Pancreatic Cancer Risk ◽  
Linear Dose

Abstract Background Nutrients involved in one-carbon metabolism may play a key role in pancreatic carcinogenesis. The aim of this study was to examine the association between pancreatic cancer risk and intake or blood levels of vitamins B6, B12 and methionine via meta-analysis. Methods A systematic search was performed in PubMed, Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI) up to April 2020 to identify relevant studies. Risk estimates and their 95% confidence intervals (CIs) were retrieved from the studies and combined by a random-effect model. Results A total of 18 studies were included in this meta-analysis on the association of vitamin B6, B12 and methionine with pancreatic cancer risk. The combined risk estimate (95% CI) of pancreatic cancer for the highest vs lowest category of vitamin B6 intake and blood pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels was 0.63 (0.48–0.79) and 0.65 (0.52–0.79), respectively. The results indicated a non-linear dose-response relationship between vitamin B6 intake and pancreatic risk. Linear dose–response relationship was found, and the risk of pancreatic cancer decreased by 9% for every 10 nmol/L increment in blood PLP levels. No significant association were found between pancreatic cancer risk and vitamin B12 intake, blood vitamin B12 levels, methionine intake and blood methionine levels. Conclusion Our study suggests that high intake of vitamin B6 and high concentration of blood PLP levels may be protective against the development of pancreatic cancer. Further research are warranted to confirm the results.

No Dose Response Relationship for Heart Disease at Low Doses

2011 ◽  
Vol 81 (2) ◽  
pp. S64 ◽  
Author(s):  
E. Chung ◽  
J.R. Corbett ◽  
J.M. Moran ◽  
K.A. Griffith ◽  
R.B. Marsh ◽  
...  
Keyword(s):  
Heart Disease ◽  
Dose Response ◽  
Low Doses ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

2015 ◽  
Vol 19 (8) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nai-Hui Sun ◽  
Xuan-Zhang Huang ◽  
Shuai-Bo Wang ◽  
Yuan Li ◽  
Long-Yi Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Total Vitamin ◽  
Linear Dose ◽  
Non Linear

AbstractObjectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.DesignThe PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.SettingThe meta-analysis included seventeen studies.SubjectsA total of 10 601 patients.ResultsThe non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).ConclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

Collaborative Study of the Chicken Embryo Bioassay for Aflatoxin B1

1973 ◽  
Vol 56 (4) ◽  
pp. 901-904
Author(s):  
M Jacqueline Verrett ◽  
James Winbush ◽  
Edilberto F Reynaldo ◽  
William F Scott
Keyword(s):  
Aflatoxin B1 ◽  
Chicken Embryo ◽  
Peanut Butter ◽  
Collaborative Study ◽  
Standard Errors ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Unknown Quantity ◽  
Linear Dose ◽  
Good Agreement

Abstract A collaborative study of the bioassay for the detection of aflatoxin B1, 26.057–26.061, was undertaken with 9 laboratories participating. The study was designed to evaluate the toxicity of an aflatoxin B1 standard, and an unknown quantity of aflatoxin B1 extracted from peanut butter. The baseline was provided by an assay of an extract of an aflatoxin-free peanut butter and by the appropriate solvent and untreated control eggs. The data were analyzed for linearity of response and agreement of the LD-50’s and slopes. In general, a linear dose-response relationship was exhibited, and there was good agreement of the slopes and LD-50’s and their associated standard errors. The method has been adopted as official first action.

The Thermoluminescence Response of Dy Doped Calcium Borate Glass Subjected to 6MV Photon Irradiation

2014 ◽  
Vol 895 ◽  
pp. 390-394 ◽  
Author(s):  
Hamiza Ahmad Tajuddin ◽  
Husin Wagiran ◽  
Rosli Hussin
Keyword(s):  
Dose Response ◽  
Borate Glass ◽  
Glass Sample ◽  
Dopant Concentration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Melt Quenching ◽  
Photon Irradiation ◽  
Linear Dose ◽  
Quenching Method

This paper presents the thermoluminescence (TL) response and sensitivity of various dopant concentration of Dy into borate glass. Borates glass present absorption coefficient that closely to human bone and teeth. This fact makes borate as an ideal material for TL material either for medical or environmental dosimeter. Therefore, a series of glasses based on xCaO-(100-x)B2O3system (0 x 100) % weight has been prepared by using melt quenching method. In this research, Dy doped (0.01-0.4) mol% to 30CaO-70B2O3glass sample were studied to investigate the TL properties in terms of dose-response relationship and sensitivity. Samples were irradiated to various doses range 0.5-4.0 Gy subjected to 6 MV photon irradiation by using LINAC Primus MLC 3339. The TL intensity of various dopant concentration were studied and it was founds that the 0.3 mol% Dy has the highest TL response and has linear dose response relationship. The highest sensitivity was calculated as 58 nC.mg-1.Gy-1for 0.3 mol% Dy concentration.

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