Does misoprostol given as a single large dose improve its antisecretory effect?

2007 ◽  
Vol 3 (4) ◽  
pp. 403-407 ◽  
Author(s):  
S. G. CHIVERTON ◽  
D. W. BURGET ◽  
B. J. SALENA ◽  
R. H. HUNT
Keyword(s):  
Large Dose ◽  
Antisecretory Effect ◽  
Single Large Dose

Dothiepin for depression: single nightly dosage

1977 ◽  
Vol 15 (23) ◽  
pp. 92-92
Keyword(s):  
Single Dose ◽  
Depressed Patient ◽  
Large Dose ◽  
Half Life ◽  
Dosage Regimen ◽  
The Body ◽  
Dry Mouth ◽  
Blurred Vision ◽  
Depressed Patients ◽  
Single Large Dose

Depressed patients tend to be forgetful, and for them a simple dosage regimen is particularly appropriate. The use of a single daily dosage depends on the drug having a relatively long (over 36 hours) half-life in the body and being tolerated in a single large dose. Many tricyclic anti-depressives fulfil these requirements provided that the single dose is given before the patient goes to bed. Unwanted effects such as dry mouth and blurred vision, which are troublesome during the day, are not a problem during sleep. The sedative actions of many of these drugs can help the insomniac depressed patient who might otherwise need a separate hypnotic.

Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats

2011 ◽  
Vol 14 (11) ◽  
pp. 627-633 ◽  
Author(s):  
Mahmoud Kandeel ◽  
Iman Abdelaziz ◽  
Nagwan Elhabashy ◽  
Hanaa Hegazy ◽  
Yasmin Tolba
Keyword(s):  
Oxidative Stress ◽  
Large Dose ◽  
And Oxidative Stress ◽  
Single Large Dose

scholarly journals Pharmacokinetics of a single, large dose of cholecalciferol

2008 ◽  
Vol 87 (3) ◽  
pp. 688-691 ◽  
Author(s):  
Marium Ilahi ◽  
Laura AG Armas ◽  
Robert P Heaney
Keyword(s):  
Large Dose ◽  
Single Large Dose

Effect of a single large dose local x-rays on allogeneic skin graft rejection in the mouse

1970 ◽  
Vol 10 (6) ◽  
pp. 271-275 ◽  
Author(s):  
J.A. McCredie ◽  
W.R. Inch ◽  
R.M. Sutherland ◽  
J. Vanderkooy
Keyword(s):  
Skin Graft ◽  
Large Dose ◽  
Graft Rejection ◽  
X Rays ◽  
Single Large Dose
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