Clinical trial: the effects of a probiotic mixture on non-steroidal anti-inflammatory drug enteropathy - a randomized, double-blind, cross-over, placebo-controlled study

In a double-blind, randomized trial on thirty-two patients affected by classical or definite rheumatoid arthritis, we have tried the effectiveness and safety of 500 mg/day oral diftalone versus 75 mg/day oral indomethacin for a period of six to twelve months treatment. Diftalone proved to be an effective and well tolerated anti-inflammatory drug in long-term treatment of rheumatoid arthritis. Its activity and safety is at least comparable to that achieved by the use of indomethacin.

Download Full-text

The effects on a gastroduodenal mucosa of a new anti-inflammatory drug, amtolmetin-guacyl, versus piroxicam, in healthy volunteers. a short term, double blind, endoscopic controlled, study

Gastroenterology ◽

10.1016/s0016-5085(00)80902-6 ◽

2000 ◽

Vol 118 (4) ◽

pp. A1264

Author(s):

Marco Lazzaroni ◽

Andrea Anderloni ◽

Gabriele Bianchi Porro

Keyword(s):

Healthy Volunteers ◽

Controlled Study ◽

Short Term ◽

Double Blind ◽

Inflammatory Drug ◽

Gastroduodenal Mucosa ◽

Anti Inflammatory

Download Full-text

Effect of preoperative oral administration of steroids in comparison to an anti‐inflammatory drug on postoperative pain following single‐visit root canal treatment – a double‐blind, randomized clinical trial

International Endodontic Journal ◽

10.1111/iej.13416 ◽

2020 ◽

Author(s):

N. Suresh ◽

V. Nagendrababu ◽

V. Koteeswaran ◽

J. S. Haritha ◽

S. D. Swetha ◽

...

Keyword(s):

Clinical Trial ◽

Postoperative Pain ◽

Oral Administration ◽

Randomized Clinical Trial ◽

Root Canal ◽

Root Canal Treatment ◽

Double Blind ◽

Inflammatory Drug ◽

Single Visit ◽

Anti Inflammatory

Download Full-text

Primary Prevention by Omeprazole 20 mg Daily of the Adverse Gastrointestinal Effects of Short-Term Non-Steroidal Anti-Inflammatory Drug Use in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Study

The American Journal of Gastroenterology ◽

10.14309/00000434-200709002-00146 ◽

2007 ◽

Vol 102 ◽

pp. S170

Author(s):

Jay C. Desai ◽

Shefali M. Sanyal ◽

Tyralee Goo ◽

Ariel A. Benson ◽

Carol A. Bodian ◽

...

Keyword(s):

Primary Prevention ◽

Drug Use ◽

Healthy Subjects ◽

Controlled Study ◽

Short Term ◽

Double Blind ◽

Double Blind Placebo ◽

Inflammatory Drug ◽

Anti Inflammatory

Download Full-text

Evaluation of the Antibacterial efficacy of newly formulated Nano Triple Antibiotic paste with Nano Anti-inflammatory drug as a root canal medicament. (A double blind randomized clinical trial)

Egyptian Dental Journal ◽

10.21608/edj.2020.41856.1245 ◽

2020 ◽

Vol 66 (4) ◽

pp. 2815-2824

Author(s):

yousra Nashaat

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Root Canal ◽

Antibacterial Efficacy ◽

Double Blind ◽

Inflammatory Drug ◽

Triple Antibiotic Paste ◽

Anti Inflammatory

Download Full-text

968 A Randomized Double-Blind Crossover Placebo-Controlled Study to Investigate the Effect of Nonsteroidal Anti-Inflammatory Drug on Acid-Induced Esophageal Sensation in Healthy Volunteers

Gastroenterology ◽

10.1016/s0016-5085(13)60626-5 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-176

Author(s):

Takashi Kondo ◽

Tadayuki Oshima ◽

Toshihiko Tomita ◽

Hirokazu Fukui ◽

Jiro Watari ◽

...

Keyword(s):

Healthy Volunteers ◽

Controlled Study ◽

Double Blind ◽

Inflammatory Drug ◽

Anti Inflammatory

Download Full-text

The effects on gastroduodenal mucosa of a new nonsteroidal anti-inflammatory drug, amtolmetin-guacyl, versus piroxicam in healthy volunteers: a short-term, double-blind, endoscopically controlled study

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-200107000-00012 ◽

2001 ◽

Vol 13 (7) ◽

pp. 833-839 ◽

Cited By ~ 7

Author(s):

M. Lazzaroni ◽

A. Anderloni ◽

G. Bianchi Porro

Keyword(s):

Healthy Volunteers ◽

Controlled Study ◽

Short Term ◽

Double Blind ◽

Inflammatory Drug ◽

Gastroduodenal Mucosa ◽

Anti Inflammatory

Download Full-text

General Practitioners' Evaluation of Side-Effects and Efficacy of Oxamethacin as Compared with Indomethacin

Journal of International Medical Research ◽

10.1177/030006058000800211 ◽

1980 ◽

Vol 8 (2) ◽

pp. 156-162 ◽

Cited By ~ 6

Author(s):

J Polderman ◽

M Colon

Keyword(s):

Clinical Trial ◽

Drug Therapy ◽

Side Effects ◽

General Practitioners ◽

Double Blind ◽

Inflammatory Drug ◽

Pathological Conditions ◽

Maximum Duration ◽

Double Blind Clinical Trial ◽

Anti Inflammatory

Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/250 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p < 10−2); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p<5.10−2). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p < 5.10−5). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p < 2.10−3).

Download Full-text