Validation of Sickness Impact Profile and Psoriasis Disability Index in psoriasis

1990 ◽  
Vol 123 (6) ◽  
pp. 751-756 ◽  
Author(s):  
A.Y. FINLAY ◽  
G.K. KHAN ◽  
D.K. LUSCOMBE ◽  
M.S. SALEK
Keyword(s):  
Sickness Impact Profile ◽  
Psoriasis Disability Index

ISA247: Quality of Life Results from a Phase II, Randomized, Placebo-Controlled Study

2008 ◽  
Vol 12 (6) ◽  
pp. 268-275 ◽  
Author(s):  
Aditya K. Gupta ◽  
Richard G. Langley ◽  
Charles Lynde ◽  
Kirk Barber ◽  
Wayne Gulliver ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Phase Ii ◽  
Life Quality ◽  
Skin Condition ◽  
Controlled Study ◽  
Double Blind ◽  
Plaque Type ◽  
Psoriasis Disability Index ◽  
Stable Plaque

Background: Psoriasis is a chronic skin condition that can negatively affect a patient's quality of life (QoL), often hindering social functioning. ISA247, a novel psoriatic agent, has shown clinical efficacy in moderate to severe psoriasis sufferers, but its effect on QoL is currently not reported. Objective: The objective of this study was to assess the effect of ISA247 on the QoL in patients with stable, plaque-type psoriasis. Methods: A phase II, randomized, double-blind, placebo-controlled, parallel-group, multicenter study assessed the effects of ISA247 doses of 0.5 mg/kg/d ( n = 77) or 1.5 mg/kg/d ( n = 83) compared with placebo ( n = 41) for 12 weeks. QoL was assessed using the Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI) scales. Results: ISA247 treatment (pooled groups) significantly improved QoL scores as assessed by both the DLQI and the PDI compared with those receiving placebo ( p < .05). Treatment with the higher dose of 1.5 mg/kg/d demonstrated a significantly greater response to many of the QoL scales compared with the 0.5 mg/kg/d group ( p < .05). Conclusions: ISA247 appears to improve the QoL while also providing effective treatment for chronic, moderate to severe, plaque-type psoriasis.

Disequilibrium in patients with atherosclerosis

Neurology ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 570-573 ◽  
Author(s):  
Vincent I.H. Kwa ◽  
Laura H. Zaal ◽  
Bernard Verbeeten ◽  
Jan Stam ◽  
Keyword(s):  
Sickness Impact Profile ◽  
Statistical Significance ◽  
Structured Interview ◽  
The Body ◽  
Pontine Nuclei ◽  
Mri Findings ◽  
Initial Manifestation ◽  
Walking Test ◽  
Walking Tests ◽  
Body Care

Objective: To examine the clinical relevance of isolated pontine hyperintense lesions(PHLs) on MRI in patients with atherosclerosis.Methods: Seventeen atherosclerotic patients with isolated PHL on MRI were compared with 17 patients without PHL and were matched for age, sex, and initial manifestation of atherosclerosis. Subjects and observer were blinded to the MRI findings. We assessed symptoms, impairment, and disability with a structured interview and neurologic examination as well as disability scales.Results: On all items, patients with PHL scored worse that did their controls. We found the largest differences in frequencies of symptoms of disequilibrium, difficulties with speech or swallowing, the Timed Walking Test, and the body care and movement subscale of the Sickness Impact Profile. Except for disequilibrium (p = 0.04), these differences did not reach statistical significance. Abnormal tandem-walking tests were more frequent in patients than they were in controls. Pyramidal signs were equally distributed.Conclusions: We propose PHL as a cause of symptoms of disequilibrium in patients with atherosclerosis. Symptoms are probably elicited by dysfunction of the corticopontine fibers, the pontocerebellar fibers, or the pontine nuclei.

Su1689 Eight Questions of the Patient-Reported Sickness Impact Profile Can Effectively Screen for Minimal Hepatic Encephalopathy

2013 ◽  
Vol 144 (5) ◽  
pp. S-998
Author(s):  
Eiman H. Nabi ◽  
Leroy R. Thacker ◽  
Douglas M. Heuman ◽  
Arun J. Sanyal ◽  
Richard K. Sterling ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Sickness Impact Profile ◽  
Minimal Hepatic Encephalopathy ◽  
Patient Reported

Scaling the sickness impact profile using item response theory: an exploration of linearity, adaptive use, and patient driven item weights

2004 ◽  
Vol 57 (1) ◽  
pp. 66-74 ◽  
Author(s):  
R. Lindeboom ◽  
R. Holman, Mmath ◽  
M.G.W. Dijkgraaf ◽  
M.A.G. Sprangers ◽  
E. Buskens ◽  
...  
Keyword(s):  
Item Response Theory ◽  
Item Response ◽  
Sickness Impact Profile ◽  
Response Theory ◽  
Adaptive Use

scholarly journals Assessment of the reliability of the Serbian version of the sickness impact profile questionnaire in patients with chronic viral hepatitis

2015 ◽  
Vol 143 (11-12) ◽  
pp. 688-694
Author(s):  
Biljana Majstorovic ◽  
Slobodan Jankovic ◽  
Zvonko Dimoski ◽  
Divna Kekus ◽  
Sanja Kocic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Factor Analysis ◽  
Chronic Hepatitis ◽  
Sickness Impact Profile ◽  
Chronic Viral Hepatitis ◽  
English Version ◽  
Alpha Coefficient ◽  
Serbian Version ◽  
Psychosocial Dimension

Introduction. Health-related quality of life (HRQL) of chronic patients has been researched as the ultimate goal of modern treatment of chronic diseases to improve patients? quality of life. Objective. The objective was to assess the reliability of the Serbian version of the Sickness Impact Profile (SIP) questionnaire on the sample of patients with chronic viral hepatitis. Methods. The research covered 102 patients with chronic hepatitis (47 type B and 55 type C). The assessment of the reliability of the SIP questionnaire was performed by testing the internal consistency of the questions by calculating the Cronbach?s alpha coefficient. The factor analysis was used to assess whether the grouping of the questions within dimensions matches the distribution of the questions in the original English version of the questionnaire administered to U.S. patient population. Results. The Cronbach?s alpha coefficient for the entire questionnaire is 0.925, 0.869 for the physical dimension, and 0.857 for the psychosocial dimension. After running a factor analysis of the psychosocial dimension, ?emotional instability? was extracted as the key factor, confirming the results of previous research. Compared with the English version of the questionnaire, the Cronbach?s alpha coefficient of the Serbian version does not diverge significantly, whereas the factor analysis confirms the classification of the questionnaire into two dimensions. Conclusion. Our study has shown that the Serbian version of the SIP questionnaire is a reliable tool for assessing the HRQL of patients with chronic hepatitis B and C before starting treatment.

Treatment of Poststroke Pain by Epidural Motor Cortex Stimulation With a New Octopolar Lead

2011 ◽  
Vol 68 (suppl_1) ◽  
pp. ons180-ons187 ◽  
Author(s):  
Jean-Pascal Lefaucheur ◽  
Yves Keravel ◽  
Jean-Paul Nguyen
Keyword(s):  
Motor Cortex ◽  
Rating Scale ◽  
Sickness Impact Profile ◽  
Brief Pain Inventory ◽  
Mcgill Pain Questionnaire ◽  
Motor Cortex Stimulation ◽  
Pain Questionnaire ◽  
Affective Component ◽  
Clinical Scores

Abstract BACKGROUND: Chronic, drug-resistant neuropathic pain can be treated by surgically implanted motor cortex stimulation (MCS). The leads used for MCS have not been specifically designed for this application. OBJECTIVE: To study the value of a new 8-contact lead for MCS therapy in a series of 6 patients with refractory central poststroke pain. METHODS: The study comprised a 1-month randomized phase, starting 1 month after implantation, during which the neurostimulator was switched on in one-half of the patients or remained off in the other half, followed by an open phase of 10 months, during which the stimulator was switched on in all patients. Clinical assessment was performed at baseline and 1, 2, 3, 6, and 12 months after implantation with the following scales: Visual Analog Scale, Verbal Rating Scale, Brief Pain Inventory, McGill Pain Questionnaire, Sickness Impact Profile, and Medication Quantification Scale. RESULTS: In the randomized phase, clinical scores were found to be globally reduced in the on- vs off-stimulation condition. In the open follow-up phase, all clinical scores improved significantly over time. The ratio between affective and sensory McGill Pain Questionnaire subscores decreased, suggesting a preferential effect of MCS on the affective component of pain. Compared with preoperative baseline, 2 patients were totally relieved of central poststroke pain, 3 patients were very much relieved, and 1 patient remained unchanged at the final examination. CONCLUSION: A good clinical outcome was observed in all patients except 1, suggesting that this new octopolar lead could be used for MCS therapy to treat refractory central poststroke pain.

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