The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage

2007 ◽  
Vol 139 (3) ◽  
pp. 385-397 ◽  
Author(s):  
Rentian Feng ◽  
Ana Oton ◽  
Markus Y. Mapara ◽  
Gülsüm Anderson ◽  
Chandra Belani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Dna Damage ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

Expression of Leukemia-Associated Fusion Proteins Increases Sensitivity to Histone Deacetylase Inhibitor–Induced DNA Damage and Apoptosis

2013 ◽  
Vol 12 (8) ◽  
pp. 1591-1604 ◽  
Author(s):  
Luca A. Petruccelli ◽  
Filippa Pettersson ◽  
Sonia V. del Rincón ◽  
Cynthia Guilbert ◽  
Jonathan D. Licht ◽  
...  
Keyword(s):  
Dna Damage ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Fusion Proteins ◽  
Deacetylase Inhibitor

scholarly journals Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Science ◽  
2012 ◽  
Vol 339 (6116) ◽  
pp. 211-214 ◽  
Author(s):  
T. Shimazu ◽  
M. D. Hirschey ◽  
J. Newman ◽  
W. He ◽  
K. Shirakawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

scholarly journals Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma

Cancer ◽  
2010 ◽  
Vol 117 (2) ◽  
pp. 336-342 ◽  
Author(s):  
Ruben Niesvizky ◽  
Scott Ely ◽  
Tomer Mark ◽  
Sangeeta Aggarwal ◽  
Janice L Gabrilove ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Phase 2 ◽  
Refractory Multiple Myeloma ◽  
Phase 2 Trial ◽  
Deacetylase Inhibitor
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