WT1expression levels at diagnosis could predict long-term time-to-progression in adult patients affected by acute myeloid leukaemia and myelodysplastic syndromes

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

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Impact of pre-transplant serum ferritin on outcomes of patients with myelodysplastic syndromes or secondary acute myeloid leukaemia receiving reduced intensity conditioning allogeneic haematopoietic stem cell transplantation

Leukemia Research ◽

10.1016/j.leukres.2009.10.028 ◽

2010 ◽

Vol 34 (6) ◽

pp. 723-727 ◽

Cited By ~ 59

Author(s):

Z.Y. Lim ◽

V. Fiaccadori ◽

S. Gandhi ◽

J. Hayden ◽

M. Kenyon ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Myelodysplastic Syndromes ◽

Haematopoietic Stem Cell Transplantation ◽

Haematopoietic Stem Cell ◽

Reduced Intensity Conditioning ◽

Reduced Intensity ◽

Acute Myeloid

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World Health Organization Sub-Types, Initial Treatment Outcome and Prognostic Study of Unselected Adult Patients with Acute Myeloid Leukaemia in Shanghai: An Analysis of 623 Cases

Journal of International Medical Research ◽

10.1177/147323000903700426 ◽

2009 ◽

Vol 37 (4) ◽

pp. 1191-1201 ◽

Cited By ~ 4

Author(s):

Y Ma ◽

X Wang ◽

X Xu ◽

G Lin

Keyword(s):

Prognostic Factor ◽

Acute Myeloid Leukaemia ◽

World Health Organization ◽

Myeloid Leukaemia ◽

Treatment Effect ◽

Developed Countries ◽

World Health ◽

Health Organization ◽

Acute Myeloid

This study investigated the complete remission (CR) rate and survival of 623 newly diagnosed patients with acute myeloid leukaemia (AML) in Shanghai, China, classified according to World Health Organization and French–American–British criteria, and compared the differences in treatment effect with those reported in developed countries and those reported in Shanghai from 1984 to 1994. Total CR rate was 66.5%, median survival was 18 months and estimated survival at 3 years was 30.8%. The 3-year relapse rate was 55.1%. These data showed that the CR rate was similar to that achieved in studies from developed countries, but long-term survival was worse. The CR rate and survival were increased markedly compared with data previously collected in Shanghai (1984-1994). Induction chemotherapeutic regimens based on idarubicin, daunorubicin or homoharringtonine all had similar CR rates and survivals. Karyotype was the most important prognostic factor. Multilineage dysplasia in de novo AML was not an independent prognostic factor. Improvement in the long-term treatment effect in China is an important challenge for the future.

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