The effect of haemopoietic stem cell proliferation on the humoral immune response in mice

1987 ◽  
Vol 20 (5) ◽  
pp. 485-491
Author(s):  
V. A. Kozlov ◽  
I. A. Orlovskaya ◽  
I. G. Tsyrlova
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Humoral Immune Response ◽  
Stem Cell Proliferation ◽  
Humoral Immune ◽  
Haemopoietic Stem Cell

Effect of stem cell proliferation inhibiting factor on development of the immune response to viral antigen

1992 ◽  
Vol 113 (3) ◽  
pp. 383-385
Author(s):  
I. A. Orlovskaya ◽  
A. N. Evstropov ◽  
L. N. Gritsenko ◽  
L. V. Dubinina ◽  
I. G. Tsyrlova ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Viral Antigen ◽  
Stem Cell Proliferation ◽  
Inhibiting Factor

scholarly journals Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis

1988 ◽  
Vol 256 (2) ◽  
pp. 585-592 ◽  
Author(s):  
A D Whetton ◽  
S J Vallance ◽  
P N Monk ◽  
E J Cragoe ◽  
T M Dexter ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Intracellular Ph ◽  
Stem Cell Proliferation ◽  
Interleukin 3 ◽  
Haemopoietic Stem Cell ◽  
Kinase C

Interleukin 3 (IL-3) is an important regulator of haemopoietic stem cell proliferation both in vivo and in vitro. Little is known about the possible mechanisms whereby this growth factor acts on stem cells to stimulate cell survival and proliferation. Here we have investigated the role of intracellular pH and the Na+/H+ antiport in stem cell proliferation using the multipotential IL-3-dependent stem cell line, FDCP-Mix 1. Evidence is presented that IL-3 can stimulate the activation of an amiloride-sensitive Na+/H+ exchange via protein kinase C activation. IL-3-mediated activation of the Na+/H+ exchange is not observed in FDCP-Mix 1 cells where protein kinase C levels have been down-modulated by treatment with phorbol esters. Also the protein kinase C inhibitor H7 can inhibit IL-3-mediated increases in intracellular pH. This activation of Na+/H+ exchange via protein kinase C has been shown to occur with no measurable effects of IL-3 on inositol lipid hydrolysis or on cytosolic Ca2+ levels. Evidence is also presented that this IL-3-stimulated alkalinization acts as a signal for cellular proliferation in stem cells.

Actions of the haemopoietic stem cell proliferation inhibitor

1979 ◽  
Vol 28 (12) ◽  
pp. 1843-1848 ◽  
Author(s):  
Brian I. Lord ◽  
Eric G. Wright ◽  
Laszlo G. Lajtha
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Stem Cell Proliferation ◽  
Haemopoietic Stem Cell
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