Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria

2012 ◽  
Vol 42 (12) ◽  
pp. 1772-1781 ◽  
Author(s):  
J. A. Cornejo-García ◽  
L. R. Jagemann ◽  
N. Blanca-López ◽  
I. Doña ◽  
C. Flores ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Genetic Variants ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Acute Urticaria ◽  
Anti Inflammatory ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease

2015 ◽  
Vol 16 (8) ◽  
pp. 825-839 ◽  
Author(s):  
Pedro Ayuso ◽  
María del Carmen Plaza-Serón ◽  
Natalia Blanca-López ◽  
Inmaculada Doña ◽  
Paloma Campo ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Respiratory Disease ◽  
Genetic Variants ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

scholarly journals The protective effects of 18β-glycyrrhetinic acid against inflammation microenvironment in gastric tumorigenesis targeting PGE2-EP2 receptor-mediated arachidonic acid pathway

2018 ◽  
Vol 16 ◽  
pp. 205873921876299 ◽  
Author(s):  
Donghui Cao ◽  
Jing Jiang ◽  
Dan Zhao ◽  
Menghui Wu ◽  
Houjun Zhang ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Glycyrrhetinic Acid ◽  
Prostaglandin E ◽  
Protective Effects ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Acid Pathway ◽  
Ep2 Receptor ◽  
Arachidonic Acid Pathway

Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for gastrointestinal diseases. Glycyrrhiza glabra, a traditional Chinese medicine, has been shown to safely suppress gastric cancer; however, the anti-inflammatory mechanisms in gastric tumorigenesis have been poorly investigated. Therefore, this study is committed to demonstrate the in vivo anti-inflammatory effect of 18β-glycyrrhetinic acid (GRA), the main active component of G. glabra. The lymphocytes and macrophages were heavily infiltrated in the transgenic mice that highly expressed cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1; however, a significant reduction was observed after treatment with GRA. In addition, GRA downregulated the protein levels of COX-2, GαS, EP2, and β-catenin, which were involved in the arachidonic acid pathway. In conclusion, our study showed the potential protective effects of GRA against inflammatory environment that might be involved in gastric tumorigenesis in vivo through the PGE2-EP2 receptor-mediated arachidonic acid pathway.

scholarly journals Genetic Variants of Thymic Stromal Lymphopoietin in Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema

2016 ◽  
Vol 169 (4) ◽  
pp. 249-255 ◽  
Author(s):  
María del Carmen Plaza-Serón ◽  
Natalia Blanca-López ◽  
Natalia Pérez-Sánchez ◽  
Inmaculada Doña ◽  
Marialbert Acosta-Herrera ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Thymic Stromal Lymphopoietin ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

Inflammation ◽  
2015 ◽  
Vol 38 (4) ◽  
pp. 1639-1648 ◽  
Author(s):  
Chunfeng Xie ◽  
Xiaoting Li ◽  
Jieshu Wu ◽  
Zhaofeng Liang ◽  
Feifei Deng ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway ◽  
Magnesium Isoglycyrrhizinate
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