scholarly journals Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease

2006 ◽  
Vol 145 (3) ◽  
pp. 474-479 ◽  
Author(s):  
B. Barcelo ◽  
J. Pons ◽  
A. Fuster ◽  
J. Sauleda ◽  
A. Noguera ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Lymphocytes ◽  
Pulmonary Disease ◽  
Cytokine Profile ◽  
Chronic Obstructive ◽  
Intracellular Cytokine ◽  
Obstructive Pulmonary Disease

scholarly journals Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease

2017 ◽  
Vol 44 (1) ◽  
pp. 11-16
Author(s):  
V. Dielievska ◽  
P. Kravchun
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Lymphocytes ◽  
Pulmonary Disease ◽  
Cardiac Remodeling ◽  
Heart Tissue ◽  
Autoimmune Response ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Cell Immunity ◽  
Tissue Antigens

Abstract Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+, CD8+ subsets of T-lymphocytes autoimmune lymphocytotoxic and granulocytotoxic antibodies, circulating immune complexes, bacterial sensibilization and hypersensitivity by the delayed type to the host heart tissue antigens. It turned out that progression of COPD is characterized by the decrease of cell immunity with formation of bacterial sensibilization and autosensibilization to the heart tissue antigens, strongly associated with cardiac remodeling. Thus, the presence of autoimmune response significantly contributes to the changes of heart geometry in patients with COPD.

scholarly journals Informativeness of cytokine profile in predicting complications in patients with myocardial infarction on background of chronic obstructive pulmonary disease

2019 ◽  
Vol 3 (22) ◽  
pp. 33-36
Author(s):  
A. V. Naumov ◽  
L. V. Saroyants ◽  
T. V. Prokofyeva ◽  
O. S. Polunina ◽  
E. A. Polunina
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Left Ventricular ◽  
Cytokine Profile ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Main Indicator ◽  
Complications Of Myocardial Infarction

Objective. To determine the information content of the cytokine profile (IL-1β, IL-2 and IL-6) in predicting complications in patients with myocardial infarction (MI) against the background of chronic obstructive pulmonary disease (COPD).Materials and methods. In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (MI + COPD) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.Results. When assessing the cytokine profile in patients with MI and MI against the background of COPD, the most pronounced differences between groups of patients were observed in the levels of IL-6. Analyzing the association of the level of IL-6 with the presence of early complications of MI, it was found that the level of IL-6 in patients with complicated MI was significantly higher than in patients with uncomplicated course. The highest level of IL-6 was recorded in the subgroup of patients with complicated myocardial infarction during COPD. Studying the levels of IL-6 depending on the type of complications of myocardial infarction showed that the highest values of IL-6 were recorded in the group of comorbid patients with cardiogenic shock and pulmonary edema.Conclusion. When determining the cytokine status in patients with myocardial infarction on the background of COPD, the level of IL-6 should be considered as the main indicator. This cytokine can be considered a marker of left ventricular that developed in the acute period in patients with myocardial infarction on the background of COPD.

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