Lower ability to oxidize lipids in adult patients with growth hormone (GH) deficiency: reversal under GH treatment

2006 ◽  
Vol 65 (4) ◽  
pp. 423-428 ◽  
Author(s):  
F. Brandou ◽  
I. Aloulou ◽  
A. Razimbaud ◽  
C. Fédou ◽  
J. Mercier ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Adult Patients ◽  
Gh Treatment ◽  
Lower Ability

scholarly journals Impact of Growth Hormone (GH) Deficiency and GH Replacement upon Thymus Function in Adult Patients

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5668 ◽  
Author(s):  
Gabriel Morrhaye ◽  
Hamid Kermani ◽  
Jean-Jacques Legros ◽  
Frederic Baron ◽  
Yves Beguin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Adult Patients ◽  
Gh Replacement

scholarly journals Growth Hormone (GH) Treatment Up-Regulates GH Receptor mRNA Levels in Adipocytes from Patients with GH Deficiency and Prader-Willi Syndrome

1995 ◽  
Vol 38 (3) ◽  
pp. 418-421 ◽  
Author(s):  
Ashraf Kamel ◽  
Véronique Margery ◽  
Gunnar Norstedt ◽  
Marja Thorén ◽  
Anne-Christine Lindgren ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Prader Willi Syndrome ◽  
Mrna Levels ◽  
Gh Treatment ◽  
Receptor Mrna ◽  
Gh Receptor

scholarly journals Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency

1999 ◽  
Vol 46 (Suppl) ◽  
pp. S35-S38 ◽  
Author(s):  
RYUICHI KUROMARU ◽  
HITOSHI KOHNO ◽  
NAMI UEYAMA ◽  
HASSAN MOHAMED SALAMA HASSAN ◽  
SUNAO HONDA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Gh Deficiency ◽  
Term Effect ◽  
Gh Treatment ◽  
Long Term Effect

Growth Hormone Therapy in Children with Kabuki Syndrome: 1-year Treatment Results

2017 ◽  
Vol 88 (3-4) ◽  
pp. 258-264 ◽  
Author(s):  
Dina A. Schott ◽  
Willem J.M. Gerver ◽  
Constance T.R.M. Stumpel
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Standard Deviation Score ◽  
Height Velocity ◽  
Kabuki Syndrome ◽  
Body Proportions ◽  
Leg Length ◽  
Gh Treatment ◽  
Igf I ◽  
Rhgh Treatment

Background/Aims: Kabuki syndrome (KS) is a rare genetic malformation syndrome, resulting in characteristic features such as short stature. We investigate whether growth hormone (GH) treatment increases linear height and influences body proportions in KS children. Methods: In this prospective study, 18 genetically confirmed prepubertal KS children (9 females and 9 males) aged from 3.8 to 10.1 years (mean 6.8 ± 2.1 years) were treated with recombinant human GH (rhGH) for 1 year. Calculations for height, height velocity, BMI, sitting height, and subischial leg length were made. Bone age, insulin-like growth factor (IGF-I), and IGF binding protein 3 (IGFBP-3) were also measured. Results: This study showed an increase in height standard deviation score (SDS) for the whole group from –2.40 to –1.69 (p < 0.05) after 1 year of rhGH treatment. The change in height SDS within 1 year was >0.7 SDS for 10 subjects and >0.5 SDS for 3 subjects. The mean IGF-I SDS at the start of the study was –0.70 (±1.07), which increased after 12 months to 1.41 (±0.91) (p < 0.05). KS children who received rhGH at a younger age displayed significantly greater increases in height than those who started when they were older. The same was true for both gene mutation KMT2D versus KDM6A and for GH deficiency versus non-GH deficiency KS children (p < 0.05). Throughout the course of rhGH treatment, the subjects’ body proportions remained normal. Conclusions: All participants experienced catch-up growth during the year of rhGH treatment, but without an influence on body proportions.

Sign in / Sign up

Export Citation Format

Share Document