Gender Differences in the Effects of Long Term Growth Hormone (GH) Treatment on Bone in Adults with GH Deficiency

1999 ◽  
Vol 84 (6) ◽  
pp. 2002-2007 ◽  
Author(s):  
A. G. Johansson
1999 ◽  
Vol 46 (Suppl) ◽  
pp. S35-S38 ◽  
Author(s):  
RYUICHI KUROMARU ◽  
HITOSHI KOHNO ◽  
NAMI UEYAMA ◽  
HASSAN MOHAMED SALAMA HASSAN ◽  
SUNAO HONDA ◽  
...  

2017 ◽  
Author(s):  
Jens Otto Jorgensen ◽  
Vera Popovic-Brkic ◽  
Effie Pournara ◽  
Birgitte Pedersen ◽  
Anita Chudecka ◽  
...  

1999 ◽  
Vol 84 (6) ◽  
pp. 2002-2007
Author(s):  
Anna G. Johansson ◽  
Britt Edén Engström ◽  
Sverker Ljunghall ◽  
F. Anders Karlsson ◽  
Pia Burman

Author(s):  
Lucia Schena ◽  
Cristina Meazza ◽  
Sara Pagani ◽  
Valeria Paganelli ◽  
Elena Bozzola ◽  
...  

AbstractBackground:In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients.Methods:We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels. The patients were treated with recombinant human GH (rhGH) and followed until they reach adult height.Results:During GH treatment, the two groups grew in parallel, reaching the same final height-standard deviation score (SDS) and the same height gain. On the contrary, we found significantly lower IGF-I serum concentrations in non-GHD patients than in GHD ones, at the end of therapy (p=0.0055).Conclusions:In our study, the response to GH treatment in short non-GHD patients proved to be similar to that in GHD ones. However, a careful selection of short non-GHD children to be treated with GH would better justify the cost of long-term GH therapy.


2006 ◽  
Vol 65 (4) ◽  
pp. 423-428 ◽  
Author(s):  
F. Brandou ◽  
I. Aloulou ◽  
A. Razimbaud ◽  
C. Fédou ◽  
J. Mercier ◽  
...  

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