Over expression of a Cytochrome P450 (CYP6P9) in a Major African Malaria Vector, Anopheles Funestus, Resistant to Pyrethroids

2008 ◽  
Vol 17 (1) ◽  
pp. 19-25 ◽  
Author(s):  
D. A. Amenya ◽  
R. Naguran ◽  
T.-C. M. Lo ◽  
H. Ranson ◽  
B. L. Spillings ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
Over Expression

scholarly journals Correction: Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus

Heredity ◽  
2020 ◽  
Vol 125 (5) ◽  
pp. 371-371 ◽  
Author(s):  
Magellan Tchouakui ◽  
Jacob Riveron Miranda ◽  
Leon M. J. Mugenzi ◽  
Doumani Djonabaye ◽  
Murielle J. Wondji ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
Fitness Cost ◽  
Metabolic Resistance

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa

2021 ◽  
Vol 138 ◽  
pp. 103647 ◽  
Author(s):  
Amelie N.R. Wamba ◽  
Sulaiman S. Ibrahim ◽  
Michael O. Kusimo ◽  
Abdullahi Muhammad ◽  
Leon M.J. Mugenzi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Central Africa ◽  
Major Malaria Vector

scholarly journals Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique

2019 ◽  
Vol 220 (3) ◽  
pp. 467-475 ◽  
Author(s):  
Jacob M Riveron ◽  
Silvie Huijben ◽  
Williams Tchapga ◽  
Magellan Tchouakui ◽  
Murielle J Wondji ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Resistance Mechanisms ◽  
Piperonyl Butoxide ◽  
Insecticide Treated Nets ◽  
Molecular Analyses ◽  
Cytochrome P450 Genes ◽  
High Degree ◽  
Long Lasting Insecticidal Nets

Abstract Background Insecticide resistance poses a serious threat to insecticide-based interventions in Africa. There is a fear that resistance escalation could jeopardize malaria control efforts. Monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict consequences of resistance. Methods The resistance levels of an Anopheles funestus population from Palmeira, southern Mozambique, were characterized and their impact on the efficacy of various insecticide-treated nets established. Results A dramatic loss of efficacy of all long-lasting insecticidal nets (LLINs), including piperonyl butoxide (PBO)–based nets (Olyset Plus), was observed. This An. funestus population consistently (2016, 2017, and 2018) exhibited a high degree of pyrethroid resistance. Molecular analyses revealed that this resistance escalation was associated with a massive overexpression of the duplicated cytochrome P450 genes CYP6P9a and CYP6P9b, and also the fixation of the resistance CYP6P9a_R allele in this population in 2016 (100%) in contrast to 2002 (5%). However, the low recovery of susceptibility after PBO synergist assay suggests that other resistance mechanisms could be involved. Conclusions The loss of efficacy of pyrethroid-based LLINs with and without PBO is a concern for the effectiveness of insecticide-based interventions, and action should be taken to prevent the spread of such super-resistance.

scholarly journals Evidence of a multiple insecticide resistance in the malaria vector Anopheles funestus in South West Nigeria

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Rousseau J. Djouaka ◽  
Seun M. Atoyebi ◽  
Genevieve M. Tchigossou ◽  
Jacob M. Riveron ◽  
Helen Irving ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
South West

scholarly journals Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae

2002 ◽  
Vol 11 (5) ◽  
pp. 409-418 ◽  
Author(s):  
H. Ranson ◽  
D. Nikou ◽  
M. Hutchinson ◽  
X. Wang ◽  
C. W. Roth ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Anopheles Gambiae ◽  
Molecular Analysis ◽  
Malaria Vector ◽  
Cytochrome P450 Genes

scholarly journals A chromosome-scale assembly of the major African malaria vector Anopheles funestus

GigaScience ◽  
2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Jay Ghurye ◽  
Sergey Koren ◽  
Scott T Small ◽  
Seth Redmond ◽  
Paul Howell ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus
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